scholarly journals Microwave therapy: A new treatment for precancerous skin lesions (actinic keratoses)

2020 ◽  
Vol 183 (2) ◽  
Keyword(s):  
Skin Lesions ◽  
Actinic Keratoses ◽  
New Treatment ◽  
Microwave Therapy

Ingenol Mebutate: A Promising Treatment for Actinic Keratoses and Nonmelanoma Skin Cancers

2013 ◽  
Vol 17 (3) ◽  
pp. 173-179 ◽  
Author(s):  
Aditya K. Gupta ◽  
Maryse Paquet
Keyword(s):  
Safety Data ◽  
Mechanisms Of Action ◽  
Scientific Meeting ◽  
Ingenol Mebutate ◽  
Actinic Keratoses ◽  
Skin Cancers ◽  
The Us ◽  
New Treatment ◽  
Skin Conditions ◽  
Nonmelanoma Skin Cancers

Background: A new treatment for actinic keratoses, ingenol mebutate, was recently approved by the US Food and Drug Administration. Objective: To review the mechanisms of action, efficacy and safety data, and practical recommendations for ingenol mebutate. Methods: The PubMed and clinicaltrials.gov databases were searched in March/April 2012 using the terms PEP005, ingenol mebutate, and ingenol 3-angelate. The abstracts from the Annual Scientific Meeting of the Australian College of Dermatologists (2009–2011) and the Annual Meeting of the American Academy of Dermatology (2009–2012) were also searched. Results: Due to its multiple mechanisms of action, ingenol mebutate treatment resulted in short- and long-term efficacy similar to other topical treatments for actinic keratoses in a shorter period of 2 or 3 days. This short therapy would reduce the duration of adverse events. Premarketing trials for treatment of nonmelanoma skin cancers also showed promising results for ingenol mebutate. Conclusion: Ingenol mebutate is a convenient, safe, and effective intervention for precancerous and cancerous skin conditions.

Graft Versus Host Disease after Granulocyte Infusion.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5266-5266
Author(s):  
Cristina Barrenetxea ◽  
Francisco J. Zuazu ◽  
Javier Bueno ◽  
Antonio Julia ◽  
Jose L. Diaz
Keyword(s):  
Complete Remission ◽  
Graft Versus Host Disease ◽  
Hematopoietic Cell Transplantation ◽  
Rare Event ◽  
Skin Lesions ◽  
Solid Organ ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
New Treatment

Abstract INTRODUCTION Graft versus host disease (GVHD) occurs when immunologycally competent cells are introduced into an immunoincompetent host. GVHD refers to both the immunologic insult and the consequences to the organism. The leading cause of GVHD is hematopoietic cell transplantation (HCT), other causes like solid organ transplants, blood transfusions, and maternal-fetal transfusions also reportedly cause GVHD. CASE We present a 33 years old man, who was diagnosed in October 1997 of acute myeloid leukemia, treated with idarrubicin, etoposid and citarabine (IDICE), with complete remission; after that he received intensification treatment with mitoxanthrone and citarabine, and consolidation with an allogeneic HSCT from a sibling donor. The chimerism was 100% of the donor since first month. There wasn’t any important complications after HSCT; except a GVHD skin, resolved with corticoids. Seven years after HCST, in November 2004, a routine control detected donor’s chimerism 34% with a medullar relapse. Leukemia characteristics were the same than the initials, and a new treatment with IDICE was administrated, showing no response, therefore, a second cycle was administrated. One week after the first treatment fever appeared, which persisted besides large spectre antibiotics, so empiric antifungal treatment was added. Two months after the relapse the patient remained febrile, and skin lesions appeared in head, arms, legs, abdomen and oral mucosa. A biopsy was performed and diagnosed with Fusarium sp. The neutropenia persisted, and the overall status was worsening, so we decided donor granulocyte infusions from two HLA identical sisters; ten days later, neutropenia disappeared, the bone marrow hadn’t blastic cells, and chimerism was 100% donor. A month later, new skin lesions appeared, the biopsy confirmed GVHD and severe liver affectation was also demonstrated by biopsy. It was treated with corticoids and cyclosporine, with rapid resolution. The patient left hospital, and until now chimerism remains 100% donor with complete remission, without treatment for GVHD. CONCLUSION: Graft versus Host disease is usually presented after hematopoietic stem cells infusion but other causes are been reported as lymphocytes infusion, where is not a rare event, and in other cases as granulocytes infusion as in our patient. GVHD after granulocyte infusion is not a common complication even though it has to be taken in mind in patients that show skin or liver affectation after infusion.

scholarly journals Pruritic Urticarial Papules and Plaques of Pregnancy Occurring Postpartum Treated with Intramuscular Injection of Autologous Whole Blood

2017 ◽  
Vol 9 (1) ◽  
pp. 151-156 ◽  
Author(s):  
En Hyung Kim
Keyword(s):  
Whole Blood ◽  
Intramuscular Injection ◽  
Treatment Options ◽  
Skin Lesions ◽  
Negative Effects ◽  
Systemic Corticosteroids ◽  
Alternative Treatment Option ◽  
Autologous Whole Blood ◽  
New Treatment ◽  
Patient Concerns

