scholarly journals Anti‐C1q autoantibodies may not serve as an adequate biomarker for lung manifestations in systemic sclerosis: a single centre, cross sectional study

2021 ◽  
Author(s):  
D.J. Dijkstra ◽  
S.I.E. Liem ◽  
N.M. van Leeuwen ◽  
C.M. Fehres ◽  
J.K. de Vries‐Bouwstra ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional

scholarly journals SAT0330 NEW IMMUNOMODULATORY COMBINATION THERAPIES IN PATIENTS WITH SYSTEMIC SCLEROSIS: A RETROSPECTIVE CROSS-SECTIONAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1110.1-1111
Author(s):  
J. Qiao ◽  
S. X. Zhang ◽  
T. T. Zhang ◽  
J. Zhang ◽  
M. T. Qiu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Side Effects ◽  
Lymphocyte Subsets ◽  
Cross Sectional Study ◽  
Peripheral Lymphocyte ◽  
High Morbidity ◽  
Combination Therapies ◽  
Sectional Study ◽  
Cross Sectional ◽  
Long Term Treatment

Background:Systemic sclerosis (scleroderma, SSc) is a rare complex connective tissue disease associated with high mortality and high morbidity1. Active SSc are typically treated with immunosuppressants, which may create a variety of severe side-effects, especially for long-term treatment2. As the pathogenesis of SSc is still a matter of debate, growing evidences have focused on the immune disorders3. However, the quantitative status of lymphocyte subsets in SSc patients are unclear and effects of immunomodulatory combination therapies (avoiding side-effects of conventional therapy) on the lymphocyte subsets are unknown.Objectives:To investigate the quantitative status of peripheral lymphocyte subpopulations and CD4+T subsets in SSc patients for the exploration of SSc pathogenesis and evaluate the effects of new immunomodulatory combination therapies on those cells.Methods:From July 2014 to December 2019, total 166 patients with SSc and 206 healthy controls (HCs) were enrolled in this study, in which, 79 follow-up patients received immunomodulatory drugs (IMiDs) such as low-dose interleukin-2, rapamycin, metformin, retinoic acid and coenzyme Q10. The absolute numbers of T, B, NK, CD4+T, CD8+T, Th1, Th2, Th17 and Tregs in peripheral blood of these subjects were detected by flow cytometry combined with standard absolute counting beads.Results:Patients with SSc had lower absolute counts of total T, NK, Th2, Th17 and Tregs as compared with those of HCs (P<0.05) (Figure 1). After immunomodulatory combination treatments, there were increases in a various of peripheral lymphocyte subsets such as T, B and CD8+T (P< 0.05). Moreover, the increased level of Tregs was much more dramatical than those of other lymphocyte subsets, resulting in the decrease ratios of Teffs/Tregs such as Th1/Tregs and Th2/Tregs and rebuilding immunologic equilibrium (Figure 2).Conclusion:This cross-sectional study clarified the abnormal status of lymphocyte subsets in SSc patients, suggesting lymphocyte subsets, especially Tregs, might be relevant and play a crucial role in the pathogenesis of SSc, thus providing a potential therapeutic target for SSc patients. Immunomodulatory combination therapies effectively increase the level of Tregs as well as other lymphocytes to some degree and maintain the immunologic equilibrium, which may help for SSc patients’ symptom remission.References:[1]Denton CP, Khanna D. Systemic sclerosis. Lancet 2017;390(10103):1685-99. doi: 10.1016/S0140-6736(17)30933-9 [published Online First: 2017/04/18][2]Winthrop KL, Weinblatt ME, Bathon J, et al. Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019. Ann Rheum Dis 2020;79(1):88-93. doi: 10.1136/annrheumdis-2019-216151 [published Online First: 2019/10/31][3]Skaug B, Khanna D, Swindell WR, et al. Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile. Ann Rheum Dis 2019 doi: 10.1136/annrheumdis-2019-215894 [published Online First: 2019/11/27]Acknowledgments :None.Disclosure of Interests:None declared

scholarly journals Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study

2021 ◽  
pp. 101070
Author(s):  
Laura A. Benjamin ◽  
Ross W. Paterson ◽  
Rachel Moll ◽  
Charis Pericleous ◽  
Rachel Brown ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Cross Sectional Study ◽  
Neurological Manifestations ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional

scholarly journals ABDOMINAL VERSUS VAGINAL HYSTERECTOMY;

