Impaired Notch signalling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa)

2013 ◽  
Vol 168 (4) ◽  
pp. 876-878 ◽  
Author(s):  
B.C. Melnik ◽  
G. Plewig
Keyword(s):  
Hidradenitis Suppurativa ◽  
Notch Signalling ◽  
Acne Inversa

Pathogenese der Hidradenitis suppurativa/Acne inversa

Der Hautarzt ◽  
2021 ◽  
Author(s):  
G. Nikolakis ◽  
G. Kokolakis ◽  
K. Kaleta ◽  
K. Wolk ◽  
R. Hunger ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Acne Inversa

3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Xiaoxiao Hou ◽  
Amir M. Hossini ◽  
Georgios Nikolakis ◽  
Ottfried Balthasar ◽  
Andreas Kurtz ◽  
...  
Keyword(s):  
Differential Expression ◽  
Hidradenitis Suppurativa ◽  
Structural Integrity ◽  
Ex Vivo ◽  
Human Model ◽  
Acne Inversa ◽  
Inflammatory Skin Disease ◽  
Preclinical Research ◽  
Dermal Tissue ◽  
Uninvolved Skin

<b><i>Background:</i></b> Hidradenitis suppurativa/acne inversa (HS) is a chronic, recurrent inflammatory skin disease. Its pivotal pathogenetic event is believed to be the occlusion of the hair follicle generating a perifollicular lympho-histiocytic inflammation. However, knowledge of the exact HS pathogenesis requires further research. <b><i>Objective:</i></b> To develop a human HS model applicable in preclinical research which could help to understand the pathophysiology of HS and to determine the action of therapeutic candidates. <b><i>Methods:</i></b> The 3D-SeboSkin technology was applied to maintain explants of involved and uninvolved skin of HS patients ex vivo for 3 days. Detection of differential expression of previously detected HS biomarkers was performed by immunohistochemistry in a group of female patients (<i>n</i> = 9, mean age 37.2 ± 8.4 years). <b><i>Results:</i></b> The application of the 3D-SeboSkin model preserved the structural integrity of lesional and perilesional HS skin ex vivo, as previously described for healthy skin. Moreover, the HS 3D-SeboSkin setting maintained the differential expression and pattern of several HS biomarkers (S100A9, KRT16, SERPINB3) in epidermal and dermal tissue and the appendages. <b><i>Conclusion:</i></b> We have validated HS 3D-SeboSkin as a reproducible, human model, which is appropriate for preclinical lesional and perilesional HS skin studies ex vivo.

scholarly journals Quality of Life in Hidradenitis Suppurativa: An Update

2021 ◽  
Vol 18 (11) ◽  
pp. 6131
Author(s):  
Pavel V. Chernyshov ◽  
Andrew Y. Finlay ◽  
Lucia Tomas-Aragones ◽  
Francoise Poot ◽  
Francesca Sampogna ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Hidradenitis Suppurativa ◽  
Acne Inversa ◽  
Health Related Quality ◽  
Number Of Patients ◽  
Related Quality ◽  
Health Related ◽  
Positive Effect ◽  
Specific Health

Knowledge on hidradenitis suppurativa/acne inversa (HS) is rapidly increasing. HS has a profound impact on patients and their family life. Several factors, such as comorbidities, unemployment and HS severity, make this impact even more severe. The most widely used instrument to measure this impact is the dermatology-specific DLQI. We also identified six HS-specific health-related quality of life (HRQoL) instruments. Of them, HIDRAdisk, HSIA, HiSQOL and HSQoL-24 are better validated but there is still lack of experience of its use. Several treatment methods showed positive effect on patients’ HRQoL. Surgery remains a method with a substantial positive effect on HRQoL. Several studies confirming a positive effect of adalimumab on the HRQoL of patients with HS were published during the last three years. Data on the influence of several other biologics on HRQoL of HS patients are controversial or based on studies with a small number of patients.

Hidradenitis suppurativa/Acne inversa

Der Hautarzt ◽  
2015 ◽  
Vol 66 (6) ◽  
pp. 413-422 ◽  
Author(s):  
J. Kirschke ◽  
S. Hessam ◽  
F.G. Bechara
Keyword(s):  
Hidradenitis Suppurativa ◽  
Acne Inversa

Retinoids in Hidradenitis Suppurativa/Acne Inversa

2019 ◽  
pp. 121-124
Author(s):  
Uwe Wollina ◽  
Piotr Brzezinski ◽  
André Koch
Keyword(s):  
Hidradenitis Suppurativa ◽  
Acne Inversa
Sign in / Sign up

Export Citation Format

Share Document