scholarly journals Validation of an Oral Disease Severity Score for use in oral lichen planus

2022 ◽  
Author(s):  
Martyn Ormond ◽  
Helen McParland ◽  
Priya Thakrar ◽  
Ana Donaldson ◽  
Manoharan Andiappan ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lichen Planus ◽  
Severity Score ◽  
Oral Lichen Planus ◽  
Oral Disease ◽  
Disease Severity Score ◽  
Oral Lichen

Criteria for assessing severity of oral lichen planus

MedAlliance ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 73-81
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Severity Score ◽  
Oral Lichen Planus ◽  
Unknown Etiology ◽  
Altered Level ◽  
Doppler Flowmetry ◽  
Serum Free ◽  
Control Subjects ◽  
Oral Lichen

Introduction. Oral lichen planus (OLP) is an autoim- mune disease of unknown etiology, manifested in vari- ous clinical forms. A correlation between intensity of OLP local manifestations and severity of general disturbances predisposing to altered oral mucosa have been poorly investigated. The aim of our study was to identify criteria for assessing OLP severity score. Methods. OLP patients and control subjects (not OLP) matched by hepatobiliary disease and type IIa dyslipidemia were examined. Samples collected during the study were as- sessed by way clinical examination, gas chromatographic analysis of serum free fatty acids (FFA), oral fluid, serum and fecal microbial marker analysis by gas chromatogra- phy/mass spectrometry, laser Doppler flowmetry of the oral mucosa, immunohistochemistry staining with an- ti-CD68 monoclonal antibody specific to apolipoprotein B-100-bearing macrophages. Results. It was found that OLP patients significantly differed from control subjects in the three FFA levels (lauric acid, eicosopentaenoic/ lauric and eicosopentaenoic/linoleic ratios), displayed four pathologic factors matching the altered level of mi- crobial markers. In addition, OLP patients were found to differ in oral mucosa blood filling both inside and outside lesions paralleled with oxidative changes immediately in oral mucosa highlighted as elevated amount of apo- lipoprotein B-100-bearing CD68-positive macrophages. Conclusion. OLP severity score is an integrate parameter which reflects oxidative changes and alterations in oral mucosa microhemocirculation primarily in serum free fat- ty acid composition, altered oral and gut microbiota as well as intensity score of clinical picture.

IL-25 promotes Th2-type reactions and correlates with disease severity in the pathogenesis of oral lichen planus

2019 ◽  
Vol 98 ◽  
pp. 115-121
Author(s):  
Hui Wang ◽  
Yuchen Jiang ◽  
Hongning Wang ◽  
Zhenhua Luo ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Disease Severity ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

Is the Oral Disease Severity Score going to be useful for dermatologists when assessing pemphigus? Reply from the authors

2018 ◽  
Vol 179 (4) ◽  
pp. 1012-1013
Author(s):  
J.F. Setterfield ◽  
M. Ormond ◽  
A.N.A. Donaldson ◽  
S.J. Challacombe
Keyword(s):  
Disease Severity ◽  
Severity Score ◽  
Oral Disease ◽  
Disease Severity Score

A scoring system for mucosal disease severity with special reference to oral lichen planus

2007 ◽  
Vol 157 (4) ◽  
pp. 765-770 ◽  
Author(s):  
M. Escudier ◽  
N. Ahmed ◽  
P. Shirlaw ◽  
J. Setterfield ◽  
A. Tappuni ◽  
...  
Keyword(s):  
Special Reference ◽  
Disease Severity ◽  
Lichen Planus ◽  
Scoring System ◽  
Oral Lichen Planus ◽  
Mucosal Disease ◽  
Oral Lichen

scholarly journals Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid

2019 ◽  
Vol 183 (1) ◽  
pp. 78-85 ◽  
Author(s):  
M. Ormond ◽  
H. McParland ◽  
P. Thakrar ◽  
A.N.A. Donaldson ◽  
M. Andiappan ◽  
...  
Keyword(s):  
Disease Severity ◽  
Mucous Membrane ◽  
Severity Score ◽  
Oral Disease ◽  
Mucous Membrane Pemphigoid ◽  
Disease Severity Score ◽  
Oral Mucous Membrane

scholarly journals The Assessment of Angiogenesis by Microvessel Density in Patients With Atrophic/Erosive or Reticular Oral Lichen Planus

2021 ◽  
Author(s):  
Maryam Mardani ◽  
Azadeh Andisheh-Tadbir ◽  
Mahya Haghparast
Keyword(s):  
Lichen Planus ◽  
Microvessel Density ◽  
Oral Lichen Planus ◽  
Precancerous Lesions ◽  
Oral Disease ◽  
Staining Procedure ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
Oral Lichen

