scholarly journals Multivariate sparse group lasso for the multivariate multiple linear regression with an arbitrary group structure

Biometrics ◽  
2015 ◽  
Vol 71 (2) ◽  
pp. 354-363 ◽  
Author(s):  
Yanming Li ◽  
Bin Nan ◽  
Ji Zhu
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Jan Klosa ◽  
Noah Simon ◽  
Pål Olof Westermark ◽  
Volkmar Liebscher ◽  
Dörte Wittenburg

Abstract Background Statistical analyses of biological problems in life sciences often lead to high-dimensional linear models. To solve the corresponding system of equations, penalization approaches are often the methods of choice. They are especially useful in case of multicollinearity, which appears if the number of explanatory variables exceeds the number of observations or for some biological reason. Then, the model goodness of fit is penalized by some suitable function of interest. Prominent examples are the lasso, group lasso and sparse-group lasso. Here, we offer a fast and numerically cheap implementation of these operators via proximal gradient descent. The grid search for the penalty parameter is realized by warm starts. The step size between consecutive iterations is determined with backtracking line search. Finally, seagull -the R package presented here- produces complete regularization paths. Results Publicly available high-dimensional methylation data are used to compare seagull to the established R package SGL. The results of both packages enabled a precise prediction of biological age from DNA methylation status. But even though the results of seagull and SGL were very similar (R2 > 0.99), seagull computed the solution in a fraction of the time needed by SGL. Additionally, seagull enables the incorporation of weights for each penalized feature. Conclusions The following operators for linear regression models are available in seagull: lasso, group lasso, sparse-group lasso and Integrative LASSO with Penalty Factors (IPF-lasso). Thus, seagull is a convenient envelope of lasso variants.


2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Lei Wang ◽  
Juntao Li ◽  
Juanfang Liu ◽  
Mingming Chang

In view of the challenges of the group Lasso penalty methods for multicancer microarray data analysis, e.g., dividing genes into groups in advance and biological interpretability, we propose a robust adaptive multinomial regression with sparse group Lasso penalty (RAMRSGL) model. By adopting the overlapping clustering strategy, affinity propagation clustering is employed to obtain each cancer gene subtype, which explores the group structure of each cancer subtype and merges the groups of all subtypes. In addition, the data-driven weights based on noise are added to the sparse group Lasso penalty, combining with the multinomial log-likelihood function to perform multiclassification and adaptive group gene selection simultaneously. The experimental results on acute leukemia data verify the effectiveness of the proposed method.


2020 ◽  
Vol 2020 ◽  
pp. 1-23
Author(s):  
Xiaoli Liu ◽  
Jianzhong Wang ◽  
Fulong Ren ◽  
Jun Kong

As the largest cause of dementia, Alzheimer’s disease (AD) has brought serious burdens to patients and their families, mostly in the financial, psychological, and emotional aspects. In order to assess the progression of AD and develop new treatment methods for the disease, it is essential to infer the trajectories of patients’ cognitive performance over time to identify biomarkers that connect the patterns of brain atrophy and AD progression. In this article, a structured regularized regression approach termed group guided fused Laplacian sparse group Lasso (GFL-SGL) is proposed to infer disease progression by considering multiple prediction of the same cognitive scores at different time points (longitudinal analysis). The proposed GFL-SGL simultaneously exploits the interrelated structures within the MRI features and among the tasks with sparse group Lasso (SGL) norm and presents a novel group guided fused Laplacian (GFL) regularization. This combination effectively incorporates both the relatedness among multiple longitudinal time points with a general weighted (undirected) dependency graphs and useful inherent group structure in features. Furthermore, an alternating direction method of multipliers- (ADMM-) based algorithm is also derived to optimize the nonsmooth objective function of the proposed approach. Experiments on the dataset from Alzheimer’s Disease Neuroimaging Initiative (ADNI) show that the proposed GFL-SGL outperformed some other state-of-the-art algorithms and effectively fused the multimodality data. The compact sets of cognition-relevant imaging biomarkers identified by our approach are consistent with the results of clinical studies.


