A phase I randomized trial to assess the effect on skin infiltrate thickness and tolerability of topical phosphodiesterase inhibitors in the treatment of psoriasis vulgaris using a modified psoriasis plaque test

2016 ◽  
Vol 175 (3) ◽  
pp. 479-486 ◽  
Author(s):  
S.D. Snape ◽  
W. Wigger-Alberti ◽  
U.M. Goehring
Keyword(s):  
Phase I ◽  
Randomized Trial ◽  
Psoriasis Vulgaris ◽  
Phosphodiesterase Inhibitors ◽  
Psoriasis Plaque ◽  
Plaque Test

Comparison of the Antipsoriatic Effect and Tolerability of Calcipotriol-Containing Products in the Treatment of Psoriasis Vulgaris Using a Modified Psoriasis Plaque Test

2012 ◽  
Vol 32 (9) ◽  
pp. 613-619
Author(s):  
Catherine Queille-Roussel ◽  
Vibeke Hoffmann ◽  
Cecilia Ganslandt ◽  
Klaus Krog Hansen
Keyword(s):  
Psoriasis Vulgaris ◽  
Psoriasis Plaque ◽  
Plaque Test

Phase I randomized trial of liothyronine for remyelination in multiple sclerosis: A dose-ranging study with assessment of reliability of visual outcomes

2020 ◽  
Vol 41 ◽  
pp. 102015 ◽  
Author(s):  
Lindsey Wooliscroft ◽  
Ghadah Altowaijri ◽  
Andrea Hildebrand ◽  
Mary Samuels ◽  
Barry Oken ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Phase I ◽  
Randomized Trial ◽  
Visual Outcomes ◽  
Dose Ranging

Safety and immunogenicity of adjuvanted inactivated split-virion and whole-virion influenza A (H5N1) vaccines in children: A phase I–II randomized trial

Vaccine ◽  
2010 ◽  
Vol 28 (38) ◽  
pp. 6221-6227 ◽  
Author(s):  
Jiang Wu ◽  
Shu-Zhen Liu ◽  
Shan-Shan Dong ◽  
Xiao-Ping Dong ◽  
Wu-Li Zhang ◽  
...  
Keyword(s):  
Phase I ◽  
Randomized Trial ◽  
Influenza A

A randomized trial of a palliative care intervention for patients on phase I studies.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 12001-12001
Author(s):  
Thomas J. Smith ◽  
Vincent Chung ◽  
Mark T. Hughes ◽  
Marianna Koczywas ◽  
Nilofer Saba Azad ◽  
...  
Keyword(s):  
Palliative Care ◽  
Supportive Care ◽  
Phase I ◽  
Usual Care ◽  
Randomized Trial ◽  
Phase 1 ◽  
Quality Care ◽  
Care Plan ◽  
Phase I Clinical Trials ◽  
Care Intervention

12001 Background: The purpose of this study was to test a Palliative Care Intervention for patients with solid tumors enrolled in phase I therapeutic trials. Methods: This randomized trial compared patients accrued to phase I Clinical Trials in groups of Usual Care compared to a Palliative Care Intervention (PCI) in two comprehensive cancer centers. The PCI included assessment of quality of life (QOL) and symptoms, an interdisciplinary meeting to discuss the care plan, including goals of care, and two nurse-delivered teaching sessions. Subjects (n=479) were followed for 24 weeks, with 12 weeks as the primary outcome point. Results: Outcomes revealed that relative to Usual Care, PCI subjects showed less Psychological Distress (1.9 in Intervention and 1.2 in Control pts, p=0.03) and a trend toward improved QOL (3.7 versus 1.6, p=0.07), with differences between sites. We observed high rates of symptom-management admissions (41.3%) and low rates of Advance Directive completion (39%), and use of supportive care services including hospice (30.7%, for only1.2 months duration), despite a median survival for all patients in both groups of 10.1 months from initiating a phase 1 study until death. Patient satisfaction with oncology care was already high at baseline, and we did not see clinically significant changes in those scores by week 12. Conclusions: Palliative care interventions can improve QOL outcomes and distress for patients participating in phase 1 trials. Greater integration of PC is needed to provide quality care to these patients and to support transitions from treatment to supportive care, especially at the end of life. Clinical trial information: NCT01828775 .

scholarly journals Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting

Neurology ◽  
2014 ◽  
Vol 83 (5) ◽  
pp. 413-425 ◽  
Author(s):  
E. Y. Uc ◽  
K. C. Doerschug ◽  
V. Magnotta ◽  
J. D. Dawson ◽  
T. R. Thomsen ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Phase I ◽  
Aerobic Exercise ◽  
Randomized Trial ◽  
Community Setting

scholarly journals Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs

2017 ◽  
Vol 30 (2) ◽  
pp. 102-114 ◽  
Author(s):  
Walter Wigger-Alberti ◽  
Ragna Williams ◽  
Yi-Ling von Mackensen ◽  
Maciej Hoffman-Wecker ◽  
Ulrike Grossmann ◽  
...  
Keyword(s):  
Test Design ◽  
Psoriasis Plaque ◽  
Plaque Test ◽  
Open Application
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