Temporal variation of Staphylococcus aureus clonal complexes in atopic dermatitis: a follow‐up study

2018 ◽  
Vol 180 (1) ◽  
pp. 181-186 ◽  
Author(s):  
M.‐L. Clausen ◽  
S.M. Edslev ◽  
L.B. Nørreslet ◽  
J.A. Sørensen ◽  
P.S. Andersen ◽  
...  
Dermatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Minke M.F. van Mierlo ◽  
Suzanne G.M.A. Pasmans ◽  
Joan E.E. Totté ◽  
Jill de Wit ◽  
Bjorn L. Herpers ◽  
...  

<b><i>Background:</i></b> <i>Staphylococcus aureus</i> colonization is associated with disease severity in patients with atopic dermatitis (AD). <b><i>Objective:</i></b> To investigate temporal variation in <i>S. aureus</i> protein A gene (<i>spa)</i>-types isolated from the nose and lesional skin and the correlation of <i>spa</i>-types with disease severity. <b><i>Results:</i></b> This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different <i>spa</i>-types were detected in the nose and skin cultures. Seventy-three patients were colonized with <i>S. aureus</i> in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical <i>spa</i>-types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical <i>spa</i>-types over time. The same <i>spa</i>-type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific <i>spa</i>-types or with temporal variation in <i>spa</i>-type. <b><i>Conclusion:</i></b> <i>S. aureus</i> strains in AD are highly heterogeneous between patients. The majority of patients carry the same <i>spa</i>-type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant <i>spa</i>-type or temporal variation is associated with increased disease severity.


2020 ◽  
Vol 83 (6) ◽  
pp. 1616-1624 ◽  
Author(s):  
Sigrun A.J. Schmidt ◽  
Morten Olsen ◽  
Morten Schmidt ◽  
Christian Vestergaard ◽  
Sinéad M. Langan ◽  
...  

2008 ◽  
Vol 159 (4) ◽  
pp. 942-951 ◽  
Author(s):  
S. Reitamo ◽  
M. Rustin ◽  
J. Harper ◽  
K. Kalimo ◽  
A. Rubins ◽  
...  

Dermatitis ◽  
2008 ◽  
Vol 19 (4) ◽  
pp. 218-238
Author(s):  
Outi-Maria Kekki ◽  
Tarja Aaltonen ◽  
Anne Koskinen ◽  
Hannu Kautiainen ◽  
Kristiina Turjanmaa

2019 ◽  
Vol 31 (7) ◽  
pp. 711-715
Author(s):  
Anna Marsakova ◽  
Avraham Kudish ◽  
Spyridon Gkalpakiotis ◽  
Irmgard Jahn ◽  
Petr Arenberger ◽  
...  

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