scholarly journals Estimating treatment importance in multidrug‐resistant tuberculosis using Targeted Learning: An observational individual patient data network meta‐analysis

Biometrics ◽  
2020 ◽  
Vol 76 (3) ◽  
pp. 1007-1016
Author(s):  
Guanbo Wang ◽  
Mireille E. Schnitzer ◽  
Dick Menzies ◽  
Piret Viiklepp ◽  
Timothy H. Holtz ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Meta Analysis ◽  
Multidrug Resistant ◽  
Patient Data ◽  
Data Network ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis

PLoS Medicine ◽  
2018 ◽  
Vol 15 (7) ◽  
pp. e1002591 ◽  
Author(s):  
Elizabeth P. Harausz ◽  
Anthony J. Garcia-Prats ◽  
Stephanie Law ◽  
H. Simon Schaaf ◽  
Tamara Kredo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Multidrug Resistant ◽  
Patient Data ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals Group 5 drugs for multidrug-resistant tuberculosis: individual patient data meta-analysis

2016 ◽  
Vol 49 (1) ◽  
pp. 1600993 ◽  
Author(s):  
Greg J. Fox ◽  
Andrea Benedetti ◽  
Helen Cox ◽  
Won-Jung Koh ◽  
Piret Viiklepp ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Meta Analysis ◽  
Treatment Success ◽  
Multidrug Resistant ◽  
Patient Data ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Amoxicillin Clavulanic Acid ◽  
Group 5

The role of so-called “group 5” second-line drugs as a part of antibiotic therapy for multidrug-resistant tuberculosis (MDR-TB) is widely debated. We performed an individual patient data meta-analysis to evaluate the effectiveness of several group 5 drugs including amoxicillin/clavulanic acid, thioacetazone, the macrolide antibiotics, linezolid, clofazimine and terizidone for treatment of patients with MDR-TB.Detailed individual patient data were obtained from 31 published cohort studies of MDR-TB therapy. Pooled treatment outcomes for each group 5 drug were calculated using a random effects meta-analysis. Primary analyses compared treatment success to a combined outcome of failure, relapse or death.Among 9282 included patients, 2191 received at least one group 5 drug. We found no improvement in treatment success among patients taking clofazimine, amoxicillin/clavulanic acid or macrolide antibiotics, despite applying a number of statistical approaches to control confounding. Thioacetazone was associated with increased treatment success (OR 2.6, 95% CI 1.1–6.1) when matched controls were selected from studies in which the group 5 drugs were not used at all, although this result was heavily influenced by a single study.The development of more effective antibiotics to treat drug-resistant TB remains an urgent priority.

scholarly journals Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis

The Lancet ◽  
2018 ◽  
Vol 392 (10150) ◽  
pp. 821-834 ◽  
Author(s):  
Nafees Ahmad ◽  
Shama D Ahuja ◽  
Onno W Akkerman ◽  
Jan-Willem C Alffenaar ◽  
Laura F Anderson ◽  
...  
Keyword(s):  
Individual Patient Data ◽  
Meta Analysis ◽  
Multidrug Resistant ◽  
Patient Data ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Successful Outcomes
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