scholarly journals Clinical response of rituximab and improvement of quality of life in patients with bullous pemphigoid and mucous membrane pemphigoid

2021 ◽  
Author(s):  
H. Rashid ◽  
J.M. Meijer ◽  
M.C. Bolling ◽  
B. Horvath
Keyword(s):  
Quality Of Life ◽  
Clinical Response ◽  
Bullous Pemphigoid ◽  
Mucous Membrane ◽  
Mucous Membrane Pemphigoid

Stressful Life Events as a Trigger for Autoimmune Disease? A Case Report on Mucous Membrane Pemphigoid

Dental Update ◽  
2021 ◽  
Vol 48 (5) ◽  
pp. 379-382
Author(s):  
Robert Devine ◽  
Melanie Simms
Keyword(s):  
Mucous Membrane ◽  
Patient Outcomes ◽  
Stressful Life Events ◽  
Treatment Options ◽  
Rare Condition ◽  
Corticosteroid Treatment ◽  
Diagnostic Tools ◽  
Mucous Membrane Pemphigoid ◽  
Acute Presentation

This case discusses the acute presentation of a patient with mucous membrane pemphigoid to an emergency dental department. Mucous membrane pemphigoid is a rare condition, but its presentation can be severe and concerning for both the patient and clinician. The case presents the manifestations of florid desquamative gingivitis and extensive mucosal erosions due to burst bullae. We discuss the possible causes of the condition in this patient, likely to be the stress of recent cardiac surgery, as well as exploring the efficacy of diagnostic tools, treatment options and adverse effects of corticosteroid treatment. CPD/Clinical Relevance: Correct and timely diagnosis of vesiculobullous disorders has notable impacts on patient outcomes and quality of life.

scholarly journals Assessing the Correlation Between Autoimmune Bullous Disease Quality of Life Questionnaires (ABQOL, TABQOL, DLQI) and Disease Severity Indices in Pemphigus and Bullous Pemphigoid

2020 ◽  
Author(s):  
Shan Cao ◽  
Lulu Sun ◽  
Zhongxiang Shi ◽  
Baoqi Yang ◽  
Furen Zhang
Keyword(s):  
Quality Of Life ◽  
Disease Severity ◽  
Bullous Pemphigoid ◽  
Strong Correlations ◽  
Disease Area ◽  
Area Index ◽  
Severity Of Disease ◽  
Bullous Disease ◽  
Autoimmune Bullous Disease

Abstract Background: Pemphigus and bullous pemphigoid (BP) are autoimmune blistering diseases (AIBDs) that affect the skin and mucous membranes, and adversely impact quality of life (QOL). Few studies have assessed the correlation between the severity of disease and QOL in patients with pemphigus and BP. Objectives: To identify the correlation between the severity of AIBDs and QOL using the Autoimmune Bullous Disease Quality of Life (ABQOL), Treatment Autoimmune Bullous Disease Quality of Life (TABQOL), and Dermatology Life Quality Index (DLQI) questionnaires in Chinese patients with pemphigus and BP at baseline, and after 1, 3 and 6 months of treatment. Methods: Pemphigus and BP patients were invited to complete the ABQOL, TABQOL, and DLQI questionnaires. We measured the pemphigus disease area index (PDAI), autoimmune bullous skin disorder intensity score (ABSIS), and antibodies of desmoglein1,desmoglein3 (DSG1/DSG3) for pemphigus; and the bullous pemphigoid disease area index (BPDAI), ABSIS, and antibodies of BP180/ BP230 for BP as disease severity indices. The correlations between the severity of disease and QOL were analyzed by Spearman’s correlation coefficient (r). Results: Eighty-five patients were included: 55 with pemphigus and 30 with BP. The pemphigus subtypes included pemphigus vulgaris (PV, n = 32), pemphigus foliaceus (PF, n = 22), and paraneoplastic pemphigus (PNP, n = 1). We found significantly strong correlations between QOL (ABQOL, TABQOL, DLQI) and severity of disease (PDAI/BPDAI, ABSIS) with (r = 0.87, 0.77, 0.83; r = 0.86, 0.73, 0.80) for pemphigus and BP, respectively. Mild or strong correlations were also observed between QOL and antibody titers in pemphigus with DSG1/DSG3(r=0.32/0.36) and BP with BP180/BP230( r = 0.73/0.17) respectively. Conclusion: The QOL of patients with pemphigus and BP decreased with increased severity of the AIBDs. As the disease severity descended, so the QOL improved. The QOL indices should be used in clinical trials and to manage patients’ treatment, especially during the active disease stage, despite the mild correlation observed after 1 month of treatment.The PDAI to be better at assessing disease severity than the ABSIS in patients with pemphigus, and ABSIS are better than BPDAI in BP patients for correlation with the QOL indices.

scholarly journals SciaticNeuralgia an Agonising Encumbrance and its Modern Approach

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Avinash Shankar
Keyword(s):  
Quality Of Life ◽  
Clinical Response ◽  
Medical Diagnosis ◽  
Calcium Supplementation ◽  
Modern Approach ◽  
Excellent Quality ◽  
Post Therapy

Sciatica not a medical diagnosis but is a symptom of an underlying vertebral condition i.e.,-lumbar herniation. dislocated disc, Spondylolisthesis and spinal stenosiswhere usually practiced medicine.Physicaltherapy, surgery and even alternative therapyfails to ensure cure but present regimea composite ofintravenous Calcium supplementation, cholecalciferoland bio neurogen composite achieved grade I clinical response in 93% cases without anywithdrawal. Drug adversity, hepatorenal alteration and recurrence in 5yrs of post therapy follow up with excellent quality of life

Relationship between Clinical Response to Therapy and Health-Related Quality of Life Outcomes in Patients with Moderate to Severe Plaque Psoriasis

Dermatology ◽  
2008 ◽  
Vol 216 (3) ◽  
pp. 260-270 ◽  
Author(s):  
Dennis A. Revicki ◽  
Mary K. Willian ◽  
Alan Menter ◽  
Jean-Hilaire Saurat ◽  
Neesha Harnam ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Response ◽  
Plaque Psoriasis ◽  
Response To Therapy ◽  
Health Related Quality ◽  
Life Outcomes ◽  
Severe Plaque Psoriasis ◽  
Related Quality ◽  
Health Related
Sign in / Sign up

Export Citation Format

Share Document