Photodynamic therapy with methyl aminolaevulinate 80 mg g−1for severe facial acne vulgaris: a randomized vehicle-controlled study

2016 ◽  
Vol 174 (4) ◽  
pp. 770-777 ◽  
Author(s):  
D.M. Pariser ◽  
L.F. Eichenfield ◽  
M. Bukhalo ◽  
G. Waterman ◽  
M. Jarratt ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Acne Vulgaris ◽  
Controlled Study ◽  
Facial Acne

scholarly journals Clinical efficacy of 5-aminolevulinic acid photodynamic therapy in the treatment of moderate to severe facial acne vulgaris

2015 ◽  
Vol 10 (3) ◽  
pp. 1194-1198 ◽  
Author(s):  
XIANGQI CHEN ◽  
HONGTAO SONG ◽  
SHENGPING CHEN ◽  
JING ZHANG ◽  
GAOXIANG NIU ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Efficacy ◽  
Aminolevulinic Acid ◽  
Acne Vulgaris ◽  
Facial Acne

scholarly journals Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life

Medicine ◽  
2017 ◽  
Vol 96 (51) ◽  
pp. e9366 ◽  
Author(s):  
Xinghua Xu ◽  
Yi Zheng ◽  
Zigang Zhao ◽  
Xin Zhang ◽  
Pengxiang Liu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Photodynamic Therapy ◽  
Acne Vulgaris ◽  
Facial Acne

scholarly journals Treatment of dental plaque biofilms using photodynamic therapy: a randomised controlled study

2021 ◽  
Author(s):  
A. Alsaif ◽  
J. F. Tahmassebi ◽  
S. R. Wood
Keyword(s):  
Photodynamic Therapy ◽  
Incubation Time ◽  
Dental Plaque ◽  
Continuous Light ◽  
Laser Scanning Microscopy ◽  
Controlled Study ◽  
Bacterial Counts ◽  
Randomised Controlled Study ◽  
Randomised Controlled

Abstract Introduction Photodynamic therapy (PDT) is a treatment modality involving a dye that is activated by exposure to light of a specific wavelength in the presence of oxygen to form oxygen species causing localised damage to microorganisms. Aim To determine the most effective bactericidal incubation and irradiation times of erythrosine-based PDT on in vivo-formed dental plaque biofilms. Methods A randomised controlled study; 18-healthy adult participants wearing intraoral appliances with human enamel slabs to collect dental plaque samples in two separate periods of two weeks each for use in arm-1 and arm-2. These accumulated dental plaque samples were treated with PDT under different experimental conditions. Incubation times with photosensitiser (erythrosine) of 15 min and 2 min were used in arm-1 and arm-2, respectively, followed by light irradiation for either 15 min (continuous) or as a fractionated dose (5 × 30 sec). Following treatment, percentage reductions of total bacterial counts were compared between the different groups. In addition, confocal laser scanning microscopy (CLSM) and LIVE/DEAD® BacLight™ Bacterial Viability Kit were used to visualise the effect of PDT on in vivo-formed biofilms. Results Significant reductions in the percentage of total bacterial counts (~93–95%) of in vivo-formed biofilms were found when using either 2 min or 15min incubation times and applying 15 min continuous light. Although when applying fractionated light, there was more cell death when 15 min incubation time was used (~ 91%) compared with the 2 min incubation time (~ 64%). CLSM results supported these findings. Conclusion Improving the clinical usefulness of PDT by reducing its overall treatment time seems to be promising and effective in killing in vivo-formed dental plaque biofilms.

Sign in / Sign up

Export Citation Format

Share Document