Lymph node image-guided core-needle biopsy for cutaneous T-cell lymphoma staging

2016 ◽  
Vol 175 (6) ◽  
pp. 1397-1400 ◽  
Author(s):  
M. Battistella ◽  
C. Sallé de Chou ◽  
C. de Bazelaire ◽  
J.M. Cayuela ◽  
E. de Kerviler ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Core Needle ◽  
Image Guided

Lymph Node Histopathologic Findings in Cutaneous T-Cell Lymphoma: A Prognostic Classification System Based on Morphologic Assessment

1992 ◽  
Vol 97 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Eric C. Vonderheid ◽  
Lawrence W. Diamond ◽  
Sue-Min Lai ◽  
Francis Au ◽  
Michael A. Dellavecchia
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Classification System ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Histopathologic Findings

CUTANEOUS T-CELL LYMPHOMA WITH LYMPH NODE METASTASIS IN AN ADULT ADDAX (ADDAX NASOMACULATUS)

2017 ◽  
Vol 48 (3) ◽  
pp. 933-936 ◽  
Author(s):  
Zoltan S. Gyimesi ◽  
Roy B. Burns ◽  
Sheryl Coutermarsh-Ott ◽  
Chris A. Schiller ◽  
Rita McManamon
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Lymph Node Metastasis ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Node Metastasis

scholarly journals Radiographically Negative, Asymptomatic, Sentinel Lymph Node Positive Cutaneous T-Cell Lymphoma in a 3-Year-Old Male: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Jeffrey Carson ◽  
Jiri Bedrnicek ◽  
Shahab Abdessalam
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Sentinel Lymph Node ◽  
Metastatic Disease ◽  
Cell Lymphoma ◽  
Systemic Disease ◽  
Specific Treatment ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Node Positive

We present a case of a 3-year-old male originally diagnosed with a CD30+ anaplastic cutaneous T-cell lymphoma with no evidence of systemic disease after CT scan, PET scan, and bone marrow aspiration. Sentinel lymph node biopsy (SLNB) was performed as an additional step in the workup and showed microscopic disease. Current management/recommendations for cutaneous T-cell lymphoma do not include SLNB. Medical and surgical management of cutaneous malignancies is dramatically different for local versus advanced disease. Therefore adequate evaluation is necessary to properly stage patients for specific treatment. Such distinction in extent of disease suggests more extensive therapy including locoregional radiation and systemic chemotherapy versus local excision only. Two international case reports have described SLNB in cutaneous T-cell lymphoma with one demonstrating evidence of node positive microscopic disease despite a negative metastatic disease workup. This case is being presented as a novel case in a child with implications including lymphoscintigraphy and SLNB as a routine procedure for evaluation and staging of cutaneous T-cell lymphoma if the patient does not demonstrate evidence of metastatic disease on routine workup.

Image guided lymph node core needle biopsy predicts survival in mycosis fungoides and Sézary syndrome

2021 ◽  
Author(s):  
J. Calvani ◽  
A. de Masson ◽  
C. de Margerie‐Mellon ◽  
É. de Kerviler ◽  
C. Ram‐Wolff ◽  
...  
Keyword(s):  
Lymph Node ◽  
Mycosis Fungoides ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Core Needle ◽  
Image Guided

Utility of Percutaneous Image-Guided Biopsy to Diagnose Intraabdominal Lymphoma with Coaxial Core Needles,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4214-4214
Author(s):  
Ikuo Shimizu ◽  
Keijiro Sato ◽  
Yuko Fujikawa ◽  
Toshimitsu Ueki ◽  
Daigo Akahane ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Cell ◽  
Malignant Lymphoma ◽  
Needle Biopsy ◽  
Cell Lymphoma ◽  
Core Needle ◽  
Image Guided ◽  
Therapy Initiation ◽  
Histopathological Evaluation ◽  
Age Range

