A new model of human telogen–anagen transformation helps decipher Wnt signalling in the human hair cycle

2020 ◽  
Vol 182 (5) ◽  
pp. 1084-1084
Author(s):  
M. Philpott
Keyword(s):  
Human Hair ◽  
Wnt Signalling ◽  
Hair Cycle ◽  
New Model

scholarly journals Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation

2019 ◽  
Vol 182 (5) ◽  
pp. 1184-1193 ◽  
Author(s):  
N.J. Hawkshaw ◽  
J.A. Hardman ◽  
M. Alam ◽  
F. Jimenez ◽  
R. Paus
Keyword(s):  
Human Hair ◽  
Wnt Signalling ◽  
Hair Cycle ◽  
Molecular Morphology

scholarly journals Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle

2021 ◽  
Author(s):  
Megan A. Palmer ◽  
Eleanor Smart ◽  
Iain S. Haslam
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Vital Role ◽  
Transport Proteins ◽  
Hair Follicles ◽  
Regulatory Control ◽  
Cholesterol Transport ◽  
Hair Cycle ◽  
Human Hair Follicle

AbstractCholesterol has long been suspected of influencing hair biology, with dysregulated homeostasis implicated in several disorders of hair growth and cycling. Cholesterol transport proteins play a vital role in the control of cellular cholesterol levels and compartmentalisation. This research aimed to determine the cellular localisation, transport capability and regulatory control of cholesterol transport proteins across the hair cycle. Immunofluorescence microscopy in human hair follicle sections revealed differential expression of ATP-binding cassette (ABC) transporters across the hair cycle. Cholesterol transporter expression (ABCA1, ABCG1, ABCA5 and SCARB1) reduced as hair follicles transitioned from growth to regression. Staining for free cholesterol (filipin) revealed prominent cholesterol striations within the basement membrane of the hair bulb. Liver X receptor agonism demonstrated active regulation of ABCA1 and ABCG1, but not ABCA5 or SCARB1 in human hair follicles and primary keratinocytes. These results demonstrate the capacity of human hair follicles for cholesterol transport and trafficking. Future studies examining the role of cholesterol transport across the hair cycle may shed light on the role of lipid homeostasis in human hair disorders.

scholarly journals Human Hair Cycle

1970 ◽  
Vol 54 (1) ◽  
pp. 65-81 ◽  
Author(s):  
Masaji Saitoh ◽  
Makoto Uzuka ◽  
Masao Sakamoto
Keyword(s):  
Human Hair ◽  
Hair Cycle

scholarly journals Wnt Binding Affinity Prediction for Putative Frizzled-Type Cysteine-Rich Domains

2019 ◽  
Vol 20 (17) ◽  
pp. 4168 ◽  
Author(s):  
Mark Agostino ◽  
Sebastian Öther-Gee Pohl
Keyword(s):  
Binding Energy ◽  
Prediction Model ◽  
Binding Affinity ◽  
Wnt Signalling ◽  
Binding Affinity Prediction ◽  
New Model ◽  
Affinity Prediction ◽  
Frizzled Receptors ◽  
Canonical Wnt ◽  
Related Proteins

Several proteins other than the frizzled receptors (Fzd) and the secreted Frizzled-related proteins (sFRP) contain Fzd-type cysteine-rich domains (CRD). We have termed these domains “putative Fzd-type CRDs”, as the relevance of Wnt signalling in the majority of these is unknown; the RORs, an exception to this, are well known for mediating non-canonical Wnt signalling. In this study, we have predicted the likely binding affinity of all Wnts for all putative Fzd-type CRDs. We applied both our previously determined Wnt‒Fzd CRD binding affinity prediction model, as well as a newly devised model wherein the lipid term was forced to contribute favourably to the predicted binding energy. The results obtained from our new model indicate that certain putative Fzd CRDs are much more likely to bind Wnts, in some cases exhibiting selectivity for specific Wnts. The results of this study inform the investigation of Wnt signalling modulation beyond Fzds and sFRPs.

Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

2002 ◽  
Vol 6 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Marty E. Sawaya ◽  
Ulrike Blume-Peytavi ◽  
Diane L. Mullins ◽  
Bernard P. Nusbaum ◽  
David Whiting ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Time Course ◽  
Central Element ◽  
Constitutive Expression ◽  
Hair Follicles ◽  
Dermal Fibroblasts ◽  
Follicle Cells ◽  
Hair Cycle ◽  
Cellular Expression

Background: A number of studies have provided evidence that apoptosis is a central element in the regulation of hair follicle regression. In androgenetic alopecia (AGA), the exact location and control of key players in the apoptotic pathways remains obscure. Objective: In the present study, we used a panel of antibodies and investigated the spatial and cellular pattern of expression of caspases and inhibitors of apoptosis (IAPs), such as XIAP and FLIP, in men with normal scalp and in men with AGA before and after 6 months of treatment with 1 mg oral finasteride treatment. Methods and Results: Constitutive expression of caspases-1, −3, −8, and −9 and XIAP was detected predominantly within the isthmic and infundibular hair follicle area, basilar layer of the epidermis, and eccrine and sebaceous glands. AGA-affected tissues showed an increase in caspase (−1, −3, −6, −9) immunoreactivity with a concomitant decrease in XIAP staining. After 6 months of finasteride treatment, both caspases and XIAP were similar to levels exhibited by normal subjects. Immunoblot analysis was performed to determine antibody specificity and cellular expression of caspases. Purified populations of keratinocytes, melanocytes, dermal papilla, and dermal fibroblasts derived from human hair follicles were cultured in vitro and treated with 0.5 μm staurosporin. Time-course experiments revealed that processing of caspase-3 is a principal event during apoptosis of these hair cell types. Conclusion: These data suggest that alterations in levels of caspases and IAPs regulate hair follicle homeostasis. Moreover, finasteride appears to influence caspase and XIAP expression in hair follicle cells thus signaling anagen, active growth in the hair cycle.

A prototypic mathematical model of the human hair cycle

2012 ◽  
Vol 310 ◽  
pp. 143-159 ◽  
Author(s):  
Yusur Al-Nuaimi ◽  
Marc Goodfellow ◽  
Ralf Paus ◽  
Gerold Baier
Keyword(s):  
Mathematical Model ◽  
Human Hair ◽  
Hair Cycle
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