scholarly journals Plasma levels of tumour necrosis factor‐α and adiponectin can differentiate patients with psoriatic arthritis from those with psoriasis

2019 ◽  
Vol 181 (2) ◽  
pp. 379-380 ◽  
Author(s):  
C.M. Johnson ◽  
K. Fitch ◽  
J.F. Merola ◽  
J. Han ◽  
A.A. Qureshi ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Tumour Necrosis Factor ◽  
Plasma Levels ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Differential effect of selective block of α2-adrenoreceptors on plasma levels of tumour necrosis factor-α, interleukin-6 and corticosterone induced by bacterial lipopolysaccharide in mice

1995 ◽  
Vol 144 (3) ◽  
pp. 457-462 ◽  
Author(s):  
G Haskó ◽  
I J Elenkov ◽  
V Kvetan ◽  
E S Vizi
Keyword(s):  
Tumour Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumour Necrosis ◽  
Endotoxin Shock ◽  
Bacterial Lipopolysaccharide ◽  
Tumour Necrosis Factor Α ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Abstract The effect of selective block of α2-adrenoreceptors on plasma levels of tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and corticosterone induced by bacterial lipopolysaccharide (LPS) was investigated in mice using ELISA and RIA. It was found that the LPS-induced TNF-α response was significantly blunted in mice pretreated with CH-38083, a novel and highly selective α2-adrenoreceptor antagonist (the α2/α1 ratio is >2000). In contrast, LPS-induced increases in both corticosterone and IL-6 plasma levels were further increased by CH-38083. Since it has recently been shown that the selective block of α2-adrenoreceptors located on noradrenergic axon terminals resulted in an increase in the release of noradrenaline (NA), both in the central and peripheral nervous systems, and, in our experiments, that propranolol prevented the effect of α2-adrenoreceptor blockade on TNF-α plasma levels induced by LPS, it seems likely that the excessive stimulation by NA of β-adrenoreceptors located on cytokine-secreting immune cells is responsible for this action. Since it is generally accepted that increased production of TNF-α is involved in the pathogenesis of inflammation and endotoxin shock on the one hand, and corticosterone and even IL-6 are known to possess anti-inflammatory properties on the other hand, it is suggested that the selective block of α2-adrenoreceptors might be beneficial in the treatment of inflammation and/or endotoxin shock. Journal of Endocrinology (1995) 144, 457–462

Scintigraphy for detecting tumour necrosis factor-α on the skin of patients with psoriatic arthritis

2016 ◽  
Vol 46 (5) ◽  
pp. 377-380 ◽  
Author(s):  
SAL de Souza ◽  
V Nentzinsky ◽  
CCM do Carmo ◽  
L Roimicher ◽  
LMB da Fonseca ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Hepatoprotective effect of tumour necrosis factor α blockade in psoriatic arthritis: a cross-sectional study

2009 ◽  
Vol 69 (6) ◽  
pp. 1148-1150 ◽  
Author(s):  
Michael Seitz ◽  
Stephan Reichenbach ◽  
Burkhard Möller ◽  
Marcel Zwahlen ◽  
Peter M Villiger ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Liver Fibrosis ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Transient Elastography ◽  
Liver Steatosis ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
The Impact ◽  
Necrosis Factor

ObjectiveTo evaluate the impact of tumour necrosis factor α (TNFα) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX).MethodsParticipants were consecutive patients with RA and PsA who had undergone MTX treatment for at least 1 year ± TNF blockade for over 6 months. Liver fibrosis was assessed using non-invasive transient elastography (FibroScan). Regression models were used to compare FibroScan values of patients with RA and patients with PsA receiving TNFα blockers with those who were not.ResultsFibroScan assessments were performed on 51 patients with RA and 43 patients with PsA. Compared to patients with RA, those with PsA were predominantly young men, received lower cumulative dosages of MTX and exhibited a higher incidence of liver steatosis and hyperlipidaemia. An abnormal result was observed in 7.1% of the anti-TNFα-naïve and in 13% of the anti-TNFα-treated patients in the RA group and in 30% of the anti-TNFα-naïve and 4.3% of the anti-TNFα-treated patients in the PsA group (OR=0.11, 95% CI 0.02 to 0.98). Results of the PsA group were robust when adjusted for baseline characteristics.ConclusionThe results suggest a protective effect of TNFα inhibitors against the development of liver fibrosis in patients with PsA.

scholarly journals The influence of obesity on response to tumour necrosis factor-α inhibitors in psoriatic arthritis: results from the DANBIO and ICEBIO registries

Rheumatology ◽  
2016 ◽  
Vol 55 (12) ◽  
pp. 2191-2199 ◽  
Author(s):  
Pil Højgaard ◽  
Bente Glintborg ◽  
Lars Erik Kristensen ◽  
Bjorn Gudbjornsson ◽  
Thorvardur Jon Love ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Tumour necrosis factor-α plasma levels after flavone acetic acid administration in man and mouse

1993 ◽  
Vol 29 (5) ◽  
pp. 729-733 ◽  
Author(s):  
G.G. Chabot ◽  
A. Gouyette ◽  
D. Branellec ◽  
A. Sassi ◽  
S. Chouaib ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Tumour Necrosis Factor ◽  
Plasma Levels ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
Flavone Acetic Acid ◽  
Factor Α ◽  
Acid Administration ◽  
Necrosis Factor
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