Comparing the effect of bleach and water baths on skin barrier function in atopic dermatitis: a split‐body randomized controlled trial

2016 ◽  
Vol 175 (1) ◽  
pp. 212-214 ◽  
Author(s):  
V.Y. Shi ◽  
N. Foolad ◽  
J.N. Ornelas ◽  
L.A. Hassoun ◽  
G. Monico ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Barrier Function ◽  
Controlled Trial ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Randomized Controlled

scholarly journals Randomized, Controlled Trial Evaluating a Baby Wash Product on Skin Barrier Function in Healthy, Term Neonates

2013 ◽  
Vol 42 (2) ◽  
pp. 203-214 ◽  
Author(s):  
Tina Lavender ◽  
Carol Bedwell ◽  
Stephen A. Roberts ◽  
Anna Hart ◽  
Mark A. Turner ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Barrier Function ◽  
Controlled Trial ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Term Neonates ◽  
Randomized Controlled

Influence of Sunflower Seed Oil on the Skin Barrier Function of Preterm Infants: A Randomized Controlled Trial

Dermatology ◽  
2014 ◽  
Vol 229 (3) ◽  
pp. 230-239 ◽  
Author(s):  
Varvara Kanti ◽  
Claudia Grande ◽  
Andrea Stroux ◽  
Christoph Bührer ◽  
Ulrike Blume-Peytavi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Barrier Function ◽  
Sunflower Seed ◽  
Seed Oil ◽  
Controlled Trial ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Randomized Controlled ◽  
Sunflower Seed Oil

scholarly journals PEBBLES study protocol: a randomised controlled trial to prevent atopic dermatitis, food allergy and sensitisation in infants with a family history of allergic disease using a skin barrier improvement strategy

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e024594 ◽  
Author(s):  
Adrian Lowe ◽  
John Su ◽  
Mimi Tang ◽  
Caroline J Lodge ◽  
Melanie Matheson ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Family History ◽  
Randomised Controlled Trial ◽  
Barrier Function ◽  
Controlled Trial ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
History Of ◽  
Randomised Controlled

IntroductionThe skin is an important barrier against environmental allergens, but infants have relatively impaired skin barrier function. There is evidence that impaired skin barrier function increases the risk of allergic sensitisation, atopic dermatitis (AD) and food allergy. We hypothesise that regular prophylactic use of emollients, particularly those that are designed to improve skin barrier structure and function, will help prevent these conditions. With the aim of determining if application of a ceramide-dominant emollient two times per day reduces the risk of AD and food allergy, we have commenced a multicentre phase III, outcome assessor blinded, randomised controlled trial of this emollient applied from birth to 6 months.Methods and analysisInfants (n=760) with a family history of allergic disease will be recruited from maternity hospitals in Melbourne. The primary outcomes are as follows: the presence of AD, assessed using the UK Working Party criteria, and food allergy using food challenge, in the first 12 months of life as assessed by a blinded study outcome assessor. Secondary outcomes are as follows: food sensitisation (skin prick test), skin barrier function, AD severity, the presence of new onset AD after treatment cessation (between 6 and 12 months) and the presence of parent reported AD/eczema. Recruitment commenced in March 2018.Ethics and disseminationThe PEBBLES Study is approved by the Human Research Ethics Committees of the Royal Children’s Hospital (RCH) (#37090A) and the Mercy Hospital for Women (2018–008). Parents or guardians will provide written informed consent. Outcomes will be disseminated through peer-reviewed publications and presented at scientific conferences.Trial registration numbersACTRN12617001380381 andNCT03667651.

scholarly journals Randomized controlled trial of impact of early regular emollient using on transepidermal water loss and cumulative incidence of atopic dermatitis in infants at risk

2020 ◽  
Vol 17 (1) ◽  
pp. 50-57
Author(s):  
Natalia Begievna Migacheva ◽  
Alexander Viktorovich Zhestkov ◽  
Tatiana Ivanovna Kaganova
Keyword(s):  
Randomized Controlled Trial ◽  
Atopic Dermatitis ◽  
Water Loss ◽  
Barrier Function ◽  
Cumulative Incidence ◽  
Controlled Trial ◽  
Transepidermal Water Loss ◽  
Main Group ◽  
Control Group ◽  
Randomized Controlled

The solution of the problem of atopic dermatitis (AD) prevention is an important task of modern medicine. Recently the idea of early systematic skin care in infants aimed at improving the epidermal barrier function and reducing the risk of AD development is widespread. The aim of the study was to investigate the effect of early regular emollients application in infants at risk on transepidermal water loss (TEWL) and cumulative incidence of AD. Materials and methods. An open randomized controlled trial included 80 healthy newborns (41 girls and 39 boys) with a family history of allergic diseases has been conducted. All participants were divided into main (n=38) and control (n=42) groups. Infants of the main group received emollients application twice per day for 6 months as well as a symbiotic complex from 3 to 6 months daily compared to the no intervention in control group. All infants were followed-up during the first year of life, besides of clinical examination TEWL was assessed as an objective criterion of epidermal barrier function. The main outcome was the development of AD at the age of 12 months. Results. 72 infants have been included into final analysis (35 - main group, 37 - control group). By the end of follow-up 19 patients (26.4%) had confirmed AD, with significant difference in cumulative incidence of AD between group: 37.8% in the main group and 14.3% in control, р

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