scholarly journals A statistical method for joint estimation of cis ‐eQTLs and parent‐of‐origin effects under family trio design

Biometrics ◽  
2019 ◽  
Vol 75 (3) ◽  
pp. 864-874 ◽  
Author(s):  
Vasyl Zhabotynsky ◽  
Kaoru Inoue ◽  
Terry Magnuson ◽  
J. Mauro Calabrese ◽  
Wei Sun
Keyword(s):  
Statistical Method ◽  
Joint Estimation ◽  
Family Trio ◽  
Parent Of Origin ◽  
Origin Effects

Analysis of parent of origin effects in Sorbs using long range phasing algorithms

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
X Liu ◽  
M Scholz ◽  
A Tönjes ◽  
M Stumvoll ◽  
PF Stadler ◽  
...  
Keyword(s):  
Long Range ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-of-origin effects on voluntary exercise levels and body composition in mice

2010 ◽  
Vol 40 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Scott A. Kelly ◽  
Derrick L. Nehrenberg ◽  
Kunjie Hua ◽  
Ryan R. Gordon ◽  
Theodore Garland ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Wheel Running ◽  
Voluntary Exercise ◽  
Phenotypic Variance ◽  
In Utero Environment ◽  
Dependent Activity ◽  
Health Related ◽  
Parent Of Origin ◽  
Origin Effects

Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account for this individual variation. We created and phenotyped a large G4 advanced intercross line originating from reciprocal crosses between mice with genetic propensity for increased voluntary exercise (HR line) and the inbred strain C57BL/6J. G4 females (compared to males) ran significantly more when provided access to a running wheel and were smaller with a greater percentage of body fat pre- and postwheel access. Change in body composition resulting from a 6-day exposure to wheels varied between the sexes with females generally regulating energy balance more precisely in the presence of exercise. We observed parent-of-origin effects on most voluntary wheel running and body composition traits, which accounted for 3–13% of the total phenotypic variance pooled across sexes. G4 individuals descended from progenitor (F0) crosses of HR♀ and C57BL/6J♂ ran greater distances, spent more time running, ran at higher maximum speeds/day, and had lower percent body fat and higher percent lean mass than mice descended from reciprocal progenitor crosses (C57BL/6J♀ × HR♂). For some traits, significant interactions between parent of origin and sex were observed. We discuss these results in the context of sex dependent activity and weight loss patterns, the contribution of parent-of-origin effects to predisposition for voluntary exercise, and the genetic (i.e., X-linked or mtDNA variations), epigenetic (i.e., genomic imprinting), and environmental (i.e., in utero environment or maternal care) phenomena potentially modulating these effects.

scholarly journals Mutations in the FIE and MEA Genes That Encode Interacting Polycomb Proteins Cause Parent-of-Origin Effects on Seed Development by Distinct Mechanisms

2000 ◽  
Vol 12 (12) ◽  
pp. 2367-2381 ◽  
Author(s):  
Ramin Yadegari ◽  
Tetsu Kinoshita ◽  
Ofra Lotan ◽  
Gal Cohen ◽  
Anat Katz ◽  
...  
Keyword(s):  
Seed Development ◽  
Polycomb Proteins ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima Indians

Diabetes ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 2850-2857 ◽  
Author(s):  
R. S. Lindsay ◽  
S. Kobes ◽  
W. C. Knowler ◽  
P. H. Bennett ◽  
R. L. Hanson
Keyword(s):  
Type 2 Diabetes ◽  
Linkage Analysis ◽  
Pima Indians ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

Visualization of uniparental inheritance, Mendelian inconsistencies, deletions, and parent of origin effects in single nucleotide polymorphism trio data with SNPtrio

2007 ◽  
Vol 28 (12) ◽  
pp. 1225-1235 ◽  
Author(s):  
Jason C. Ting ◽  
Elisha D.O. Roberson ◽  
Nathaniel D. Miller ◽  
Alana Lysholm-Bernacchi ◽  
Dietrich A. Stephan ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Uniparental Inheritance ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-of-origin effects cause genetic variation in pig performance traits

animal ◽  
2010 ◽  
Vol 4 (5) ◽  
pp. 672-681 ◽  
Author(s):  
N. Neugebauer ◽  
H. Luther ◽  
N. Reinsch
Keyword(s):  
Genetic Variation ◽  
Performance Traits ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Pig Performance

scholarly journals Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12513 ◽  
Author(s):  
Delphine Fradin ◽  
Keely Cheslack-Postava ◽  
Christine Ladd-Acosta ◽  
Craig Newschaffer ◽  
Aravinda Chakravarti ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-of-Origin Effects on Glucose Homeostasis in Polycystic Ovary Syndrome

2014 ◽  
Vol 99 (8) ◽  
pp. 2961-2966 ◽  
Author(s):  
Kristen Kobaly ◽  
Priyathama Vellanki ◽  
Ryan K. Sisk ◽  
Loren Armstrong ◽  
Ji Young Lee ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Glucose Homeostasis ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jingli Zhao ◽  
Shuling Li ◽  
Lijuan Wang ◽  
Li Jiang ◽  
Runqing Yang ◽  
...  
Keyword(s):  
Body Composition ◽  
Regression Analysis ◽  
Random Regression ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects
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