Abstract Abstract 4214 Introduction: Although pathological diagnosis is an essential component of managing malignant lymphoma and other malignancies, intraabdominal lesions are generally difficult to approach due to the invasiveness of abdominal surgery. We report here the use of percutaneous image-guided coaxial core needle biopsy to obtain intraabdominal specimens. The coaxial method is associated with a lower risk of tumor cell dissemination and allows for repeated biopsies and thus improves the accuracy of pathological or immunohistological diagnosis. To the best of our knowledge, there have been no reports on the feasibility of this technique for diagnosing intraabdominal malignant lymphomas, which typically requires flow cytometry analysis as well as histopathological evaluation. Methods: We retrospectively reviewed consecutive cases involving percutaneous image-guided biopsy to obtain pathological specimens for intraabdominal mass lesions from April 1999 to March 2011 at Nagano Red Cross Hospital, Nagano, Japan. Liver, spleen, kidney, and inguinal node biopsies were excluded. Following local anesthesia, a certified interventional radiologist performed the procedures using a 16 coaxial guide needle (Cook) parallel to the anesthetic needle under computed tomography (CT) or ultrasonography (US). An 18 gauge core needle was inserted to obtain a pathological specimen, following aspiration with a 20 gauge needle for flow cytometry and cytological evaluation. Occlusion materials of the biopsy track were not used. Since laparotomic biopsy was performed for intraabdominal lesions when percutaneous needle biopsy was not indicated due to anatomical difficulties, we compared needle biopsies with simultaneously performed laparotomic biopsies, which led to a diagnosis of lymphoma. Results: During the 12-year period, we performed 66 procedures for 60 patients (32 males, 28 females; median age, 63.5; age range, 16–85). Six patients underwent second or third repeat procedures due to prior inappropriate samplings (5) or relapse (1). The overall diagnostic rate was 86.4% (57/66); there were 56 true positives, 1 true negative, 9 false negatives, and no false positives (sensitivity, 85.9%; specificity, 100%). No patients required additional surgical biopsies. CT and US were used in 51(76%) and 16 (24%) procedures, respectively. There was no statistically significant difference in accuracy between CT and US as an imaging modality. Notably, median interval between recognition of intraabdominal mass and biopsy was only one day (0–24). As for hematological malignancies, 39 patients had malignant lymphoma (diffuse large B cell lymphoma, 16; follicular lymphoma, 12; Hodgkin lymphoma, 3; peripheral T cell lymphoma, 3; small lymphocytic lymphoma, 3; Burkitt lymphoma, 1; extranodal NK/T cell lymphoma, nasal type, 1) including one case with relapse; 45 procedures were performed for these patients. Biopsies were submitted in 43 procedures, and adequate specimens were obtained for histopathological evaluation and diagnosis in 37 (86%). Flow cytometry was used in 39 procedures and detected lymphoma cells in 31 (79.5%). No major adverse events were observed. Twelve patients (9 males and 3 females; median age, 60; age range, 42–72) were eligible for laparotomic biopsy. While every postoperative course was satisfactory, median duration from lesion recognition to therapy initiation for lymphoma cases excluding those who chose watchful wait or refused therapy was significantly shorter for needle biopsies than laparotomy (14 versus 35 days, p<0.001). Conclusions: This is the first report to show the clinical effectiveness of percutaneous image-guided intraabdominal needle biopsy with coaxial core needles for diagnosis of intraabdominal lymphomas. Although no difference was previously reported between coaxial and noncoaxial methods for liver or kidney biopsies (Hatfield et al. AJR 2008), they experienced seven (0.9%) major complications including one death. We identified no major complications using the Cook core needle system in the present study. This method significantly improves the collection of adequate specimens from intraabdominal lymphoma lesions and potentially helps attain immunohistological distinction, allowing for more timely therapy initiation. Disclosures: No relevant conflicts of interest to declare.

Prognostic significance of tumor burden in the blood of patients with erythrodermic primary cutaneous T-cell lymphoma

Blood ◽  
2001 ◽  
Vol 97 (3) ◽  
pp. 624-630 ◽  
Author(s):  
Julia J. Scarisbrick ◽  
Sean Whittaker ◽  
Alun V. Evans ◽  
Elisabeth A. Fraser-Andrews ◽  
Fiona J. Child ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Peripheral Blood ◽  
Cell Lymphoma ◽  
Cell Clone ◽  
Tumor Burden ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Clone ◽  
Lymph Node Stage

Abstract Erythrodermic cutaneous T-cell lymphoma (CTCL) includes patients with erythrodermic mycosis fungoides who may or may not exhibit blood involvement and Sézary syndrome and in whom hematological involvement is, by definition, present at diagnosis. These patients were stratified into 5 hematologic stages (H0-H4) by measuring blood tumor burden, and these data were correlated with survival. The study identified 57 patients: 3 had no evidence of hematologic involvement (H0), 8 had a peripheral blood T-cell clone detected by polymerase chain reaction (PCR) analysis of the T-cell receptor gene and less than 5% Sézary cells on peripheral blood smear (H1), and 14 had either a T-cell clone detected by Southern blot analysis or PCR positivity with more than 5% circulating Sézary cells (H2). Twenty-four patients had absolute Sézary counts of more than 1 × 109 cells per liter (H3), and 8 patients had counts in excess of 10 × 109 cells per liter (H4). The disease-specific death rate was higher with increasing hematologic stage, after correcting for age at diagnosis. A univariate analysis of 30 patients with defined lymph node stage found hematologic stage (P = .045) and lymph node stage (P = .013) but not age (P = .136) to be poor prognostic indicators of survival. Multivariate analysis identified only lymph node stage to be prognostically important, although likelihood ratio tests indicated that hematologic stage provides additional information (P = .035). Increasing tumor burden in blood and lymph nodes of patients with erythrodermic CTCL was associated with a worse prognosis.The data imply that a hematologic staging system could complement existing tumor-node-metastasis staging criteria in erythrodermic CTCL.

DNA-Cytophotometry of Lymph Node Touch Imprints in Cutaneous T-Cell Lymphoma

1988 ◽  
Vol 90 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Stuart R. Lessin ◽  
Gary L. Grove ◽  
Lawrence W. Diamond ◽  
Francis C. Au ◽  
Peter C. Nowell ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Dna Cytophotometry

Total scalp radiation using image-guided IMRT for progressive cutaneous T cell lymphoma

2009 ◽  
Vol 82 (978) ◽  
pp. e122-e125 ◽  
Author(s):  
R S SAMANT ◽  
G W FOX ◽  
L H GERIG ◽  
L A MONTGOMERY ◽  
D S ALLAN
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Image Guided
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