Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

2016 ◽  
Vol 174 (6) ◽  
pp. 1299-1307 ◽  
Author(s):  
N.F. Agamia ◽  
D.M. Abdallah ◽  
O. Sorour ◽  
B. Mourad ◽  
D.N. Younan
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Serum Insulin ◽  
Acne Vulgaris ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Insulin Like Growth Factor ◽  
Forkhead Box

scholarly journals a) Influência do índice de massa corporal e da dieta na fisiopatologia da Acne Vulgaris

2017 ◽  
Vol 75 (3) ◽  
Author(s):  
José Pedro Oliveira Pinheiro da Silva ◽  
Glória Maria Cardoso da Cunha Velho
Keyword(s):  
Growth Factor ◽  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Malassezia Furfur ◽  
Insulin Like Growth Factor ◽  
Forkhead Box

Acne vulgaris é uma das patologias dermatológicas mais comuns na população geral, principalmente em adolescentes e jovens adultos. Esta patologia afeta os folículos pilossebáceos através de processos de hiperqueratose, hipersecreção sebácea, colonização microbiana (Propionibacterium acnes e Malassezia furfur) e mecanismos imunológicos e pode ser descrita tanto como inflamatória (pápulas, pústulas ou nódulos) ou não inflamatória (comedões abertos ou fechados). Apesar de não existir mortalidade associada, existe normalmente significativa morbilidade física e psicológica, como cicatrizes permanentes, baixa autoestima, depressão e ansiedade. A fisiopatologia desta doença é multifatorial, sendo que vários estudos provam a importância de vários fatores genéticos e não genéticos, como diversos mecanismos reguladores endócrinos e a dieta, no aparecimento da acne. Estudos associam a dieta ocidental (carbohidratos hiperglicémicos, leite e lacticínios e gorduras saturadas) e o índice de massa corporal excessivo (excesso de peso e obesidade) ao aparecimento de Acne Vulgaris, sendo que existe evidência do papel da hiperinsulinémia e da resistência à insulina nesta associação. Será assim avaliada nesta dissertação a atual literatura que aborda a fisiopatologia da Acne Vulgaris, com especial foco na relação entre os reguladores endócrinos (androgénios e insulin-like growth factor 1) e reguladores celulares (Forkhead box protein 01, kinase proteica Akt) e os diferentes alimentos da dieta, dando relevância às peculiaridades da dieta ocidental e do seu papel no aparecimento de acne nas diferentes pool´s genéticas mundiais. Será também explorada a relação entre o índice de massa corporal e o aparecimento de acne, bem como a importância das adipocinas na etiologia da acne. O objetivo deste trabalho é contribuir para o melhor conhecimento da fisiopatologia desta interessante e frequente patologia. Sendo uma área muito estudada, torna-se fulcral a existência de artigos de revisão, que compilem, sintetizem e ao mesmo tempo analisem criticamente a literatura científica existente.

scholarly journals The Effect of Forkhead Box Class O1, Mammalian Target of Rapamycin Complex 1, Survivin, and Interleukin-17 on the Degree of Acne Vulgaris Based on Serum Levels

2020 ◽  
Vol 8 (B) ◽  
pp. 401-407
Author(s):  
Sri Yusfinah Masfah Hanum ◽  
Ellyza Nasrul ◽  
Nelva Karmila Jusuf ◽  
Eti Yerizel
Keyword(s):  
Acne Vulgaris ◽  
Venous Blood ◽  
Mammalian Target Of Rapamycin ◽  
Serum Levels ◽  
Statistical Test ◽  
Target Of Rapamycin ◽  
Observational Research ◽  
Interleukin 17 ◽  
Cross Sectional ◽  
Forkhead Box

BACKGROUND: Acne vulgaris (AV) is a health problem that is routinely found throughout the world and has an impact on the quality of life of sufferers. Several studies have shown that forkhead box Class O1 (FoxO1), the mammalian target of rapamycin complex 1 (mTORC1), survivin, and interleukin-17 (IL-17) play a role in the pathogenesis of multifactorial AV. AIM: The study aims to determine the relationship between serum levels of FoxO1, mTORC1, survivin, and IL-17 with the severity of AV. METHODS: This is observational research with cross-sectional design. Samples from venous blood sufferers of AV mild, moderate, and severe, each of 20 people were colected. Classification of AV was based on the criteria of Lehmann et al. Examination of serum levels of FoxO1, mTORC1, survivin, and IL-17 using the ELISA technique was done. The statistical test used was the ANOVA test and the Kruskal–Wallis test. RESULTS: The results showed that average levels of FoxO1 decreased with increasing degree of severity of AV. An average increase in mTORC1, survivin, IL-17 levels with an increase in the severity of AV was found. Statistical test results showed a significant correlation of FoxO1, mTORC1, survivin levels, and the severity of AV (p < 0.05). IL-17 levels were not related to the severity of AV (p > 0.05). CONCLUSION: This study concluded that FoxO1 levels decrease at increasing severity. Conversely, levels of mTORC1, survivin, and IL-17 increase with increasing degrees of the severity of AV.

Insulin-Like Growth Factor 1/Mammalian Target of Rapamycin and AMP-Activated Protein Kinase Signaling Involved in the Effects of Metformin in the Human Endometrial Cancer

2016 ◽  
Vol 26 (9) ◽  
pp. 1667-1672 ◽  
Author(s):  
Dongge Cai ◽  
Hongli Sun ◽  
Yanhua Qi ◽  
Xiaogui Zhao ◽  
Minjuan Feng ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Growth Factor ◽  
Protein Kinase ◽  
Molecular Mechanisms ◽  
Pilot Trial ◽  
Plasma Concentrations ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Insulin Like Growth Factor ◽  
Amp Activated Protein Kinase

BackgroundMetformin is a well-tolerated biguanide drug used for decades to treat type 2 diabetes mellitus. In recent years, long-term administration of metformin has been found to reduce carcinogenic risk for cancers derived from various tissues. However, its cellular and molecular mechanisms of anticancer action in the endometrial cancer (EC) have not yet been fully elucidated.Patients and MethodsSixty patients diagnosed as endometrial carcinoma were grouped into (n = 30) and non-treatment mixed (n = 30) for analysis. Thirty healthy donors are control groups. We attempt to investigate the interaction of metformin, insulin-like growth factor 1 (IGF-1) expression, and phosphorylated mammalian target of rapamycin (p-mTOR) and AMP-activated protein kinase (p-AMPK).ResultsWe found that high IGF-1 plasma concentrations in women with EC were reversed by conventional antidiabetic doses of metformin in the present work. In parallel, the activation of AMPK and suppression of mTOR seemed to play an important role for the effect of metformin in patients with EC.ConclusionsThis pilot trial presents biological evidence consistent with antiproliferative effects of metformin in women with EC in the clinical setting.

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