scholarly journals Laboratory safety of dupilumab in moderate‐to‐severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS)

2019 ◽  
Vol 182 (5) ◽  
pp. 1120-1135 ◽  
Author(s):  
A. Wollenberg ◽  
L.A. Beck ◽  
A. Blauvelt ◽  
E.L. Simpson ◽  
Z. Chen ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Phase Iii ◽  
Severe Atopic Dermatitis ◽  
Laboratory Safety ◽  
Three Phase ◽  
Phase Iii Trials

scholarly journals P3.01-044 Erlotinib vs Chemotherapy in EGFR Mut+ NSCLC: OS in Three Phase III Trials Adjusting for Post-Progression Treatment Crossover

2017 ◽  
Vol 12 (11) ◽  
pp. S2218
Author(s):  
Y. Wu ◽  
C. Zhou ◽  
M. Truman ◽  
A. Feyereislova ◽  
R. Rossell
Keyword(s):  
Phase Iii ◽  
Three Phase ◽  
Phase Iii Trials

scholarly journals Quality of life and functional outcomes with tapentadol prolonged release in chronic musculoskeletal pain: post hoc analysis

2020 ◽  
Author(s):  
Cesar Margarit Ferri ◽  
Silvia Natoli ◽  
Paz Sanz-Ayan ◽  
Alberto Magni ◽  
Carlos Guerrero ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Phase Iii ◽  
Prolonged Release ◽  
Post Hoc Analysis ◽  
Three Phase ◽  
Sf 36 ◽  
Phase Iii Trials ◽  
Post Hoc

Aims: To investigate quality of life (QOL) and functionality changes in chronic pain during tapentadol prolonged release (PR) treatment. Patients & methods: Post hoc analysis of data from three Phase III trials in patients with osteoarthritis knee pain or low back pain. QOL and functionality changes were assessed by SF-36 scores. Results: All SF-36 subdomain scores improved progressively to week 3 of tapentadol titration and were sustained during 12-week maintenance treatment. Improvements in SF-36 scores were similar between tapentadol dose groups (e.g., 200 to <300 mg vs ≥500 mg), with no greater effect from higher doses. QOL and functionality improvements were consistently greater with tapentadol PR than oxycodone controlled release. Conclusion: Tapentadol PR provides consistent, clinically relevant improvements in QOL and functionality in chronic pain.

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