scholarly journals A predictive enrichment procedure to identify potential responders to a new therapy for randomized, comparative controlled clinical studies

Biometrics ◽  
2015 ◽  
Vol 72 (3) ◽  
pp. 877-887 ◽  
Author(s):  
Junlong Li ◽  
Lihui Zhao ◽  
Lu Tian ◽  
Tianxi Cai ◽  
Brian Claggett ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Enrichment Procedure ◽  
New Therapy

scholarly journals New therapy options for patients with eosinophilic type of severe bronchial asthma

2020 ◽  
pp. 111-116
Author(s):  
G. L. Ignatova ◽  
V. N. Antonov ◽  
E. V. Blinova ◽  
I. V. Grebneva ◽  
E. V. Sheklanova
Keyword(s):  
Decision Making ◽  
Severe Asthma ◽  
Bronchial Asthma ◽  
Clinical Studies ◽  
Clinical Characteristics ◽  
Biological Therapy ◽  
Efficacy And Safety ◽  
Therapy Options ◽  
New Therapy ◽  
Chelyabinsk Region

The article provides data on the epidemiology of severe asthma. It defines the phenotype and endotype of bronchial asthma and classifies BA according to phenotype/endotype. The features of the eosinophilic phenotype of severe bronchial asthma are considered. Clinical characteristics of the patient corresponding to the prescription of benralizumab are presented. The algorithm of decision making by a doctor-therapist about patients’ referral to a pulmonologist for consideration of the biological therapy issue is given. The results of the main clinical studies to assess the efficacy and safety of benralizumab in patients with severe eosinophilic bronchial asthma: SIROCCO, CALIMA, ZONDA, BORA are described. The experience of using various biological preparations for the treatment of severe asthma in Chelyabinsk and the Chelyabinsk Region has also been summarized.

Clinical Studies in Human Strongyloidiasis

1950 ◽  
Vol 16 (4) ◽  
pp. 743-756 ◽  
Author(s):  
Charles A. Jones
Keyword(s):  
Clinical Studies

Exneriana – II – The Scientific Legacy of John E. Exner, Jr. 1Part of this paper was presented at the XIXth International Congress of Rorschach and Projective Methods, July 22–26, 2008, Louvain, Belgium.

2008 ◽  
Vol 29 (2) ◽  
pp. 81-107 ◽  
Author(s):  
Anne Andronikof
Keyword(s):  
Clinical Studies ◽  
Experimental Studies ◽  
Scientific Work ◽  
International Congress ◽  
Response Process ◽  
Scientific Legacy ◽  
Projective Test ◽  
Projective Methods ◽  
Comprehensive Picture ◽  
Complex Mechanisms

Based on an analysis of John Exner’s peer-reviewed published work from 1959 to 2007, plus a brief comment for an editorial in Rorschachiana, the author draws a comprehensive picture of the scientific work of this outstanding personality. The article is divided into three sections: (1) the experimental studies on the Rorschach, (2) the clinical studies using the Rorschach, and (3) Exner’s “testament,” which we draw from the last paper he saw published before his death (Exner, 2001/2002). The experimental studies were aimed at better understanding the nature of the test, in particular the respective roles of perception and projection in the response process. These fundamental studies led to a deeper understanding of the complex mechanisms involved in the Rorschach responses and introduced some hypotheses about the intentions of the author of the test. The latter were subsequently confirmed by the preparatory sketches and documents of Hermann Rorschach, which today can be seen at the H. Rorschach Archives and Museum in Bern (Switzerland). Exner’s research has evidenced the notion that the Rorschach is a perceptive-cognitive-projective test.

Sign in / Sign up

Export Citation Format

Share Document