Effects of neuroimmune axis modulation by aprepitant on antipruritic and global disease severity in patients with cutaneous T-cell lymphoma

2018 ◽  
Vol 178 (5) ◽  
pp. 1221-1222 ◽  
Author(s):  
S.G. Kwatra ◽  
E. Boozalis ◽  
M.M. Kwatra
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Neuroimmune Axis

scholarly journals Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma

Blood ◽  
2018 ◽  
Vol 131 (7) ◽  
pp. 771-781 ◽  
Author(s):  
Rebecca Kohnken ◽  
Jing Wen ◽  
Bethany Mundy-Bosse ◽  
Kathleen McConnell ◽  
Ashleigh Keiter ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Promoter Regions ◽  
Therapeutic Targeting ◽  
Key Points

Key Points CTCL patients have decreased miR-29b levels and increased BRD4 binding occupancy at promoter regions of tumor-associated genes. Therapeutic targeting of miR-29b and BRD4 in CTCL mice results in significantly decreased disease severity and progression.

scholarly journals IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Maria Abreu ◽  
Marta Miranda ◽  
Mafalda Castro ◽  
Iolanda Fernandes ◽  
Renata Cabral ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Severity ◽  
Advanced Disease ◽  
Cell Lymphoma ◽  
Peripheral Blood Leukocyte ◽  
Serum Levels ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Serum Samples

The itch associated with cutaneous T-cell lymphoma (CTCL), including Mycosis Fungoides (MF) and Sézary syndrome (SS), is often severe and poorly responsive to treatment with antihistamines. Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. Serum samples of 27 patients with CTCL (17 MF and 10 SS) and 29 controls (blood donors) were analyzed for interleukin- (IL-) 31 and IL-8; correlations with disease and itch severity were evaluated. IL-31 serum levels were higher in CTCL patients than in controls and higher in SS than in MF. Also, serum IL-31 levels were higher in patients with advanced disease compared to those with early disease, and they correlated positively with lactate dehydrogenase and beta 2-microglobulin levels, as well as with the Sézary cell count. Itch affected 67% of CTCL patients (MF: 47%; SS: 100%). Serum IL-31 levels were higher in itching patients than in controls and in patients without itching. There was no association between serum IL-8 and disease severity, nor with itching. Serum IL-8 levels correlated positively with peripheral blood leukocyte and neutrophil counts in CTCL patients. Our study suggests a role for IL-31 in CTCL-associated itch, especially in advanced disease and SS, offering a rational target for new therapeutic approaches. Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation.

Sign in / Sign up

Export Citation Format

Share Document