scholarly journals Transcriptomic changes during stage progression of mycosis fungoides: from translational analyses to their potential clinical implications

2021 ◽  
Author(s):  
G. Dobos ◽  
C. Assaf
Keyword(s):  
Mycosis Fungoides ◽  
Clinical Implications ◽  
Stage Progression ◽  
Transcriptomic Changes

scholarly journals Transcriptomic Changes During Stage Progression of Mycosis Fungoides

2021 ◽  
Author(s):  
M.Z.X. Xiao ◽  
D. Hennessey ◽  
A. Iyer ◽  
S. O’Keefe ◽  
F. Zhang ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Stage Progression ◽  
Transcriptomic Changes

scholarly journals Transcriptomic Changes During Stage Progression of Mycosis Fungoides

2021 ◽  
Author(s):  
Maggie Xiao ◽  
Dylan Hennessey ◽  
Aishwarya Iyer ◽  
Sandra O'Keefe ◽  
Frederick Zhang ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Late Stage ◽  
Early Stage ◽  
Skin Lesions ◽  
Advanced Stage ◽  
Stage Progression ◽  
Whole Exome ◽  
Stage Disease ◽  
Skin Biopsies ◽  
Transcriptomic Changes

Background: Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma, which in the early patch/plaque stages runs an indolent course. However, ~25% of MF patients develop skin tumors, a hallmark of progression to the advanced stage and associated with high mortality. The mechanisms involved in stage progression are poorly elucidated. Methods: We performed whole-transcriptome and whole-exome sequencing of malignant MF cells from skin biopsies obtained by laser-capture microdissection. We compared three types of MF lesions: early-stage plaques (ESP, n=12), and plaques and tumors from patients in late-stage disease (late-stage plaques, LSP, n=10, and tumors, TMR, n=15). Gene Ontology (GO) and KEGG analysis were used to determine pathway changes specific for different lesions which we linked to the recurrent somatic mutations overrepresented in MF tumors. Results: The key upregulated pathways during stage progression were those related to cell proliferation and survival (MEK/ERK, Akt-mTOR), Th2/Th9 signaling (IL4, STAT3, STAT5, STAT6), meiomitosis (CT45A1, CT45A3, STAG3, GTSF1, and REC8) and DNA repair (PARP1, MYCN, OGG1). Principal coordinate clustering of the transcriptome revealed extensive gene expression differences between early (ESP) and advanced-stage lesions (LSP and TMR). LSP and TMR showed remarkable similarities at the level of the transcriptome, which we interpreted as evidence of cell percolation between lesions via hematogenous self-seeding. Conclusion: Stage progression in MF is associated with Th2/Th9 polarization of malignant cells, activation of proliferation, survival, as well as increased genomic instability. Global transcriptomic changes in multiple lesions are probably caused by hematogenous cell percolation between discrete skin lesions.

Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides-Cutaneous T-cell lymphoma: Clinical implications

2013 ◽  
Vol 134 (9) ◽  
pp. 2136-2145 ◽  
Author(s):  
M. Alcántara-Hernández ◽  
C. Torres-Zárate ◽  
G. Pérez-Montesinos ◽  
F. Jurado-Santacruz ◽  
M.A. Domínguez-Gómez ◽  
...  
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
Hypoxia Inducible Factor ◽  
T Cell Lymphoma ◽  
Clinical Implications ◽  
Cutaneous T Cell Lymphoma ◽  
Hypoxia Inducible Factor 1

Clinical Implications of Transcriptomic Changes After Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

2019 ◽  
Vol 26 (10) ◽  
pp. 3185-3193
Author(s):  
Javier I. J. Orozco ◽  
Janie G. Grumley ◽  
Chikako Matsuba ◽  
Ayla O. Manughian-Peter ◽  
Shu-Ching Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Clinical Implications ◽  
Transcriptomic Changes

scholarly journals The histological prevalence and clinical implications of folliculotropism and syringotropism in mycosis fungoides

