scholarly journals Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep-related differences in fronto-limbic activation patterns

2018 ◽  
Vol 20 (3) ◽  
pp. 238-247 ◽  
Author(s):  
Adriane M Soehner ◽  
Tina R Goldstein ◽  
Sarah M Gratzmiller ◽  
Mary L Phillips ◽  
Peter L Franzen
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Control ◽  
Transitional Age Youth ◽  
Activation Patterns ◽  
Transitional Age

scholarly journals A Fundamental Distinction in Early Neural Processing of Implicit Social Interpretation in Schizophrenia and Bipolar Disorder

2021 ◽  
Author(s):  
Nuno Gonçalo Gomes Fernandes Madeira ◽  
Ricardo Filipe Alves Martins ◽  
João Valente Duarte ◽  
Gabriel Nascimento Ferreira Costa ◽  
António João Ferreira Macedo Santos ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Social Cognitive ◽  
Characteristic Curve ◽  
Superior Temporal Gyrus ◽  
Neural Responses ◽  
Opposite Pattern ◽  
Activation Patterns ◽  
Temporoparietal Junction ◽  
Distinctive Features ◽  
The Right

ABSTRACTBackgroundSocial cognition impairment is a key phenomenon in serious mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). Although genetic and neurobiological studies have suggested common neural correlates, here we hypothesized that a fundamental dissociation of social processing occurs at an early level in these conditions.MethodsBased on the hypothesis that key structures in the social brain, namely the temporoparietal junction, should present distinctive features in SCZ and BPD during low-level social judgment, we conducted a case-control study in SCZ (n=20) and BPD (n=20) patients and controls (n=20), using task-based fMRI during a Theory-of-Mind (ToM) visual paradigm leading to interpretation of social meaning based on simple geometric figures.ResultsWe found opposite neural responses in two core ToM regions : SCZ patients showed social content-related deactivation (relative to controls and BPD) of the right supramarginal gyrus, a region which activity is required to overcome egocentric “overmentalizing”, while the opposite pattern was found in BPD; reverse patterns, relative to controls and SCZ, were found in the left posterior superior temporal gyrus, a region involved in inferring other’s intentions. Receiver-operating-characteristic curve analysis showed 88% accuracy in discriminating the two clinical groups based on these neural responses.ConclusionsThese contrasting activation patterns of the temporoparietal junction in SCZ and BPD represent mechanistic differences of social cognitive dysfunction that may be explored as biomarkers or therapeutic targets.

532. Multimodal MRI Analysis of Medial Prefrontal Cortex and Cognitive Control in Adolescent Bipolar Disorder

2017 ◽  
Vol 81 (10) ◽  
pp. S215-S216
Author(s):  
Arron W.S. Metcalfe ◽  
Bradley J. MacIntosh ◽  
Alvi H. Islam ◽  
Henri J.M.M. Mutsaerts ◽  
Daphne Korczak ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Prefrontal Cortex ◽  
Cognitive Control ◽  
Medial Prefrontal Cortex ◽  
Multimodal Mri
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