The role of angiogenesis in the development of chronic inflammatory diseases, including oral lichen planus (OLP), is of great concern. The most representative method for the assessment of angiogenesis is the semi-quantification of microvessel density (MVD) using specific markers such as CD105. We aimed to assess the MVD in patients with OLP and find its clinical significance to differentiate the atrophic/erosive forms from reticular ones. This cross-sectional study was conducted on 82 patients with clinically and histopathologically proven cases of OLP, including reticular (n=52) or atrophic/erosive (n=30) lesions. The control group comprised 82 age- and sex-matched subjects without any oral disease. To assess the MVD using CD105, tissue blocks were sliced, and the immunoexpression of CD105 was measured by the standard immunohistochemical staining procedure. The mean value of MVD in OLP patients was significantly higher than that in the controls (14.61±12.48 vs. 8.67±1.76, P<0.0001). Furthermore, there was a significant difference in the mean MVD value between reticular and atrophic/erosive lesions (8.19±7.13 vs. 25.73±12.06, P=0.001). However, no significant difference was observed between the reticular lesions and normal tissues (P=0.58). An increased level of CD105 in OLP patients can improve our knowledge about the causes and mechanisms of the disease. The CD105-MVD assessment might be a useful method for semiquantitative measurement of angiogenesis in OLP patients as well as differentiating its clinical forms; therefore, it can open new vistas for formulating strategies based on antiangiogenic treatments for the management of OLP and other precancerous lesions.

scholarly journals Case Report: Treatment of Oral Lichen Planus With a Focus on Psychological Methods

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuli Song ◽  
Xueqi Wu ◽  
Chunye Wang ◽  
Shuguang Sun ◽  
Xiangyang Zhang
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Acute Stress ◽  
Oral Disease ◽  
Emotional Instability ◽  
Psychological Counseling ◽  
Mental Problems ◽  
Somatic Diseases ◽  
Oral Lichen

Oral lichen planus (OLP) is one of the most common chronic diseases; however, its etiology remains unknown. More and more studies have revealed that emotional instability is one of the risk factors for the onset and expansion of OLP, especially in patients suffering from depression, anxiety disorder, and acute stress. In this case report, we had a 32-year-old female OLP patient who had no obvious response to conventional OLP drugs. Then we switched to a combination of psychotropic drugs and psychotherapies. By regulating mood through drugs and psychological counseling, the patient's oral disease was alleviated. Our case shows that clinicians should consider the mental problems of OLP patients. It also emphasizes the importance of medications and psychological counseling in the treatment of somatic diseases.

scholarly journals Helicobacter Pylori Infection Increases the Incidence of Erosive Oral Lichen Planus and Alters the Oral Microbiome Composition

2021 ◽  
Author(s):  
Yangheng Zhang ◽  
Shutong Li ◽  
Jingyuan Li ◽  
Ya Li ◽  
Huanjie Li ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Oral Diseases ◽  
Microbiome Composition ◽  
Carbon 14 ◽  
Increased Risk ◽  
H Pylori ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP), a common clinical oral disease, is associated with an increased risk for malignant transformation. The mechanism underlying the pathogenesis of OLP is unknown. Oral dysbacteriosis is reported to be one of the etiological factors for OLP. Although H. pylori infection is associated with various oral diseases, the correlation between H. pylori infection and OLP is unclear. This study aimed to investigate the effect of H. pylori infection on OLP pathogenesis and oral microbiome composition in the Chinese population, which has a high incidence of H. pylori infection.Result In this study, the saliva samples of 30 patients with OLP (OLP group) and 21 negative controls (NC group) were collected. H. pylori infection was detected using the carbon-14 urea breath test. The saliva samples were divided into the following four groups based on the H. pylori infection status: H. pylori-positive OLP (OLP+), H. pylori-positive NC (NC+), H. pylori-negative OLP (OLP−), and H. pylori-negative NC (NC−) groups. The oral microbiome composition was significantly different between the OLP and NC groups and between the OLP− and OLP+ groups. Compared with those in the OLP− group, the incidence of erosive OLP and the salivary levels of cytokines were higher in the OLP+ group. In contrast, the oral microbiome composition and cytokine levels were not significantly different between the NC− and NC+ groups.Conclusions This is the first report demonstrated that H. pylori infection is significantly correlated with the pathogenesis of erosive OLP. The alleviation of H. pylori infection may decrease the incidence of erosive OLP.

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