Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Clare Cullen ◽  
Nils Kappelmann ◽  
Madeha Umer ◽  
Ali Abdolizadeh ◽  
M. Omair Husain ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Comorbid Anxiety

Group Psychoeducation for Anxiety Symptoms in Youth: Systematic Review and Meta-analysis

2021 ◽  
pp. 1-21
Author(s):  
Vasiliki C. Baourda ◽  
Andreas Brouzos ◽  
Dimitris Mavridis ◽  
Stephanos P. Vassilopoulos ◽  
Effrosyni Vatkali ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Group Psychoeducation

Clozapine in bipolar disorder: A systematic review and meta-analysis

2020 ◽  
Vol 125 ◽  
pp. 21-27 ◽  
Author(s):  
Andre Delgado ◽  
Jorge Velosa ◽  
Junyu Zhang ◽  
Serdar M. Dursun ◽  
Flavio Kapczinski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Meta Analysis

scholarly journals Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Maximilian Pilhatsch ◽  
Thomas J Stamm ◽  
Petra Stahl ◽  
Ute Lewitzka ◽  
Anne Berghöfer ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Rating Scale ◽  
Bipolar Depression ◽  
Phenotypic Expression ◽  
Anxiety Symptoms ◽  
Controlled Study ◽  
Double Blind ◽  
Comorbid Anxiety ◽  
Depressed Patients ◽  
Depressive Episodes

Abstract Background Symptoms of anxiety co-occur in a variety of disorders including in depressive episodes of bipolar disorder and in patients with thyrotoxicosis. Treatment of refractory bipolar disorder with supraphysiologic doses of levothyroxine (L-T4) has been shown to improve the phenotypic expression of the disorder and is associated with an increase of circulating thyroid hormones. However, it might be associated with somatic and mental adverse effects. Here we report the investigation of the influence of treatment with supraphysiologic doses of L-T4 on symptoms of anxiety in patients with refractory bipolar depression. Methods Post-hoc analysis from a 6-week, multi-center, randomized, double-blind, placebo-controlled study of the effects of supraphysiologic L-T4 treatment on anxiety symptoms in bipolar depression. Anxiety symptoms were measured weekly with the Hamilton anxiety/somatization factor (HASF) score of the Hamilton Depression Rating Scale (HAMD) and the State- and Trait Anxiety Inventory (STAI). Results Treatment of both groups was associated with a significant reduction in anxiety symptoms (p < 0.001) with no statistical difference between groups (LT-4: from 5.9 (SD = 2.0) at baseline to 3.7 (SD = 2.4) at study end; placebo: from 6.1 (SD = 2.4) at baseline to 4.4 (SD = 2.8) at study end; p = 0.717). Severity of anxiety at baseline did not show a statistically significant correlation to the antidepressive effect of treatment with supraphysiologic doses of L-T4 (p = 0.811). Gender did not show an influence on the reduction of anxiety symptoms (females: from 5.6 (SD = 1.7) at baseline to 3.5 (SD = 2.4) at study end; males: from 6.1 (SD = 2.3) at baseline to 4.0 (SD = 2.4) at study end; p = 0.877). Conclusions This study failed to detect a difference in change of anxiety between bipolar depressed patients treated with supraphysiologic doses of L-T4 or placebo. Comorbid anxiety symptoms should not be considered a limitation for the administration of supraphysiologic doses of L-T4 refractory bipolar depressed patients. Trial registration ClinicalTrials, ClinicalTrials.gov identifier: NCT01528839. Registered 2 June 2012—Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT01528839

scholarly journals Violent criminal behavior in the context of bipolar disorder: Systematic review and meta-analysis

2018 ◽  
Vol 239 ◽  
pp. 161-170 ◽  
Author(s):  
Norma Verdolini ◽  
Isabella Pacchiarotti ◽  
Cristiano A. Köhler ◽  
Maria Reinares ◽  
Ludovic Samalin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Criminal Behavior ◽  
Meta Analysis ◽  
Violent Criminal

Efficacy of omega-3 supplementation on sertraline continuous therapy to reduce depression or anxiety symptoms: A systematic review and meta-analysis

2021 ◽  
Vol 296 ◽  
pp. 113652
Author(s):  
Diego Chambergo-Michilot ◽  
Ana Brañez-Condorena ◽  
Ian Falvy-Bockos ◽  
Josmel Pacheco-Mendoza ◽  
Vicente A. Benites-Zapata
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Omega 3 ◽  
Continuous Therapy
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