scholarly journals High anticholinergic burden at admission associated with in‐hospital mortality in older patients: A comparison of 19 different anticholinergic burden scales

2021 ◽  
Author(s):  
Angela Lisibach ◽  
Giulia Gallucci ◽  
Patrick E. Beeler ◽  
Chantal Csajka ◽  
Monika Lutters
Keyword(s):  
Hospital Mortality ◽  
Older Patients ◽  
Anticholinergic Burden

scholarly journals Does chronic oral anticoagulation reduce in-hospital mortality among COVID-19 older patients?

2021 ◽  
Author(s):  
Marcello Covino ◽  
Giuseppe De Matteis ◽  
Davide Della Polla ◽  
Maria Livia Burzo ◽  
Marco Maria Pascale ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Oral Anticoagulation ◽  
Older Patients

scholarly journals Reply to: Comment on Predicting In‐Hospital Mortality in COVID ‐19 Older Patients with Specifically Developed Scores

2021 ◽  
Author(s):  
Marcello Covino ◽  
Giuseppe De Matteis ◽  
Maria Livia Burzo ◽  
Francesco Franceschi ◽  
Claudio Sandroni
Keyword(s):  
Hospital Mortality ◽  
Older Patients

scholarly journals 119 * TOTAL ANTICHOLINERGIC BURDEN (ACB) AND IN-PATIENT HOSPITAL MORTALITY AND LENGTH OF STAY IN PATIENTS AGED>= 90 YEARS ADMITTED WITH AN ACUTE ILLNESS

2014 ◽  
Vol 43 (suppl 1) ◽  
pp. i33-i33
Author(s):  
A. C. Kidd ◽  
P. Musonda ◽  
R. L. Soiza ◽  
C. Butchart ◽  
C. J. Lunt ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Hospital Mortality ◽  
Acute Illness ◽  
Anticholinergic Burden

A comparison of anticholinergic burden in older patients with and without cancer

2021 ◽  
Author(s):  
Ayse Irem Yasin ◽  
Atakan Topcu ◽  
Meysere Nur Akuc ◽  
Hacı Mehmet Türk ◽  
Pinar Soysal
Keyword(s):  
Older Patients ◽  
Nutritional Assessment ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Mini Nutritional Assessment ◽  
Patients With Cancer ◽  
Cancer Management ◽  
Rational Drug ◽  
Geriatric Clinic ◽  
Anticholinergic Burden

Aim: To compare anticholinergic burden (ACB) in older patients with and without cancer and evaluate the effects of ACB on geriatric syndromes. Methods: A total of 291 patients from the geriatric clinic and 301 patients from the oncology clinic were evaluated. ACB <2 was categorized as low ACB and ACB ≥2 was categorized as high ACB. A comprehensive geriatric assessment was performed on patients from the geriatric clinic. Results: ACB scores were significantly higher in patients without cancer compared with those with cancer (p < 0.005). Number of falls and Geriatric Depression Scale 15 scores were higher and Mini-Nutritional Assessment and Barthel/Lawton activities of daily living scores were lower in geriatric patients with high ACB scores compared with those with low ACB scores (p < 0.005). Conclusion: It is crucial to understand the potential effects of ACB for rational drug use and optimum cancer management in older patients with cancer.

scholarly journals Emergency laparotomy in the older patient: factors predictive of 12-month mortality—Salford-POPS-GS. An observational study

2020 ◽  
Vol 32 (11) ◽  
pp. 2367-2373 ◽  
Author(s):  
Arturo Vilches-Moraga ◽  
Mollie Rowley ◽  
Jenny Fox ◽  
Haroon Khan ◽  
Areej Paracha ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Observational Study ◽  
Hospital Mortality ◽  
Older Patients ◽  
Care Home ◽  
Emergency Laparotomy ◽  
Older Patient ◽  
Readmission Rates ◽  
Clinical Frailty Scale ◽  
Female Predominance

Abstract Introduction Although high rates of in-hospital mortality have been described in older patients undergoing emergency laparotomy (EL), less is known about longer-term outcomes in this population. We describe factors present at the time of hospital admission that influence 12-month survival in older patients. Methods Observational study of patients aged 75 years and over, who underwent EL at our hospital between 8th September 2014 and 30th March 2017. Results 113 patients were included. Average age was 81.9 ± 4.7 years, female predominance (60/113), 3 (2.6%) lived in a care home, 103 (91.2%) and 79 (69.1%) were independent of personal and instrumental activities of daily living (ADLs) and 8 (7.1%) had cognitive impairment. Median length of stay was 16 days ± 29.9 (0–269); in-hospital mortality 22.1% (25/113), post-operative 30-day, 90-day and 12-month mortality rates 19.5% (22), 24.8% (28) and 38.9% (44). 30-day and 12-month readmission rates 5.7% (5/88) and 40.9% (36). 12-month readmission was higher in frail patients, using the Clinical Frailty Scale (CFS) score (64% 5–8 vs 31.7% 1–4, p = 0.006). Dependency for personal ADLs (6/10 (60%) dependent vs. 38/103 (36.8%) independent, p = 0.119) and cognitive impairment (5/8 (62.5%) impaired vs. 39/105 (37.1%) no impairment, p = 0.116) showed a trend towards higher 12-month mortality. On multivariate analysis, 12-month mortality was strongly associated with CFS 5–9 (HR 5.0403 (95% CI 1.719–16.982) and ASA classes III–V (HR 2.704 95% CI 1.032–7.081). Conclusion Frailty and high ASA class predict increased mortality at 12 months after emergency laparotomy. We advocate early engagement of multi-professional teams experienced in perioperative care of older patients.

