Neutrophilic eccrine hidradenitis in two patients treated with BRAF inhibitors: a new cutaneous adverse event

2017 ◽  
Vol 176 (6) ◽  
pp. 1645-1648 ◽  
Author(s):  
F. Herms ◽  
N. Franck ◽  
N. Kramkimel ◽  
F. Fichel ◽  
L. Delaval ◽  
...  
Keyword(s):  
Adverse Event ◽  
Braf Inhibitors ◽  
Cutaneous Adverse Event

scholarly journals Localized Cutaneous Adverse Event Induced by Anastrozole as Adjuvant Treatment for Breast Cancer: A Case Report

2019 ◽  
Vol 11 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Aya Tanaka ◽  
Chigusa Yamashita ◽  
Haruna Hinogami ◽  
Hirohiko Shirai ◽  
Jun Yamamura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Adverse Event ◽  
Adjuvant Treatment ◽  
Hormone Receptor ◽  
Vascular Endothelial Cells ◽  
Left Breast ◽  
Receptor Expression ◽  
Hormone Receptor Positive ◽  
Cutaneous Adverse Event

Cutaneous adverse events caused by aromatase inhibitors have been reported to be rare. We describe a rare case of a cutaneous adverse event that developed in a cancer-affected breast after aromatase inhibitor treatment. A 72-year-old postmenopausal female patient who was diagnosed with stage IA breast cancer received anastrozole as adjuvant treatment. Six months after the initiation of anastrozole, she developed an irregularly shaped purpuric plaque with several purpuric papules surrounding the postoperative scar on her left breast. Histological findings revealed capillary vessel proliferation and expansion, with hemorrhage in the superficial dermis. Immunohistochemistry of the skin biopsy specimen revealed hormone receptor expression limited to the vascular endothelial cells of the proliferating and expanding vessels. We believe that anastrozole induced a change in the local estrogen level, which affected the hormone receptor-positive endothelial cells in the dermis near the primary lesion of the breast cancer and caused a cutaneous adverse event only in the aforementioned area.

Severe cutaneous adverse event in a daclizumab-treated multiple sclerosis patient

2019 ◽  
Vol 34 ◽  
pp. 38-40 ◽  
Author(s):  
Johannis A van Rossum ◽  
Marieke A.D. Peters ◽  
Paul van der Valk ◽  
Brigit A. de Jong
Keyword(s):  
Multiple Sclerosis ◽  
Adverse Event ◽  
Multiple Sclerosis Patient ◽  
Cutaneous Adverse Event
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