scholarly journals Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta-analyses

2017 ◽  
Vol 19 (2) ◽  
pp. 84-96 ◽  
Author(s):  
Beatrice Bortolato ◽  
Cristiano A. Köhler ◽  
Evangelos Evangelou ◽  
Jordi León-Caballero ◽  
Marco Solmi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Systematic Reviews ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Umbrella Review ◽  
Systematic Assessment ◽  
Meta Analyses

Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses

2017 ◽  
Vol 13 (4) ◽  
pp. 406-418 ◽  
Author(s):  
Vanesa Bellou ◽  
Lazaros Belbasis ◽  
Ioanna Tzoulaki ◽  
Lefkos T. Middleton ◽  
John P.A. Ioannidis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Reviews ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Systematic Evaluation ◽  
Umbrella Review ◽  
Meta Analyses

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

2015 ◽  
Vol 14 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Lazaros Belbasis ◽  
Vanesa Bellou ◽  
Evangelos Evangelou ◽  
John P A Ioannidis ◽  
Ioanna Tzoulaki
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Systematic Reviews ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Umbrella Review ◽  
Meta Analyses

scholarly journals Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses

2016 ◽  
Vol 23 ◽  
pp. 1-9 ◽  
Author(s):  
Vanesa Bellou ◽  
Lazaros Belbasis ◽  
Ioanna Tzoulaki ◽  
Evangelos Evangelou ◽  
John P.A. Ioannidis
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Umbrella Review ◽  
Meta Analyses

scholarly journals Environmental Risk Factors and Amyotrophic Lateral Sclerosis: An Umbrella Review and Critical Assessment of Current Evidence from Systematic Reviews and Meta-Analyses of Observational Studies

2016 ◽  
Vol 46 (2) ◽  
pp. 96-105 ◽  
Author(s):  
Lazaros Belbasis ◽  
Vanesa Bellou ◽  
Evangelos Evangelou
Keyword(s):  
Risk Factors ◽  
Amyotrophic Lateral Sclerosis ◽  
Environmental Factors ◽  
Random Effects ◽  
Systematic Reviews ◽  
Environmental Risk ◽  
Observational Studies ◽  
Environmental Risk Factors ◽  
Meta Analyses ◽  
Lateral Sclerosis

Background: The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both environmental and genetic factors. Our study aimed at summarising the environmental risk factors for ALS, assessing the evidence for diverse biases, and pinpointing risk factors with high epidemiological credibility. Methods: We searched PubMed from inception to August 20, 2015, to identify systematic reviews and meta-analyses of observational studies examining associations between environmental factors and ALS. For each meta-analysis, we estimated the summary effect size by the use of random-effects and fixed-effects models, the 95% CI, the 95% prediction interval (PI), and the between-study heterogeneity. We assessed the evidence of small-study effects and excess significance bias. Results: Sixteen unique meta-analyses of different risk factors and ALS were considered. Of them, 5 were statistically significant at p < 0.001 under the random-effects model. Only one factor presented robust evidence for a convincing association. This association pertained to chronic occupational exposure to lead (random-effects OR 1.81, 95% CI 1.39-2.35). Conclusions: A small number of published meta-analyses on environmental factors and risk of ALS was identified, a phenomenon that could be attributed to the challenges in studying a rare neurological disease. More observational studies with adequate sample size and study design are needed to clarify the environmental component of ALS pathogenesis.

scholarly journals Environmental Risk Factors and Health: An Umbrella Review of Meta-Analyses

2021 ◽  
Vol 18 (2) ◽  
pp. 704
Author(s):  
David Rojas-Rueda ◽  
Emily Morales-Zamora ◽  
Wael Abdullah Alsufyani ◽  
Christopher H. Herbst ◽  
Salem M. AlBalawi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Air Pollution ◽  
Environmental Risk ◽  
Tobacco Smoke ◽  
Environmental Exposures ◽  
Case Control ◽  
Environmental Risk Factors ◽  
Umbrella Review ◽  
Case Crossover ◽  
Meta Analyses

Background: Environmental health is a growing area of knowledge, continually increasing and updating the body of evidence linking the environment to human health. Aim: This study summarizes the epidemiological evidence on environmental risk factors from meta-analyses through an umbrella review. Methods: An umbrella review was conducted on meta-analyses of cohort, case-control, case-crossover, and time-series studies that evaluated the associations between environmental risk factors and health outcomes defined as incidence, prevalence, and mortality. The specific search strategy was designed in PubMed using free text and Medical Subject Headings (MeSH) terms related to risk factors, environment, health outcomes, observational studies, and meta-analysis. The search was limited to English, Spanish, and French published articles and studies on humans. The search was conducted on September 20, 2020. Risk factors were defined as any attribute, characteristic, or exposure of an individual that increases the likelihood of developing a disease or death. The environment was defined as the external elements and conditions that surround, influence, and affect a human organism or population’s life and development. The environment definition included the physical environment such as nature, built environment, or pollution, but not the social environment. We excluded occupational exposures, microorganisms, water, sanitation and hygiene (WASH), behavioral risk factors, and no-natural disasters. Results: This umbrella review found 197 associations among 69 environmental exposures and 83 diseases and death causes reported in 103 publications. The environmental factors found in this review were air pollution, environmental tobacco smoke, heavy metals, chemicals, ambient temperature, noise, radiation, and urban residential surroundings. Among these, we identified 65 environmental exposures defined as risk factors and 4 environmental protective factors. In terms of study design, 57 included cohort and/or case-control studies, and 46 included time-series and/or case-crossover studies. In terms of the study population, 21 included children, and the rest included adult population and both sexes. In this review, the largest body of evidence was found in air pollution (91 associations among 14 air pollution definitions and 34 diseases and mortality diagnoses), followed by environmental tobacco smoke with 24 associations. Chemicals (including pesticides) were the third larger group of environmental exposures found among the meta-analyses included, with 19 associations. Conclusion: Environmental exposures are an important health determinant. This review provides an overview of an evolving research area and should be used as a complementary tool to understand the connections between the environment and human health. The evidence presented by this review should help to design public health interventions and the implementation of health in all policies approach aiming to improve populational health.

scholarly journals Environmental Risk Factors for Inflammatory Bowel Diseases: An Umbrella Review of Meta-analyses

2019 ◽  
Vol 157 (3) ◽  
pp. 647-659.e4 ◽  
Author(s):  
Daniele Piovani ◽  
Silvio Danese ◽  
Laurent Peyrin-Biroulet ◽  
Georgios K. Nikolopoulos ◽  
Theodore Lytras ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Inflammatory Bowel Diseases ◽  
Environmental Risk Factors ◽  
Umbrella Review ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Meta Analyses
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