Increased frequency of multiple sclerosis among patients with bullous pemphigoid: a population-based cohort study on comorbidities anchored around the diagnosis of bullous pemphigoid

2017 ◽  
Vol 176 (6) ◽  
pp. 1486-1491 ◽  
Author(s):  
L. Kibsgaard ◽  
M. Rasmussen ◽  
A. Lamberg ◽  
M. Deleuran ◽  
A.B. Olesen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Bullous Pemphigoid ◽  
Population Based

Incidence of chronic immune-mediated inflammatory diseases after diagnosis with Kawasaki disease: a population-based cohort study

Rheumatology ◽  
2021 ◽  
Author(s):  
Stephen G Fung ◽  
Richard Webster ◽  
M Ellen Kuenzig ◽  
Braden D Knight ◽  
Michelle Batthish ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Liver Disease ◽  
Kawasaki Disease ◽  
Sclerosing Cholangitis ◽  
Rate Ratio ◽  
Incidence Rate Ratio ◽  
Population Based ◽  
Immune Mediated ◽  
Increased Risk

Abstract Objectives Kawasaki disease (KD) is an immune-mediated vasculitis of childhood with multi-organ inflammation. We determined the risk of subsequent immune-mediated inflammatory disease (IMID), including arthritis, type 1 diabetes, IBD, autoimmune liver disease, primary sclerosing cholangitis and multiple sclerosis. Methods We conducted a matched population-based cohort study using health administrative data from Ontario, Canada. Children aged <18 years born between 1991 and 2016 diagnosed with KD (n = 3753) were matched to 5 non-KD controls from the general population (n = 18 749). We determined the incidence of IMIDs after resolution of KD. Three- and 12-month washout periods were used to exclude KD-related symptoms. Results There was an elevated risk of arthritis in KD patients compared with non-KD controls, starting 3 months after index date [103.0 vs 12.7 per 100 000 person-years (PYs); incidence rate ratio 8.07 (95% CI 4.95, 13.2); hazard ratio 8.08 (95% CI 4.95, 13.2), resulting in the overall incidence of IMIDs being elevated in KD patients (175.1 vs 68.0 per 100 000 PYs; incidence rate ratio 2.58 (95% CI 1.93, 3.43); hazard ratio 2.58, 95% CI 1.94, 3.43]. However, there was no increased risk for diabetes, IBD, autoimmune liver disease, primary sclerosing cholangitis or multiple sclerosis in KD patients. Similar results were observed using a 12-month washout period. Conclusion Children diagnosed with KD were at increased risk of arthritis following the acute KD event, but not other IMIDs. Health-care providers should monitor for arthritis in children following a diagnosis of KD.

Psoriasis is associated with increased risk of bullous pemphigoid: A nationwide population‐based cohort study in Taiwan

2019 ◽  
Vol 46 (7) ◽  
pp. 604-609 ◽  
Author(s):  
Yi‐Hsin Ho ◽  
Hsiao‐Yun Hu ◽  
Yun‐Ting Chang ◽  
Chung‐Pin Li ◽  
Chen‐Yi Wu
Keyword(s):  
Cohort Study ◽  
Bullous Pemphigoid ◽  
Population Based ◽  
Increased Risk

scholarly journals Non-infectious comorbidity in patients with multiple sclerosis: A national cohort study in Sweden

2020 ◽  
Vol 6 (3) ◽  
pp. 205521732094776
Author(s):  
Anna Castelo-Branco ◽  
Flaminia Chiesa ◽  
Camilla E Bengtsson ◽  
Sally Lee ◽  
Neil N Minton ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Improve Patient Care ◽  
Bowel Dysfunction ◽  
Population Based ◽  
Incidence Rates ◽  
Swedish Population ◽  
Comorbidity Burden ◽  
National Cohort ◽  
Rate Ratios

Background Comorbidity is of significant concern in multiple sclerosis (MS). Few population-based studies have reported conditions occurring in MS after diagnosis, especially in contemporary cohorts. Objective To explore incident comorbidity, mortality and hospitalizations in MS, stratified by age and sex. Methods In a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years) and 61,828 matched MS-free individuals were identified between 1 January 2008 and 31 December 2016, using national registers. Incidence rates (IRs) and incidence rate ratios (IRRs) with 95% CI were calculated for each outcome. Results IRs of cardiovascular disease (CVD) were higher among MS patients than MS-free individuals, (major adverse CVD: IRR 1.42; 95% CI 1.12–1.82; hemorrhagic/ischemic stroke: 1.46; 1.05–2.02; transient ischemic attack: 1.65; 1.09–2.50; heart failure: 1.55; 1.15–2.10); venous thromboembolism: 1.42; 1.14–1.77). MS patients also had higher risks of several non-CVDs such as autoimmune conditions (IRR 3.83; 3.01–4.87), bowel dysfunction (2.16; 1.86–2.50), depression (2.38; 2.11–2.68), and fractures (1.32; 1.19–1.47), as well as being hospitalized and to suffer from CVD-related deaths ((1.91; 1.00–3.65), particularly in females (3.57; 1.58–8.06)). Conclusion MS-patients experience a notable comorbidity burden which emphasizes the need for integrated disease management in order to improve patient care and long-term outcomes of MS.

scholarly journals Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population-based cohort study

2017 ◽  
Vol 74 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Irene Eriksson ◽  
Thomas Cars ◽  
Fredrik Piehl ◽  
Rickard E. Malmström ◽  
Björn Wettermark ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Dimethyl Fumarate ◽  
Population Based ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals A Nine-Year Population-Based Cohort Study on the Risk of Multiple Sclerosis in Patients with Optic Neuritis

2013 ◽  
Vol 231 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Lin-Chung Woung ◽  
Pai-Huei Peng ◽  
Chih-Ching Liu ◽  
Ching-Yao Tsai ◽  
Kai-Chen Wang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Optic Neuritis ◽  
Population Based

scholarly journals Statins did not reduce the mortality risk in patients with bullous pemphigoid: A population-based cohort study

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Chen-Yi Wu ◽  
Chun-Ying Wu ◽  
Yi-Hsian Lin ◽  
Yun-Ting Chang
Keyword(s):  
Cohort Study ◽  
Bullous Pemphigoid ◽  
Mortality Risk ◽  
Population Based
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