Extracorporeal photopheresis: a useful therapy for patients with steroid-refractory acute graft-versus-host disease but not for the prevention of the chronic form

2013 ◽  
Vol 169 (2) ◽  
pp. 450-457 ◽  
Author(s):  
P. Rubegni ◽  
L. Feci ◽  
S. Poggiali ◽  
G. Marotta ◽  
G. D'Ascenzo ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Chronic Form ◽  
Graft Versus Host ◽  
Steroid Refractory ◽  
Acute Graft

scholarly journals Experience with the Use of Infliximab and/or Extracorporeal Photopheresis in Steroid-Refractory Acute Graft Versus Host Disease

2018 ◽  
Vol 24 (3) ◽  
pp. S194 ◽  
Author(s):  
Marietta Nygaard ◽  
Tonny Karlsmark ◽  
Niels Smedegaard ◽  
Ida Schjødt ◽  
Lone S. Friis ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Refractory ◽  
Acute Graft

Extracorporeal photopheresis and anticytokine therapy in the treatment of steroid-refractory acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation in children

2016 ◽  
Vol 7 (1) ◽  
pp. 58-64
Author(s):  
Andrey V Kozlov ◽  
Julia G Fedukova ◽  
Tatzana A Bykova ◽  
Ivan S Moiseev ◽  
Marya A Estrina ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Anticytokine Therapy ◽  
Steroid Refractory ◽  
Acute Graft

Allogeneic hematopoietic stem cell transplantation (allo-SCT) is used widely in the management of children with hematological, oncological and inherited diseases. Study to compare efficiency of steroid-refractory acute graft versus host disease treatment (extracorporeal photopheresis (ECP) vs anticytokine therapy) was conducted in Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint Petersburg. Sixty four children were included in the analysis. Patients were divided into two groups: first “group with ECP” (n = 31; 50,5 %) ("ECP group") and second - "group without ECP" (n = 33; 49,5 %). Treatment in the second group consisted of anticytokine therapy (etanercept (n = 12), infliximab (n = 9), daclizumab (n = 8)) and alemtuzumab (n = 4). Ten-year overall survival (OS) of children with steroid-refractory acute graft versus host disease was 39 % without difference in OS between ECP and anticytokine therapy (5-year OS 40 % vs 35 %, p = 0,34). Response rate to the therapy was also the same in both groups (68 % after ECP and 70 % after anticytokine therapy, p = 0,77). Difference in cumulative incidence of relapse in "ECP group" and "group without ECP" was not statistically significant (18 % and 7 %, respectively, p = 0,2). In conclusion, ECP and anticytokine therapy are equally effective in the treatment of children with steroid-refractory acute graft versus host disease and are associated with the same cumulative incidence of relapse.

scholarly journals Outcomes of Extracorporeal Photopheresis (ECP) in Treatment of Severe Acute Graft-Versus-Host Disease (aGvHD)

2021 ◽  
Vol 27 (3) ◽  
pp. S297-S298
Author(s):  
Zachary J Sebghati ◽  
Haitham Abdelhakim ◽  
Anurag K Singh ◽  
Leyla Shune ◽  
Siddhartha Ganguly ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Extracorporeal Photopheresis ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft
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