Not all melanomas are created equal: A review and call for more research into nodular melanoma

2021 ◽  
Author(s):  
C. Dessinioti ◽  
A.C. Geller ◽  
D.C. Whiteman ◽  
C. Garbe ◽  
J.J. Grob ◽  
...  
Keyword(s):  
Nodular Melanoma

scholarly journals Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ridwan Dwi Saputro ◽  
Hanggoro Tri Rinonce ◽  
Yayuk Iramawasita ◽  
Muhammad Rasyid Ridho ◽  
Maria Fransiska Pudjohartono ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Median Survival ◽  
Therapy Response ◽  
Mrna Levels ◽  
Strongly Correlated ◽  
Clinicopathologic Characteristics ◽  
Tissue Samples ◽  
Nodular Melanoma ◽  
Melanoma Patients ◽  
Melanoma Tissue

Abstract Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue with clinicopathologic characteristics and survival in Indonesian primary nodular melanoma patients. Results Thirty-one tissue samples were obtained; two were excluded from survival analysis due to Breslow depth of less than 4 mm. The median survival of upregulated and normoregulated PD-L1-patients were 15.800 ± 2.345 and 28.945 ± 4.126 months, respectively. However, this difference was not significant statistically (p = 0.086). Upregulated and normoregulated NKG2A patients differed very little in median survival time (25.943 ± 7.415 vs 26.470 ± 3.854 months; p = 0.981). Expression of PD-L1 and NKG2A were strongly correlated (rs: 0.787, p < 0.001). No clinicopathologic associations with PD-L1 and NKG2A mRNA levels were observed. These results suggest that PD-L1 may have potential as a prognostic factor. Although an unlikely prognostic factor, NKG2A may become an adjunct target for therapy. The strong correlation between PD-L1 and NKG2A suggests that anti-PD-1 and anti-NKG2A agents could be effective in patients with PD-L1 upregulation. The mRNA levels of these two genes may help direct choice of immunotherapy and predict patient outcomes.

scholarly journals Case report of nodular melanoma within congenital melanocytic nevus- primary closure challenge

2016 ◽  
Vol 20 ◽  
pp. 84-86
Author(s):  
Domagoj Eljuga ◽  
Ivan Milas ◽  
Iva Kirac ◽  
Mladen Stanec ◽  
Danko Velimir Vrdoljak
Keyword(s):  
Case Report ◽  
Primary Closure ◽  
Melanocytic Nevus ◽  
Congenital Melanocytic Nevus ◽  
Nodular Melanoma

scholarly journals RSK1 Activation Promotes Invasion in Nodular Melanoma

2015 ◽  
Vol 185 (3) ◽  
pp. 704-716 ◽  
Author(s):  
Amel Salhi ◽  
Joshua A. Farhadian ◽  
Keith M. Giles ◽  
Eleazar Vega-Saenz de Miera ◽  
Ines P. Silva ◽  
...  
Keyword(s):  
Nodular Melanoma

scholarly journals BRAF-V600E expression in primary nodular melanoma is associated with aggressive tumour features and reduced survival

2016 ◽  
Vol 114 (7) ◽  
pp. 801-808 ◽  
Author(s):  
Emilia Hugdahl ◽  
May Britt Kalvenes ◽  
Hanne E Puntervoll ◽  
Rita G Ladstein ◽  
Lars A Akslen
Keyword(s):  
Braf V600e ◽  
Nodular Melanoma

Nodular melanoma presenting as an exophytic subungual mass

2018 ◽  
Vol 63 (1) ◽  
pp. 32-34 ◽  
Author(s):  
B Finlay ◽  
T Ramachandren ◽  
K Hussey ◽  
S Parkyn ◽  
K Meyer ◽  
...  
Keyword(s):  
Delayed Diagnosis ◽  
Interesting Case ◽  
High Index ◽  
Nodular Melanoma ◽  
Diagnostic Pitfall ◽  
One Year ◽  
High Index Of Suspicion ◽  
Subungual Melanoma

Despite being recognised and reported in the literature for decades, subungual melanoma of the foot remains a diagnostic pitfall, with it commonly being mistaken for benign conditions. We present an interesting case of delayed diagnosis of subungual melanoma of the hallux that was misdiagnosed in the community for over one year. With melanoma being the fourth most commonly diagnosed cancer in Australia in 2013, this case serves as a reminder to all clinicians about the importance of maintaining a high index of suspicion for melanoma of the foot.

scholarly journals Potential prognostic value of PD-L1 and NKG2A expression in Indonesian patients with skin nodular melanoma

2021 ◽  
Author(s):  
Ridwan Dwi Saputro ◽  
Hanggoro Tri Rinonce ◽  
Yayuk Iramawasita ◽  
Muhammad Rasyid Ridho ◽  
Maria Fransiska Pudjohartono ◽  
...  
Keyword(s):  
Target Genes ◽  
Therapy Response ◽  
Mrna Levels ◽  
Independent Predictive Factor ◽  
Clinicopathologic Characteristics ◽  
Tissue Samples ◽  
Nodular Melanoma ◽  
Expression Levels ◽  
Melanoma Tissue

Abstract Objective Biomarker mRNA levels have been suggested to be predictors of patient survival and therapy response in melanoma cases. This study aimed to investigate the correlations between the mRNA expression levels of PD-L1 and NKG2A in melanoma tissue and clinicopathologic characteristics and survival in Indonesian patients with primary nodular melanoma. Results Thirty-two tissue samples were analyzed. Upregulated PD-L1 was associated with shorter overall survival (hazard ratio: 2.930; 95% confidence interval: 1.011–8.489, p = 0.048) compared with patients with normoregulated PD-L1. A significant positive correlation was found between the expression levels of PD-L1 and NKG2A (rs: 0.768, p < 0.001). However, no clinicopathologic associations with PD-L1 and NKG2A mRNA levels were statistically proven. Comparison with other studies suggested that the choice of adjuvant therapy and the presence of TILs affect the prognostic role of PD-L1 expression. NKG2A was not proven to be an independent predictive factor but may become an adjunct target for therapy. The strong correlation between PD-L1 and NKG2A suggests that anti-PD-1 and anti-NKG2A agents could be effective in patients with PD-L1 upregulation. The combination of the mRNA levels of these two target genes may provide a novel prognostic and therapeutic direction for immunotherapy.

scholarly journals Nodular melanoma: five consecutive cases in a general practice with polarized and non-polarized dermatoscopy and dermatopathology

2014 ◽  
Author(s):  
Cliff Rosendahl ◽  
Matthew Hishon ◽  
Alan Cameron ◽  
Sarah Barksdale ◽  
David Weedon ◽  
...  
Keyword(s):  
General Practice ◽  
Nodular Melanoma
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