2008 ◽  
Vol 15 (04) ◽  
pp. 486-491
Author(s):  
MUHAMMAD IKRAM ◽  
ZOONA SAEED ◽  
ROOHI SAEED ◽  
Uhammad Saeed
Keyword(s):  
Vaginal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Audit Report ◽  
Single Centre ◽  
Cross Sectional ◽  
Main Indication ◽  
Operative Complication

Objective: To evaluate abdominal versus vaginal hysterectomy in relation to operative and post operative complications.Design: Single centre cross sectional study. Place and duration: The Department of Obstetric and Gynaecology, Shaikh Zayed post graduateMedical institute and Hospital, Lahore from 1 November 2005 to 31 October 2006. Subject and methods: All the patients with benign st stindications for hysterectomy (abdominal and vaginal) were included except patients with serious / complicated medical disease. Relativeinformations were filled in a Performa and informations were taken from case records. Results: This audit report included 200 women. 23.3%patients of vaginal hysterectomy were in the age group of 40-45 years while 35.7%patients of abdominal hysterectomy were in the age of 51-55years. Main indication for abdominal hysterectomy (85.5%) was fibroid uterus while for vaginal hysterectomy (66.6%) was Uterovaginal prolapse.Most common immediate post operative complication in abdominal and vaginal hysterectomy was fever in 42.8% and 20.0% respectively.Intraoperative visceral injuries were done in 4 patients in abdominal hysterectomy while no injury was done in vaginal hysterectomy. 44(80%)patients of vaginal hysterectomy were discharged with in 7 days of hospitalization while 64 (44%) patients of abdominal hysterectomy weredischarged with in 7 days of hospitalization. Conclusion: Hysterectomy either abdominal or vaginal is very safe and there were no lethalcomplication except few minor complications and also there was no mortality.

scholarly journals Prevalence of potentially inappropriate medications at admission and discharge among hospitalised elderly patients with acute medical illness at a single centre in Japan: a retrospective cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021152 ◽  
Author(s):  
Junpei Komagamine
Keyword(s):  
Elderly Patients ◽  
Cross Sectional Study ◽  
Medical Illness ◽  
Potentially Inappropriate Medications ◽  
Sectional Study ◽  
Single Centre ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Hospitalised Patients ◽  
Inappropriate Medications

ObjectiveTo determine the prevalence of potentially inappropriate medications (PIMs) at admission and discharge among hospitalised elderly patients with acute medical illness in Japan.DesignA retrospective single-centre cross-sectional study.ParticipantsHospitalised patients aged 65 years or older admitted for pneumonia, heart failure, ischaemic stroke, acute coronary syndrome, chronic obstructive pulmonary disease or asthma, gastrointestinal bleeding, urinary tract infection or epilepsy from September 2014 to June 2016 who were still alive at discharge.Main outcome measuresThe primary outcome was the proportion of patients taking at least one PIM at admission and discharge. PIMs were defined based on the 2015 American Geriatric Society Beers Criteria. Temporal changes in the proportion of patients taking at least one PIM from admission to discharge were also evaluated.ResultsDuring the study period, 689 eligible patients were identified. The median patient age was 82.0 years (IQR 76.0–88.0), 348 (50.5%) were men and the median number of medications at admission was 5.0 (IQR 3.0–8.0). The proportions of patients taking any PIMs at admission and discharge were 47.9% (95% CI 44.2% to 51.6%) and 25.1% (95% CI 21.9% to 28.4%), respectively. The proportion of patients taking any PIMs was significantly lower at discharge than at admission (reduction rate 0.48, 95%, CI 0.41 to 0.53).ConclusionsA substantial proportion of hospitalised elderly patients with acute medical illness took PIMs at admission and discharge. These findings should be confirmed at other hospitals in Japan.

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