scholarly journals High somatostatin receptor expression and efficacy of somatostatin analogues in patients with metastatic Merkel cell carcinoma

2020 ◽  
Author(s):  
T. Akaike ◽  
J. Qazi ◽  
A. Anderson ◽  
F.S. Behnia ◽  
M.M. Shinohara ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Somatostatin Receptor ◽  
Somatostatin Analogues ◽  
Receptor Expression ◽  
Merkel Cell

scholarly journals Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Kristina Buder ◽  
Constantin Lapa ◽  
Michael C Kreissl ◽  
Andreas Schirbel ◽  
Ken Herrmann ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Expression ◽  
Merkel Cell

CD117 (KIT Receptor) Expression in Merkel Cell Carcinoma

2002 ◽  
Vol 24 (4) ◽  
pp. 289-293 ◽  
Author(s):  
Lyndon D. Su ◽  
Douglas R. Fullen ◽  
Lori Lowe ◽  
Patricia Uherova ◽  
Bertram Schnitzer ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Receptor Expression ◽  
Merkel Cell ◽  
Kit Receptor

Acetylcholine Receptor Expression in Merkel Cell Carcinoma

2008 ◽  
Vol 30 (4) ◽  
pp. 340-343 ◽  
Author(s):  
Jeremy W Bowers ◽  
Scott M Schlauder ◽  
Kenneth B Calder ◽  
Michael B Morgan
Keyword(s):  
Cell Carcinoma ◽  
Acetylcholine Receptor ◽  
Merkel Cell Carcinoma ◽  
Receptor Expression ◽  
Merkel Cell

Clinical Experience on Eight Cases of Merkel Cell Carcinoma

2003 ◽  
Vol 89 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Fernando Cirillo ◽  
Massimo Buononato ◽  
Gianfranco Lima ◽  
Ines Cafaro ◽  
Palmiro Alquati
Keyword(s):  
Quality Of Life ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Average Diameter ◽  
Somatostatin Analogues ◽  
Neuroendocrine Neoplasm ◽  
Merkel Cell ◽  
Immune Disorder ◽  
Over Time

Merkel cell carcinoma is a rare neuroendocrine neoplasm of the skin. The tumor most frequently affects elderly patients, with a preference for the head and neck. Eight patients affected by Merkel cell carcinoma have been observed at the General Surgery Unit II of the “Istituti Ospitalieri” hospital in Cremona, each in different stages of the disease; 75% of the cases involved the extremities, and in nearly all of the cases the tumor was nodular in appearance, with an average diameter of 2.2 cm. In 2 cases, the tumor was associated with rheumatoid arthritis, suggesting a dependency on the part of the neoplasm on the immune disorder and on steroid treatment. The available data confirm that in stage I of the disease, surgical treatment should be associated with radiotherapy in order to control the development of local relapses or metastases over time. In this stage, we observed a survival of 34 months (range, 24-48). In stages II and III, survival time falls, with very short duration of responses and poor quality of life as a result of the administration of cytotoxic molecules. Bearing in mind that any local relapse tends to appear within 12 months of the removal of the primitive tumor, that lymph node metastases appear in almost half of the patients, and that metastases over time are manifested in over a third of patients, it is essential to adopt a treatment capable of balancing the demand for longer remissions with a better quality of life. In this situation, we observed that treatment with somatostatin analogues achieves interesting responses without side effects, which suggests a close biological relationship between the tumor and somatostatin and that making a careful assessment of the prognostic factors of the disease can guarantee a correct therapeutic choice.

Somatostatin receptor type 2 expression in Merkel cell carcinoma as a prognostic factor

2018 ◽  
Vol 32 (6) ◽  
pp. e236-e237 ◽  
Author(s):  
K.V. Orlova ◽  
V.V. Delektorskaya ◽  
Y.V. Vishnevskaya ◽  
T.T. Kondratieva ◽  
N.F. Orel ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Type ◽  
Merkel Cell

Quantitation of somatostatin receptor type 2 in neuroendocrine (merkel cell) carcinoma of the skin by competitive RT-PCR

1999 ◽  
Vol 10 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Mauro Papotti ◽  
Luigia Macri’ ◽  
Alberto Pagani ◽  
Filippo Aloi ◽  
Gianni Bussolati
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Somatostatin Receptor ◽  
Receptor Type ◽  
Merkel Cell ◽  
Rt Pcr
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