scholarly journals Skin cancers in lockdown: no impact on pathological tumour staging

2021 ◽  
Author(s):  
N. Gaunt ◽  
R.L. Green ◽  
L.F. Motta ◽  
L.A. Jamieson
Keyword(s):  
Tumour Staging ◽  
Skin Cancers

scholarly journals 18 The Impact of Social Deprivation on TNM Staging of Non-Melanoma Skin Cancers: An Initial Review

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
J Miles
Keyword(s):  
Social Deprivation ◽  
Tnm Staging ◽  
Squamous Cell Carcinomas ◽  
Tumour Staging ◽  
Socioeconomic Groups ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
The Uk ◽  
The Impact ◽  
Melanoma Skin

Abstract Aim Over 150,000 cases of non-melanoma skin cancer (NMSC) are diagnosed per year in the UK [1], with greatest incidence in less deprived socioeconomic groups [2]. The association between social deprivation and melanoma staging has been reported [3], however is not as well considered in Basal or Squamous Cell Carcinomas (BCCs/SCCs). Method A pilot review of 200 NMSC excision biopsies completed at a single hospital was undertaken. Specimens were identified via the histopathology database and included all excising specialities and anatomical locations. Registered postcodes were categorised into a decile via the English Indices of Deprivation 2019 database (1= most deprived, 10= least deprived). Tumour staging was identified from the histopathology report. Results 200 specimens were reviewed including 9 deprivation deciles ranging from Decile 2 to Decile 10. Decile 6 was the most common decile, incorporating 20% of all specimens. pT1 BCCs were the most commonly excised lesion at 68.5%, pT3 BCCs and SCCs were least commonly excised (1.5% of specimens each). Increased proportions of pT2 BCCs and SCCs occurred in less deprived deciles, contrasting with pT3 BCCs which clustered in Deciles 6 and 7. pT3 SCCs comprised 11.1% of excised lesions in Decile 4, the greatest proportion outside of pT1 lesions. Conclusions This initial review suggests that the distribution of NMSC staging is not even across social deprivation levels. Increased proportions of pT2 staged lesions occurred in less deprived cohorts. Further expansion of the dataset is justified to assess the degree to which social deprivation may affect NMSC stage at excision.

Incidental Skin Cancers Common in Referrals

2011 ◽  
Vol 41 (11) ◽  
pp. 26
Author(s):  
MARY ANN MOON
Keyword(s):  
Skin Cancers

Skull Base and Intracranial Invasion Patterns and Survival Outcomes of Non-Melanoma Skin Cancers

2016 ◽  
Vol 77 (S 01) ◽  
Author(s):  
Yusuf Dundar ◽  
Richard Cannon ◽  
Marcus Monroe ◽  
Luke Buckman ◽  
Jason Hunt
Keyword(s):  
Skull Base ◽  
Survival Outcomes ◽  
Skin Cancers ◽  
Invasion Patterns ◽  
Melanoma Skin

Ionic Liquids for Topical Delivery in Cancer

2020 ◽  
Vol 26 (41) ◽  
pp. 7520-7532 ◽  
Author(s):  
Ana Rita Dias ◽  
João Costa-Rodrigues ◽  
Cátia Teixeira ◽  
Cristina Prudêncio ◽  
Paula Gomes ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Clinical Applications ◽  
Great Promise ◽  
Topical Drug Delivery ◽  
Green Solvents ◽  
2Nd Generation ◽  
Windows Of Opportunity ◽  
Pharmaceutical Technology ◽  
Skin Cancers ◽  
Per Se

: The unique properties of ionic liquids make them quite appealing for diverse applications, from “green” solvents (1st generation ionic liquids) to finely tuned materials (2nd generation ionic liquids). A decade ago, a 3rd generation of ionic liquids emerged which is focused on their prospective clinical applications, either as drugs per se or as adjuvants in drug formulations. In recent years, research focused on the use of ionic liquids for topical drug delivery has been increasing and holds great promise towards clinical application against skin cancers. This article highlights the growing relevance of ionic liquids in medicinal chemistry and pharmaceutical technology, which is opening new windows of opportunity.

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