Impact of a single human leucocyte antigen (HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLA Working Group of the Japan Society for Blood and Marrow

2013 ◽  
Vol 161 (4) ◽  
pp. 566-577 ◽  
Author(s):  
Yoshinobu Kanda ◽  
Junya Kanda ◽  
Yoshiko Atsuta ◽  
Yoshinobu Maeda ◽  
Tatsuo Ichinohe ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Retrospective Analysis ◽  
Marrow Transplantation ◽  
Working Group ◽  
Human Leucocyte Antigen ◽  
Japan Society ◽  
Unrelated Bone Marrow Transplantation ◽  
Time Periods

Mycobacterium avium complex-associated peritonitis with CAPD after unrelated bone marrow transplantation

2014 ◽  
Vol 56 (6) ◽  
pp. e96-e98 ◽  
Author(s):  
Emiko Miyashita ◽  
Hisao Yoshida ◽  
Daisuke Mori ◽  
Natsuki Nakagawa ◽  
Takako Miyamura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Mycobacterium Avium ◽  
Marrow Transplantation ◽  
Mycobacterium Avium Complex ◽  
Unrelated Bone Marrow Transplantation

Influence of HLA 1–3-locus mismatch and antithymocyte globulin administration in unrelated bone marrow transplantation

2020 ◽  
Vol 99 (5) ◽  
pp. 1099-1110
Author(s):  
Koji Kawamura ◽  
Junya Kanda ◽  
Kazuteru Ohashi ◽  
Takahiro Fukuda ◽  
Koji Iwato ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Antithymocyte Globulin ◽  
Unrelated Bone Marrow Transplantation

Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood.

1997 ◽  
Vol 15 (2) ◽  
pp. 566-573 ◽  
Author(s):  
F Locatelli ◽  
C Niemeyer ◽  
E Angelucci ◽  
C Bender-Götze ◽  
S Burdach ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Myelodysplastic Syndrome ◽  
Marrow Transplantation ◽  
Working Group ◽  
Allogeneic Bone Marrow Transplantation ◽  
Chronic Myelomonocytic Leukemia ◽  
Allogeneic Bone ◽  
European Working ◽  
Myelomonocytic Leukemia

PURPOSE To evaluate the role of allogeneic bone marrow transplantation (BMT) in children with chronic myelomonocytic leukemia (CMML). PATIENTS AND METHODS Forty-three children with CMML given BMT and reported to the European Working Group on Myelodysplastic Syndrome in Childhood (EWOG-MDS) data base were evaluated. In 25 cases, the donor was a human leukocyte antigen (HLA)-identical or a one-antigen-disparate relative, in four cases a mismatched family donor, and in 14 a matched unrelated donor (MUD). Conditioning regimens consisted of total-body irradiation (TBI) and chemotherapy in 22 patients, whereas busulfan (Bu) with other cytotoxic drugs was used in the remaining patients. RESULTS Six of 43 patients (14%), five of whom received transplants from alternative donors, failed to engraft. There was a significant difference in the incidences of chronic graft-versus-host disease (GVHD) between children transplanted from compatible/one-antigen-mismatched relatives and from alternative donors (23% and 87%, respectively; P < .005). Probabilities of transplant-related mortality for children given BMT from HLA-identical/one-antigen-disparate relatives or from MUD/ mismatched relatives were 9% and 46%, respectively. The probability of relapse for the entire group was 58%, whereas the 5-year event-free survival (EFS) rate was 31%. The EFS rate for children given BMT from an HLA-identical sibling or one-antigen-disparate relative was 38%. In this latter group, patients who received Bu had a better EFS compared with those given TBI (62% v 11%, P < .01). CONCLUSION Children with CMML and an HLA-compatible relative should be transplanted as early as possible. Improvement of donor selection, GVHD prophylaxis, and supportive care are needed to ameliorate results of BMT from alternative donors.

Influence of donors/recipients HLA-C disparity in 110 unrelated bone marrow transplantation

1996 ◽  
Vol 47 (1-2) ◽  
pp. 80
Author(s):  
Z. Tatari ◽  
H. Espérou ◽  
C. Chastang ◽  
C. Fortier ◽  
J.C. Bensa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Unrelated Bone Marrow Transplantation

High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation

1996 ◽  
Vol 47 (1-2) ◽  
pp. 82
Author(s):  
Jeannet Michel ◽  
Speiser Daniel ◽  
Rufer Nathalie ◽  
Grundschober Christophe ◽  
Gratwohl Alois ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
High Resolution ◽  
Marrow Transplantation ◽  
Hla Matching ◽  
Unrelated Bone Marrow Transplantation
Sign in / Sign up

Export Citation Format

Share Document