Size of the associations between anticholinergic burden tool scores and adverse outcomes in older patients

2020 ◽  
Author(s):  
Marta Lavrador ◽  
Ana C. Cabral ◽  
Isabel V. Figueiredo ◽  
Manuel T. Veríssimo ◽  
M. Margarida Castel-Branco ◽  
...  
Keyword(s):  
Older Patients ◽  
Adverse Outcomes ◽  
Anticholinergic Burden

scholarly journals In-hospital mortality among incident hemodialysis older patients in Peru

2019 ◽  
Vol 12 (2) ◽  
pp. 142-147
Author(s):  
Percy Herrera-Añazco ◽  
Pedro J Ortiz ◽  
Jesus E Peinado ◽  
Tania Tello ◽  
Fabiola Valero ◽  
...  
Keyword(s):  
Hospital Mortality ◽  
Older Patients ◽  
Linear Models ◽  
Venous Catheter ◽  
Ageing Population ◽  
Middle Income ◽  
Middle Income Countries ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Understanding the pattern of mortality linked to end stage renal disease (ESRD) is important given the increasing ageing population in low- and middle-income countries. Methods We analyzed older patients with ESRD with incident hemodialysis, from January 2012 to August 2017 in one large general hospital in Peru. Individual and health system-related variables were analyzed using Generalized Linear Models (GLM) to estimate their association with in-hospital all-cause mortality. Relative risk (RR) with their 95% confidence intervals (95% CI) were calculated. Results We evaluated 312 patients; mean age 69 years, 93.6% started hemodialysis with a transient central venous catheter, 1.7% had previous hemodialysis indication and 24.7% died during hospital stay. The mean length of stay was 16.1 days (SD 13.5). In the adjusted multivariate models, we found higher in-hospital mortality among those with encephalopathy (aRR 1.85, 95% CI 1.21-2.82 vs. without encephalopathy) and a lower in-hospital mortality among those with eGFR ≤7 mL/min (aRR 0.45, 95% CI 0.31-0.67 vs. eGFR&gt;7 mL/min). Conclusions There is a high in-hospital mortality among older hemodialysis patients in Peru. The presence of uremic encephalopathy was associated with higher mortality and a lower estimated glomerular filtration rate with lower mortality.

Safety of microvascular decompression for trigeminal neuralgia in the elderly

2011 ◽  
Vol 115 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Anand I. Rughani ◽  
Travis M. Dumont ◽  
Chih-Ta Lin ◽  
Bruce I. Tranmer ◽  
Michael A. Horgan
Keyword(s):  
Mortality Rate ◽  
Hospital Mortality ◽  
Microvascular Decompression ◽  
Older Patients ◽  
The Elderly ◽  
Hospital Charges ◽  
National Database ◽  
Wound Complications ◽  
Total Hospital ◽  
Large National Database

Object Microvascular decompression (MVD) offers an effective and durable treatment for patients suffering from trigeminal neuralgia (TN). Because the disorder has a tendency to occur in older persons, the risks of surgical treatment in the elderly have been a topic of recent interest. To date, evidence derived from several small retrospective and a single prospective case series has suggested that age does not increase the complication rate associated with surgery. Using a large national database, the authors aimed to study the impact of age on in-hospital complications following MVD for TN. Methods Using the Nationwide Inpatient Sample (NIS) for the 10-year period from 1999 to 2008, the authors selected all patients who underwent MVD for TN. The primary outcome of interest was the in-hospital mortality rate. Secondary outcomes of interest were cardiac, pulmonary, thromboembolic, cerebrovascular, and wound complications as well as the duration of hospital stay, total hospital charges, and discharge location. An elderly cohort of patients was first defined as those 65 years of age and older and then redefined as those 75 years and older. Results A total of 3273 patients who underwent MVD for TN were identified, having a median age of 57 years. Within this sample, 31.5% were 65 years and older and 10.7% were 75 years and older. The in-hospital mortality rate was 0.68% for patients 65 years or older (p = 0.0087) and 1.16% for those 75 years or older (p = 0.0026). In patients younger than 65 years, the in-hospital mortality rate was 0.13% (3 deaths among 2241 patients). As analyzed using the chi-square test (for both 65 and 75 years as the age cutoff) and the Pearson rank correlation coefficient, the risk of cardiac, pulmonary, thromboembolic, and cerebrovascular complications was higher in older patients (that is, those 65 and older and those 75 and older), but the risks of wound complications and CNS infection were not. The risk of any in-hospital complication occurring in a patient 65 years and older was 7.36% (p < 0.0001) and 10.0% in those 75 years and older (p < 0.0001). There was no difference in the total hospital charges associated with age. The duration of the hospital stay was longer in older patients, and the likelihood of discharge home was lower in older patients. Conclusions Microvascular decompression for TN in the elderly population remains a reasonable surgical option. However, based on data from a large national database, authors of the present study suggest that complications do tend to gradually increase in tandem with an advanced age. While age does not act as a risk factor in isolation, it may serve as a convenient surrogate for complication rates. The authors hope that this information can be of use in guiding older patients through decisions for the surgical treatment of TN.

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