A mouse organotypic tissue culture model for autosomal recessive congenital ichthyosis

2014 ◽  
Vol 171 (6) ◽  
pp. 1347-1357 ◽  
Author(s):  
S. Rosenberger ◽  
A. Dick ◽  
S. Latzko ◽  
I. Hausser ◽  
H.-J. Stark ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Autosomal Recessive ◽  
Organotypic Tissue Culture ◽  
Congenital Ichthyosis ◽  
Culture Model ◽  
Autosomal Recessive Congenital Ichthyosis ◽  
Tissue Culture Model ◽  
Organotypic Tissue

scholarly journals The effect of tissue culture on suture holding strength and degradation in canine tendon

2009 ◽  
Vol 34 (5) ◽  
pp. 643-650 ◽  
Author(s):  
H. OMAE ◽  
C. ZHAO ◽  
Y.-L. SUN ◽  
M. E. ZOBITZ ◽  
S. L. MORAN ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Tensile Load ◽  
Flexor Digitorum Profundus ◽  
Tendon Suture ◽  
Pull Out ◽  
Culture Model ◽  
Static Tensile ◽  
Tissue Culture Model ◽  
Flexor Digitorum ◽  
Pull Out Strength

The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.

Effect of arginine and its metabolites on the rat myocardium in an organotypic tissue culture

2007 ◽  
Vol 415 (1) ◽  
pp. 257-260 ◽  
Author(s):  
N. I. Chalisova ◽  
A. N. Zakutskii ◽  
A. I. Aniskina ◽  
S. V. Filippov ◽  
P. N. Zezyulin ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Rat Myocardium ◽  
Organotypic Tissue Culture ◽  
Organotypic Tissue

scholarly journals Mutations in Transglutaminase 1 Gene in Autosomal Recessive Congenital Ichthyosis in Egyptian Families

2004 ◽  
Vol 20 (6) ◽  
pp. 325-332 ◽  
Author(s):  
R. M. Shawky ◽  
N.S. Sayed ◽  
N.A. Elhawary
Keyword(s):  
Restriction Endonuclease ◽  
Splice Site ◽  
Autosomal Recessive ◽  
Splice Mutation ◽  
The Other ◽  
Splice Acceptor ◽  
Acceptor Splice Site ◽  
Congenital Ichthyosis ◽  
Transglutaminase 1 ◽  
Autosomal Recessive Congenital Ichthyosis

Autosomal recessive congenital ichthyosis (ARCI) is a rare heterogeneous keratinization disorder of the skin. It is clinically divided into 2 subtypes, lamellar ichthyosis (LI) and congenital ichthyosiformis erythroderma (CIE). We investigated forty-three ARCI Egyptian individuals in 16 severe LI, and 10 CIE families. We identified 5 alleles in two Egyptian families as having intron-5/exon-6 splice acceptor mutation recognized by theMspIrestriction endonuclease. This promoted to a frequency of 9.6% for this mutation (5 splice-mutation alleles/52 alleles tested). We extended our previous dataset to update the detection of R142H mutation in 4 CIE Egyptian families and one LI phenotype (frequency of 28.8%; 15/52), whereas we still had no R141H among our Egyptian population. There was no correlation between phenotype and genotype in our study. Surprisingly, the mutant alleles detected in intron-5 acceptor splice-site were associated with the other extreme of CIE phenotypes rather than the severe LI form. We clearly demonstrated that the ARCI Egyptian families in Upper Egypt was ethnically pure and had a tendency not to be a hybrid with other populations in Lower Egypt, Delta zone and Cairo city.

Autosomal recessive congenital ichthyosis: Genomic landscape and phenotypic spectrum in a cohort of 125 consanguineous families

2019 ◽  
Vol 40 (3) ◽  
pp. 288-298 ◽  
Author(s):  
Leila Youssefian ◽  
Hassan Vahidnezhad ◽  
Amir Hossein Saeidian ◽  
Andrew Touati ◽  
Soheila Sotoudeh ◽  
...  
Keyword(s):  
Autosomal Recessive ◽  
Congenital Ichthyosis ◽  
Phenotypic Spectrum ◽  
Genomic Landscape ◽  
Autosomal Recessive Congenital Ichthyosis
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