Thymic stromal lymphopoietin, protease‐activated receptor 2 and interleukin 1 are involved in the relationship between skin irritation and atopic dermatitis

2019 ◽  
Author(s):  
O. Gouin ◽  
L. Misery
Keyword(s):  
Atopic Dermatitis ◽  
Interleukin 1 ◽  
Skin Irritation ◽  
Thymic Stromal Lymphopoietin ◽  
Protease Activated Receptor 2 ◽  
The Relationship

The Relationship between Sensitization to Dust Mite Antigen and Cataract Complications in Patients with Atopic Dermatitis.

1994 ◽  
Vol 56 (6) ◽  
pp. 1167-1171
Author(s):  
Yuka ISHIMOTO ◽  
Shuhei IMAYAMA ◽  
Akito TOSHITANI ◽  
Tetsuya KOGA ◽  
Yumiko KUBOTA ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Dust Mite ◽  
The Relationship

scholarly journals Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jizhe Yu ◽  
Yushuang Qin ◽  
Naxin Zhou
Keyword(s):  
Cell Viability ◽  
Molecular Mechanisms ◽  
Interleukin 1 ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Circular Rnas ◽  
Oa Chondrocytes ◽  
Polymerase Chain ◽  
Apoptosis And Inflammation ◽  
The Relationship

Abstract Background The dysregulation of circular RNAs (circRNAs) has been identified in various human diseases, including osteoarthritis (OA). The purpose of this study was to identify the role and mechanism of circ_SLC39A8 in regulating the progression of OA. Methods The expression levels of circ_SLC39A8, miR-591, and its potential target gene, interleukin-1-receptor-associated kinase 3 (IRAK3), were identified by quantitative real-time polymerase chain reaction (qRT-PCR). Cell viability and apoptosis were determined by Cell Counting Kit-8 (CCK-8) assay and flow cytometry, respectively. The relationship between miR-591 and circ_SLC39A8 or IRAK3 was predicted by bioinformatics tools and verified by dual-luciferase reporter. Results Circ_SLC39A8 and IRAK3 were upregulated and miR-591 was downregulated in OA cartilage tissues. Knockdown of circ_SLC39A8 inhibited apoptosis and inflammation in OA chondrocytes, while these effects were reversed by downregulating miR-591. Promotion cell viability effects of miR-591 were partially reversed by IRAK3 overexpression. Conclusion Our findings indicated that knockdown of circ_SLC39A8 delayed the progression of OA via modulating the miR-591-IRAK3 axis, providing new insight into the molecular mechanisms of OA pathogenesis.

scholarly journals The Relationship between Symptom Flare of Atopic Dermatitis and Airborne Japanese Cedar and Cypress Pollen Counts: A Self-Scoring Diary Study

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Haruko Nishie ◽  
Mariko Kato ◽  
Shiori Kato ◽  
Hiroshi Odajima ◽  
Rumiko Shibata ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Real Time ◽  
Pollen Season ◽  
Airborne Pollen ◽  
Japanese Cedar ◽  
Diary Study ◽  
Pollen Counts ◽  
High Level ◽  
The Relationship

Background. With an increase in Japanese cedar and cypress (JC) pollinosis, the relationship between JC pollen and atopic dermatitis (AD) has been studied. Some reports suggest that JC pollen can be one exacerbating factor for AD, but there has been no report that discusses JC pollen counts relating to AD symptom flare although actual airborne JC pollen counts can widely fluctuate throughout the pollen season. Objective. The relationship between symptom flare of AD and airborne JC pollen counts was examined. Methods. We monitored JC pollen counts in real time and divided the counts into low and high level. We then analyzed self-scored “itch intensity” recorded by 14 AD patients through a self-scoring diary. Results. Among the 14 patients, 7 had significantly higher itch intensity while the pollen counts were high. Conclusion. Even during the pollen season, actual airborne pollen counts can widely fluctuate. Our study suggested that symptom flare of AD could be influenced by the actual pollen counts.

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