2019 ◽  
Vol 8 (1) ◽  
pp. 6-6
Author(s):  
Claudia Hossain ◽  
Tara Jennings ◽  
Robert Duffy ◽  
Kelly Knoblauch ◽  
Ashley Gochoco ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Clinical Implications

scholarly journals Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1409
Author(s):  
Melika Motamedi ◽  
Maggie Z. X. Xiao ◽  
Aishwarya Iyer ◽  
Robert Gniadecki
Keyword(s):  
Systematic Review ◽  
Mycosis Fungoides ◽  
Chromosomal Instability ◽  
Cell Lymphoma ◽  
Immune Checkpoints ◽  
Cutaneous T Cell Lymphoma ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Transcriptomic Changes ◽  
Late Stages

Mycosis fungoides (MF) is the most prevalent type of skin lymphoma. In its early stages, it has a favorable prognosis. However, in its late stages, it is associated with an increased risk of mortality. This systematic review aimed to identify the transcriptomic changes involved in MF pathogenesis and progression. A literature search was conducted using the database PubMed, followed by the extraction of 2245 genes which were further filtered to 150 recurrent genes that appeared in two or more publications. Categorization of these genes identified activated pathways involved in pathways such as cell cycle and proliferation, chromosomal instability, and DNA repair. We identified 15 genes implicated in MF progression, which were involved in cell proliferation, immune checkpoints, resistance to apoptosis, and immune response. In highlighting the discrepancies in the way MF transcriptomic data is obtained, further research can focus on not only unifying their approach but also focus on the 150 pertinent genes identified in this review.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Perceptions of Stuttering of Different Age Groups

2019 ◽  
Vol 4 (6) ◽  
pp. 1311-1315
Author(s):  
Sergey M. Kondrashov ◽  
John A. Tetnowski
Keyword(s):  
Age Groups ◽  
School Age Children ◽  
Clinical Implications ◽  
School Age ◽  
Fourth Edition ◽  
Self Perception ◽  
Behavioral Measures ◽  
Self Rating ◽  
Comparison Results ◽  
Subject Pool

Purpose The purpose of this study was to assess the perceptions of stuttering of school-age children who stutter and those of adults who stutter through the use of the same tools that could be commonly used by clinicians. Method Twenty-three participants across various ages and stuttering severity were administered both the Stuttering Severity Instrument–Fourth Edition (SSI-4; Riley, 2009 ) and the Wright & Ayre Stuttering Self-Rating Profile ( Wright & Ayre, 2000 ). Comparisons were made between severity of behavioral measures of stuttering made by the SSI-4 and by age (child/adult). Results Significant differences were obtained for the age comparison but not for the severity comparison. Results are explained in terms of the correlation between severity equivalents of the SSI-4 and the Wright & Ayre Stuttering Self-Rating Profile scores, with clinical implications justifying multi-aspect assessment. Conclusions Clinical implications indicate that self-perception and impact of stuttering must not be assumed and should be evaluated for individual participants. Research implications include further study with a larger subject pool and various levels of stuttering severity.

Treatment Considerations for Adolescents Who Exhibit Cognitive/Communication Problems: A Neuroscience Perspective

2020 ◽  
Vol 5 (6) ◽  
pp. 1767-1775
Author(s):  
Martha S. Burns
Keyword(s):  
Social Communication ◽  
Transition Period ◽  
Clinical Intervention ◽  
Review Article ◽  
Sensitive Period ◽  
Clinical Implications ◽  
Evidence Based ◽  
Communication Problems ◽  
Treatment Considerations ◽  
Behavioral Growth

Purpose Adolescence is a period of substantial neurophysiological and behavioral growth, representing a second sensitive period of brain development. It is a psychological and social transition period between childhood and adulthood with many beneficial changes occurring, especially with respect to potential responsiveness to clinical intervention. However, adolescent behavioral complexities introduce clinical challenges as well. The purpose of this review article is to review the current neuroimaging research on neurophysiological changes observed during adolescence and the cognitive and social behavioral counterparts, with specific attention to the clinical implications. The review article will then summarize currently available intervention tools that can be utilized by speech-language pathologists working with this population. It will conclude with available evidence-based social-communication approaches that may be applicable as well as available evidence-based supplemental technological cognitive interventions that may be useful in working with adolescents who exhibit language and communication issues. Conclusion As a transition period between childhood and adulthood, adolescence represents a second sensitive period during which there is opportunity for clinically derived beneficial cognitive and communication growth.

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