Pruritic urticarial papules and plaques of pregnancy (PUPPP) is one of the most common diseases associated with pregnancy. In most cases, the skin lesions develop in the third trimester of primigravidas. There are no systemic alterations seen in PUPPP; however, most patients report severe pruritus. A 34-year-old woman presented 1 week postpartum with typical clinical features of PUPPP. The patient showed good response to intramuscular injection of autologous whole blood with no adverse effects to the patient or her baby. Presentation of PUPPP in the postpartum period is rare. Conservative management with topical corticosteroids and oral antihistamines is commonly used to relieve pruritus. In severe cases, skin lesions and symptoms are controlled with a brief course of systemic corticosteroids. Investigation of new treatment options has been limited by patient concerns about the negative effects of medication on the fetus or breastfeeding. Intramuscular injection of autologous whole blood could be an alternative treatment option for PUPPP, especially for women who worry about the use of medications during pregnancy or breastfeeding.

scholarly journals 2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice

2021 ◽  
Author(s):  
Lihua Hao ◽  
Yuancheng Mao ◽  
Jin Park ◽  
Byoung-Mog Kwon ◽  
Eun Ju Bae ◽  
...  
Keyword(s):  
T Cell Activation ◽  
Cell Activation ◽  
Intraperitoneal Administration ◽  
Inflammatory Cells ◽  
Stem Bark ◽  
Skin Lesions ◽  
Stat3 Signaling ◽  
Anticancer Effects ◽  
Th17 Cell Differentiation ◽  
New Treatment

Abstract2′-Hydroxycinnamaldehyde (HCA), the active component isolated from the stem bark of Cinnamomum cassia, exerts anticancer effects through multiple mechanisms. We recently determined that HCA inhibits signal transducer and activator of transcription 3 (STAT3) signaling in prostate cancer cells. Because STAT3 overactivation has been closely associated with the development of psoriasis, a chronic autoimmune skin disease, we examined whether HCA ameliorates skin lesions in an imiquimod-induced psoriasis-like mouse model. The results showed that intraperitoneal administration of HCA alleviated imiquimod-induced psoriasis-like dermatitis, epidermal thickening, dermal infiltration of inflammatory cells, and proinflammatory cytokine production. Mechanistically, HCA inhibited pyruvate kinase isozyme M2 and STAT3 signaling, leading to the suppression of T cell activation, Th17 cell differentiation, and keratinocyte hyperproliferation. These results suggest that HCA may be a new treatment for psoriasis and other STAT3-mediated skin disorders, such as infection, inflammation and carcinogenesis.

scholarly journals Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review

2019 ◽  
Vol 11 (1) ◽  
pp. 16-22
Author(s):  
Alise Balcere ◽  
Raimonds Karls ◽  
Ingrīda Čēma ◽  
Māra Rone Kupfere ◽  
Ludmila Vīksna ◽  
...  
Keyword(s):  
Case Report ◽  
Basal Cell ◽  
Chronic Exposure ◽  
Skin Lesions ◽  
Anatomical Site ◽  
Single Individual ◽  
Actinic Keratoses ◽  
Close Proximity ◽  
Basal Cell Carcinomas ◽  
Topical Chemotherapy

Chronic exposure to ultraviolet radiation induces gradual changes in cutaneous morphology, which with increasing damage leads to the appearance of cancerous skin lesions. Among them, basal cell carcinomas (BCCs) and actinic keratoses (AKs) are the most common entities. Both lesions often develop as two separate lesions in a single individual at a conspicuous distance, close proximity or as collision lesions, which are characterized by the coexistence of both cancers in the same anatomical site. Collision lesions in which AK precisely overlies BCC is a rarely reported entity. We report a case where the presence of BCC was dermatoscopically detected after an overlying AK was treated with topical chemotherapy, thus indicating that treatment of AK allows better visualization of other underlying malignancies.

scholarly journals Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil

2009 ◽  
Vol 25 (5) ◽  
pp. 965-971 ◽  
Author(s):  
Priscila Ishioka ◽  
Sílvio Alencar Marques ◽  
Amélia Toyomi Hirai ◽  
Mariangela E. A. Marques ◽  
Sérgio Henrique Hirata ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Actinic Keratosis ◽  
Skin Lesions ◽  
Sao Paulo ◽  
São Paulo ◽  
Actinic Keratoses ◽  
Paulo State ◽  
Non Melanoma Skin Cancer ◽  
Japanese Brazilians ◽  
Melanoma Skin

Precancerous lesions and skin cancer are infrequent in Asians, and have received little documentation in the literature. Brazil has the world's largest contingent of Japanese immigrants and their descendants, and 70% live in the State of São Paulo. The prevalence of such skin lesions in Japanese-Brazilians is unknown. This study aimed to assess the prevalence of actinic keratoses and non-melanoma skin cancer in first and second-generation Japanese-Brazilians over 30 years of age, without miscegenation, living in the city of Bauru, São Paulo State, in 2006. Of the 567 Japanese-Brazilians that underwent dermatological examination, actinic keratosis was diagnosed in 76, with a mean age of 68.9 years, and a single case of basal cell carcinoma was detected in a 39-year-old female patient. In Japan, prevalence of actinic keratosis varies from 0.76% to 5%, and the incidence of non-melanoma skin cancer is 1.2 to 5.4/100 thousand. Japanese-Brazilians from Bauru showed a 13.4% prevalence of actinic keratoses and earlier age at onset. Proximity to the Equator and a history of farming contribute to these higher rates. Presence of solar melanosis was associated with a 1.9-fold risk of developing actinic keratosis.

Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

1977 ◽  
Vol 35 ◽  
pp. 498-499
Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza
Keyword(s):  
Feed Efficiency ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Skin Lesions ◽  
Hepatic Necrosis ◽  
Ultrastructural Changes ◽  
Lymphoid Tissues ◽  
Heat Transfer Fluids ◽  
Thyroid Follicular Cells ◽  
Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

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