The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is associated with increased body mass index and insulin resistance measures in bipolar disorder and schizophrenia

2015 ◽  
Vol 17 (5) ◽  
pp. 528-535 ◽  
Author(s):  
Stefania Bonaccorso ◽  
Monsheel Sodhi ◽  
Jiang Li ◽  
William V Bobo ◽  
Yuejin Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Bipolar Disorder ◽  
Body Mass ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism ◽  
The Brain

scholarly journals Cerebral 5-HT2A Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

2010 ◽  
Vol 30 (11) ◽  
pp. e1-e7 ◽  
Author(s):  
Anders Bue Klein ◽  
Viktorija Trajkovska ◽  
David Erritzoe ◽  
Steven Haugbol ◽  
Jacob Madsen ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Receptor Binding ◽  
Neurotrophic Factor ◽  
Healthy Subjects ◽  
Brain Derived Neurotrophic Factor ◽  
Serotonergic System ◽  
Val66met Polymorphism ◽  
Serotonin System ◽  
Bdnf Val66met Polymorphism ◽  
The Brain

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT2A) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT2A receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT2A receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT2A or SERT binding.

scholarly journals Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

2009 ◽  
Vol 31 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Juliana Fernandes Tramontina ◽  
Denise Yates ◽  
Pedro Vieira da Silva Magalhães ◽  
Clarissa Trentini ◽  
Márcia Kauer Sant'Anna ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
Wisconsin Card Sorting ◽  
Sorting Test ◽  
The Brain

OBJECTIVE: In the present study, we investigate the association between the val66met polymorphism of the brain-derived neurotrophic factor (BNDF) and the performance on the Wisconsin Card Sorting Test in a sample of Caucasian Brazilian patients with bipolar disorder. METHOD: Sixty-four patients with bipolar disorder were assessed and their performance on the Wisconsin Card Sorting Test was compared with the allele frequency and genotype of the val66met polymorphism of the brain-derived neurotrophic factor. RESULTS: The percentage of non-perseverative errors was significantly higher among patients with the val/val genotype. There was no association between (BNDF) genotype frequency and other Wisconsin Card Sorting Test domains. CONCLUSION: Our results did not replicate previous descriptions of an association between a worse cognitive performance and the presence of the met allele of the val66met brain-derived neurotrophic factor gene polymorphism.

scholarly journals Bipolar Disorder, Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism and Brain Morphology

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e38469 ◽  
Author(s):  
Cheryl Ann Teh ◽  
Tih-Shih Lee ◽  
Margaratha Kuchibhatla ◽  
Allison Ashley-Koch ◽  
James MacFall ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Brain Morphology ◽  
Val66met Polymorphism ◽  
Bdnf Val66met Polymorphism
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