scholarly journals Estimation of the odds ratio in a proportional odds model with censored time‐lagged outcome in a randomized clinical trial

Biometrics ◽  
2021 ◽  
Author(s):  
Anastasios A. Tsiatis ◽  
Marie Davidian ◽  
Shannon T. Holloway
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Odds Ratio ◽  
Proportional Odds Model ◽  
Proportional Odds ◽  
Time Lagged

scholarly journals Proportional odds model for dose-finding clinical trial designs with ordinal toxicity grading

2011 ◽  
Vol 30 (17) ◽  
pp. 2070-2080 ◽  
Author(s):  
Emily M. Van Meter ◽  
Elizabeth Garrett-Mayer ◽  
Dipankar Bandyopadhyay
Keyword(s):  
Clinical Trial ◽  
Proportional Odds Model ◽  
Dose Finding ◽  
Proportional Odds ◽  
Clinical Trial Designs

Steroid Treatment of Laryngotracheitis: A Meta-Analysis of the Evidence From Randomized Trials

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 683-693 ◽  
Author(s):  
Steven W. Kairys ◽  
Elaine Marsh Olmstead ◽  
Gerald T. O'Connor
Keyword(s):  
Clinical Trial ◽  
Confidence Interval ◽  
Randomized Clinical Trial ◽  
Clinical Improvement ◽  
Endotracheal Intubation ◽  
Odds Ratio ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Steroid Treatment ◽  
Reliable Estimate

The use of adrenocorticoids to reduce the morbidity associated with laryngotracheitis (croup) remains controversial despite ten published reports of randomized trials involving 1,286 patients. To determine whether, viewed in aggregate, these studies demonstrate a significant benefit of steroid treatment for this disorder, a meta-analysis of the nine methodologically satisfactory trials was performed. Clinical improvement 12 and 24 hours posttreatment and incidence of endotracheal intubation were evaluated. For each end point, an estimate of the overall effect was obtained by calculating a typical odds ratio and 95% confidence interval. This analysis indicates that the use of steroids in children hospitalized with croup is associated with a significantly increased proportion of patients showing clinical improvement 12 hours (odds ratio = 2.25, 95% confidence interval = 1.66, 3.06) and 24 hours (odds ratio = 3.19, 95% confidence interval = 1.70, 5.99) posttreatment and a significantly reduced incidence of endotracheal intubation (odds ratio = 0.21, 95% confidence interval = 0.05, 0.84). Higher initial doses of steroid (≥125 mg of cortisone or ≥100 mg of hydrocortisone) were associated with a larger proportion of patients improved 12 hours posttreatment than was seen with lower doses. These results support the use of steroids in the treatment of hospitalized children with croup and, in the absence of a randomized clinical trial of sufficient size, provide the most reliable estimate of the impact of steroid therapy on the morbidity associated with croup. In addition, the results of this meta-analysis may be used to estimate the number of subjects who would be required to conduct a randomized clinical trial of steroids for the treatment of croup.

scholarly journals Penerapan Regresi Logistik Ordinal Proportional Odds Model pada Analisis Faktor-Faktor yang Mempengaruhi Kelengkapan Imunisasi Dasar Anak Balita di Provinsi Aceh Tahun 2015

2017 ◽  
Vol 10 (1) ◽  
pp. 37
Author(s):  
Budyanra Budyanra ◽  
Ghaida Nasria Azzahra
Keyword(s):  
Logistic Regression ◽  
Odds Ratio ◽  
Maternal Education ◽  
Immunization Coverage ◽  
Ordinal Logistic Regression ◽  
Proportional Odds Model ◽  
Proportional Odds ◽  
Number Of Children ◽  
Ordinal Logistic Regression Analysis ◽  
The Status

Province of Aceh has basic immunization coverage toddler lowest in Indonesia in 2015. even though, this province has Posyandu and Puskesmas ratio per population of the highest in the western region of Indonesia. This data their concerns regarding immunization coverage has not been handled well in Aceh Province. This papers aims to identify variables that affect the status of complete basic immunization of children aged 12-59 months in Aceh by using ordinal logistic regression analysis. Ordinal logistic regression model used is proportional odds models. Data are obtained from Susenas 2015 that was held in March 2015 by BPS-Statistic of Indonesia. Based on the results of processing data, known only 37.7% of children aged 12-59 months in the province of Aceh in 2015 which gets fully immunized, the remaining 50.6% receive primary immunization but is not complete, even about 11.7% have not received basic immunization at all. From the proportional odds model results showed that the number of children born to mothers (odds ratio = 0.88), maternal age at delivery (odds ratio = 1.03), the level of maternal education (odds ratio = 1.22), and the educational level of the household (odds ratio = 1,2) have a significant impact on the status of complete basic immunization of children. Future studies are expected to include the element of timeliness and add other variables and also with other models in ordinal logistic regression.Keywords:Immunization, Ordinal Logistic Regression, Proportional Odds, Susenas

Randomized clinical trial of LigasureTM versus open haemorrhoidectomy

2002 ◽  
Vol 89 (2) ◽  
pp. 154-157 ◽  
Author(s):  
F. F Palazzo ◽  
D. L Francis ◽  
M. A Clifton
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial
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