2017 ◽  
Vol 23 (2) ◽  
pp. 121-137
Author(s):  
Ary Sutrischastini ◽  
Agus Riyanto

This paper will discuss the effect of work motivation (incentives, motives and expectations) on the performance of the staff of the Regional Secretariat Gunungkidul. The purpose of this paper is: 1) Determine the effect of incentives on the performance of the staff of the Regional Secretariat Gunungkidul, 2) Determine the effect of motive on the performance of the staff of the Regional Secretariat Gunungkidul, 3) To know the effect of expectations on the performance of the staff of the Regional Secretariat Gunungkidul, 4)To know the effect of incentives, motives and expectations on the performance of the staff of the Regional Secretariat Gunungkidul.Research sites in the Regional Secretariat Gunungkidul and the population is 162entire employee in the Regional Secretariat Gunungkidul. Samples amounted to 116 respondents taken with simple random probability sampling method. Data were analyzed using multiple linear regression. Results obtained: (1) incentives positive and significant effect on the performance of, (2) motif positive and significant effect on the performance of, (3) expectations positive and significant impact on the performance of , and (4) incentives, motives and expectations of positive and significant impact on the performance of the staff of the Regional Secretariat Gunungkidul.


Author(s):  
Eka Ambara Harci Putranta ◽  
Lilik Ambarwati

The study aims to analyze the influence of internal banking factors in the form of: Capital Adequency Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing at Sharia Banks. This research method used multiple linear regression analysis with the help of SPSS 16.00 software which is used to see the influence between the independent variables in the form of Capital Adequacy Ratio (CAR), Financing to Deposit Ratio (FDR) and Total Assets (TA) to Non Performing Financing. The sample of this study was 3 Islamic Commercial Banks, so there were 36 annual reports obtained through purposive sampling, then analyzed using multiple linear regression methods. The results showed that based on the F Test, the independent variable had an effect on the NPF, indicated by the F value of 17,016 and significance of 0,000, overall the independent variable was able to explain the effect of 69.60%. While based on the partial t test, showed that CAR has a significant negative effect, Total assets have a significant positive effect with a significance value below 0.05 (5%). Meanwhile FDR does not affect NPF.


Author(s):  
Evi Mariana

The purpose of this study was to analyze the factors that influence the decisionof the students chose to study in Obstetrics Prodi STIKES Muhammadiyah Ciamis and analyze the factors that most influence the decision of the students chose to study in Obstetrics Prodi STIKES Muhammadiyah Ciamis. Collecting data in this study was conducted using a survey by questionnaire to 114 students by stratified random sampling method. Methods of data analysis using multiple linear regression, F test and test T. The result is a marketing mix that significantly is the product, place, and physical evidence. And that does not affect the marketing mix is price, promotion, place, and processes


Author(s):  
Muhammad Rois Rois ◽  
Manarotul Fatati Fatati ◽  
Winda Ihda Magfiroh

This study aims to determine the effect of Inflation, Exchange Rate and Composite Stock Price Index (IHSG) to Return of PT Nikko Securities Indonesia Stock Fund period 2014-2017. The study used secondary data obtained through documentation in the form of PT Nikko Securities Indonesia Monthly Net Asset (NAB) report. Data analysis is used with quantitative analysis, multiple linear regression analysis using eviews 9. Population and sample in this research are PT Nikko Securities Indonesia. The result of multiple linear regression analysis was the coefficient of determination (R2) showed the result of 0.123819 or 12%. This means that the Inflation, Exchange Rate and Composite Stock Price Index (IHSG) variables can influence the return of PT Nikko Securities Indonesia's equity fund of 12% and 88% is influenced by other variables. Based on the result of the research, the variables of inflation and exchange rate have a negative and significant effect toward the return of PT Nikko Securities Indonesia's equity fund. While the variable of Composite Stock Price Index (IHSG) has a negative but not significant effect toward Return of Equity Fund of PT Nikko Securities Indonesia


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