The potential skin lightening candidate, senolytic drug ABT263, for photoageing pigmentation

2021 ◽  
Author(s):  
J.H. Park ◽  
J.E. Yoon ◽  
Y.H. Kim ◽  
Y. Kim ◽  
T.J. Park ◽  
...  
Keyword(s):  
Skin Lightening

scholarly journals Lightening Effect of Skin Lightening Cream Containing Piper betle L. Extract in Human Volunteers

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 32
Author(s):  
Sharifah Shakirah Syed Omar ◽  
Hazrina Hadi ◽  
Nadzira Mohd Hanif ◽  
Hawa Mas Azmar Ahmad ◽  
Shiow-Fern Ng
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Human Subjects ◽  
Skin Barrier ◽  
Skin Tone ◽  
In Vivo Studies ◽  
Piper Betle ◽  
Melanin Content ◽  
Skin Lightening

Hyperpigmentation affects people globally with negative psychological impacts. Piper betle L. leaf (PBL) extract has many benefits including skin lightening which may reduce hyperpigmentation. The objective of this study was to develop an effective skin-lightening cream containing PBL with ideal characteristics. A formulation of base cream and PBL cream was prepared and characterized by centrifugation, particle size and zeta potential analysis, rheological profile studies and physical properties’ observation. In vivo studies on 30 human subjects tested the effects of base and PBL cream on skin-lightening, hydration, trans-epidermal water loss (TEWL) and elasticity through weekly tests 4 weeks in duration. Base and PBL creams had a non-Newtonian property with acceptable color, odor, texture, zeta potential, particle size and showed no phase separation. The in vivo study indicated a significant reduction in melanin content and an improvement in skin tone for PBL cream but not in base cream. TEWL and elasticity also showed significant reduction for both formulations, indicating a healthier skin barrier and supple skin with consistent use, although hydration fluctuated with no significant changes. The developed PBL cream showed significant results in the reduction in melanin content and improving skin tone, which shows the formulation can confer skin-lightening effect.

scholarly journals Darker shades of “fairness” in India: Male attractiveness and colorism in commercials

2020 ◽  
Vol 6 (1) ◽  
pp. 225-248
Author(s):  
Sayantan Mukherjee
Keyword(s):  
Critical Discourse Analysis ◽  
Skin Tone ◽  
Indian Society ◽  
Primary Data ◽  
Television Commercials ◽  
Multimodal Analysis ◽  
Light Skin ◽  
Indian Men ◽  
Skin Lightening

AbstractThe skin-lightening products for men in India and their mode of advertising have been shaping the concept of attractiveness for Indian men by portraying lighter skin tone as the most fundamental quality of being attractive, always desirable, and successful. Although women’s skin-lightening products in India have received attention by a few scholars lately, men’s products are still underresearched. Hence, this study aims to investigate the issue of colorism augmented by television commercials for men’s “fairness” (light skin tone) products in India. The primary data for this study are six Hindi television commercials for men’s skin-lightening products which were broadcast from 2005 to 2015 and were available on YouTube during data collection. The commercials are by one popular brand, Emami Fair and Handsome. The target commercials are significant for their categorical distinction in directness as well as for their nature of storytelling that helps facilitate the discourse of colorism itself. The methodology is a combination of multimodal analysis, critical discourse analysis, and advertisement analysis. The overall goal of this study is to bring visibility to this subtle and multilayered problem of colorism in Indian society which is being reinforced by the skin-lightening products for men.

Soluble Pearl Extract provides effective skin lightening by antagonizing endothelin

2020 ◽  
Author(s):  
Jing Wang ◽  
Zhixiong Chen ◽  
Yaojia Lu ◽  
Lihua Zhang ◽  
Jiahuan Mo ◽  
...  
Keyword(s):  
Skin Lightening

Spectrometric analysis of mercury content in 549 skin-lightening products: Is mercury toxicity a hidden global health hazard?

2014 ◽  
Vol 70 (2) ◽  
pp. 281-287.e3 ◽  
Author(s):  
Carsten R. Hamann ◽  
Waranya Boonchai ◽  
Liping Wen ◽  
Emi Nishijima Sakanashi ◽  
Chia-Yu Chu ◽  
...  
Keyword(s):  
Global Health ◽  
Health Hazard ◽  
Mercury Content ◽  
Spectrometric Analysis ◽  
Mercury Toxicity ◽  
Skin Lightening

Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics

2010 ◽  
Vol 29 (6_suppl) ◽  
pp. 244S-273S ◽  
Author(s):  
Christina L. Burnett ◽  
Wilma F. Bergfeld ◽  
Donald V. Belsito ◽  
Ronald A. Hill ◽  
Curtis D. Klaassen ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Safety Assessment ◽  
Expert Panel ◽  
Kojic Acid ◽  
Tumor Promotion ◽  
Final Report ◽  
Cosmetic Products ◽  
Pig Skin ◽  
Animal Data ◽  
Skin Lightening

Kojic acid functions as an antioxidant in cosmetic products. Kojic acid was not a toxicant in acute, chronic, reproductive, and genotoxicity studies. While some animal data suggested tumor promotion and weak carcinogenicity, kojic acid is slowly absorbed into the circulation from human skin and likely would not reach the threshold at which these effects were seen. The available human sensitization data supported the safety of kojic acid at a use concentration of 2% in leave-on cosmetics. Kojic acid depigmented black guinea pig skin at a concentration of 4%, but this effect was not seen at 1%. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the 2 end points of concern, dermal sensitization and skin lightening, would not be seen at use concentrations below 1%; therefore, this ingredient is safe for use in cosmetic products up to that level.

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