Methylophiopogonanone A is a naturally occurring broad‐spectrum inhibitor against human UDP‐glucuronosyltransferases: inhibition behaviours and implication in herb‐drug interactions

2021 ◽  
Author(s):  
Qi‐Hang Zhou ◽  
Guang‐Hao Zhu ◽  
Yun‐Qing Song ◽  
Yuan‐Fang Que ◽  
Qing‐Qing He ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Broad Spectrum ◽  
Naturally Occurring

scholarly journals Current Approaches to the Treatment of Gastrointestinal Infections: Focus on Nitazoxanide

2009 ◽  
Vol 1 ◽  
pp. CMT.S2297 ◽  
Author(s):  
Jennifer L. Halsey
Keyword(s):  
Side Effects ◽  
Drug Interactions ◽  
Broad Spectrum ◽  
Safety Profile ◽  
Taenia Saginata ◽  
Gastrointestinal Infections ◽  
Oral Tablet ◽  
Acceptable Safety Profile ◽  
H Pylori ◽  
Immunocompetent Patients

Nitazoxanide is a broad-spectrum agent active against several protozoa, helminths, and bacteria, including C. difficile and H. pylori. It is available as an oral tablet and suspension, both with adequate bioavailability. Nitazoxanide is associated with minimal side effects, has an acceptable safety profile, and has been classified as a pregnancy category B agent. It is 99% protein bound, which could result in drug interactions. It is the preferred agent for the treatment of Cryptospordiosis and Giardiasis in immunocompetent patients and has shown promise for the treatment of rotavirus, mild to moderate initial C. difficile infection, refractory C. difficile infection, Amoebiasis, Blastocystosis, and Taenia saginata.

scholarly journals Genetic and Functional Variability of AmpC-Type β-Lactamases from Acinetobacter baumannii

2010 ◽  
Vol 54 (11) ◽  
pp. 4930-4933 ◽  
Author(s):  
José-Manuel Rodríguez-Martínez ◽  
Laurent Poirel ◽  
Patrice Nordmann
Keyword(s):  
Escherichia Coli ◽  
Acinetobacter Baumannii ◽  
Broad Spectrum ◽  
Naturally Occurring ◽  
Omega Loop

ABSTRACT The incidence of naturally occurring AmpC β-lactamases with extended activities toward several cephalosporins was evaluated among 17 ceftazidime (CAZ)-resistant Acinetobacter baumannii isolates. Five AmpC β-lactamases (named ADC β-lactamases) were identified, among which those possessing the Val208Ala (inside the omega-loop) or Asn283Ser (helix H-10) substitution conferred higher levels of resistance (4- to 64-fold higher) to CAZ and to cefotaxime in Escherichia coli. This study demonstrates that peculiar AmpCs playing a role in resistance to broad-spectrum cephalosporins in A. baumannii may be identified.

scholarly journals Antiviral and Antinematodal potentials of chitosan: Review

2020 ◽  
Vol 4 (2) ◽  
pp. 055-059
Author(s):  
Abd El-Aziz Mahmoud Hamdy ◽  
Khalil Mohamed Salah
Keyword(s):  
Broad Spectrum ◽  
Low Cost ◽  
Environmental Risks ◽  
Economic Losses ◽  
The Novel ◽  
Alternative Control ◽  
Natural Sources ◽  
Pests And Diseases ◽  
Naturally Occurring ◽  
Chemical Pesticides

For many years, chemical pesticides have been performed to control different pests and diseases and this may be due to their broad spectrum of action, easy of application and the relatively low cost. But these chemicals have environmental risks, thus alternative control agents are needed. Chitosan is one of the novel suggested solutions to reduce the economic losses associated with chemical pesticides. Chitosan is naturally-occurring compound, as well as safe and biodegradable which obtained from certain natural sources. Chitosan have unique properties which help to control viruses, bacteria, fungi, insects, plant nematodes and other pests locally and systemically.

scholarly journals Synergistic Antimicrobial Activity of Metabolites Produced by a Nonobligate Bacterial Predator

2003 ◽  
Vol 47 (7) ◽  
pp. 2113-2117 ◽  
Author(s):  
Cody C. Cain ◽  
Dongho Lee ◽  
Robert H. Waldo ◽  
Alexis T. Henry ◽  
Earl J. Casida ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Broad Spectrum ◽  
New Genus ◽  
Antimicrobial Activities ◽  
Cellular Fatty Acid ◽  
New Genus And Species ◽  
Rrna Sequence ◽  
16S Rrna Sequence ◽  
Gram Negative ◽  
Naturally Occurring

ABSTRACT A naturally occurring, gram-negative, nonobligate predator bacterial strain 679-2, exhibits broad-spectrum antimicrobial activity that is due, in part, to the production of three extracellular compounds. Antimicrobial-activity-directed fractionation of a culture of strain 679-2 against a panel of microorganisms has led to the isolation of three compounds: pyrrolnitrin, maculosin, and a new compound, which we have named banegasine. Although pyrrolnitrin is well known in the literature, it has not been found in cells with the herbicide maculosin. Further, this is the first report of production of maculosin by a prokaryote. Both maculosin and banegasine, which displayed no antimicrobial activities alone, were found to potentiate the antimicrobial activity of pyrrolnitrin. Based on 16S rRNA sequence, cellular fatty acid composition, and biochemical and cultural characteristics, strain 679-2 appears to represent a new genus and species of eubacteria, Aristabacter necator. The potent, broad-spectrum antimicrobial activity of predator strain 679-2 may be due to synergism between metabolites.

scholarly journals BIOLOGICAL ACTIVITIES AND NOVEL APPLICATIONS OF CHALCONES

2016 ◽  
Vol 34 (3) ◽  
pp. 607-616 ◽  
Author(s):  
C. DÍAZ-TIELAS ◽  
E. GRAÑA ◽  
M.J. REIGOSA ◽  
A.M. SÁNCHEZ-MOREIRAS
Keyword(s):  
Secondary Metabolites ◽  
Broad Spectrum ◽  
Biological Activities ◽  
Crop Protection ◽  
Plant Secondary Metabolites ◽  
Naturally Occurring ◽  
Molecular Events ◽  
Novel Applications ◽  
New Applications ◽  
Synthetic Derivatives

ABSTRACT This review provides information on the biological activities of chalcones (whether natural or synthetic derivatives) on different organisms, as well as an overview of the functions and possible new applications of these plant secondary metabolites on crop protection, as eco-friendly pesticides and weed control agents. Naturally occurring chalcones have been used in traditional medicine for many years; however, recent scientific advances have shown that these molecules have a broad range of biological activities in a variety of organisms. A review on the major sources of chalcones and the main molecular events involved in the modes of action of these natural products is achieved. Chalcones are molecules with a broad spectrum of biological activities, which are of great interest in agriculture to control weeds and unwanted pests.

scholarly journals Shaping Substrate Selectivity in a Broad-Spectrum Metallo-β-Lactamase

2018 ◽  
Vol 62 (4) ◽  
Author(s):  
Lisandro J. González ◽  
Cintia Stival ◽  
Juan L. Puzzolo ◽  
Diego M. Moreno ◽  
Alejandro J. Vila
Keyword(s):  
Broad Spectrum ◽  
Active Site ◽  
Substrate Recognition ◽  
Chimeric Protein ◽  
Major Group ◽  
Substrate Selectivity ◽  
Incomplete Knowledge ◽  
Naturally Occurring ◽  
The One

ABSTRACTMetallo-β-lactamases (MBLs) are the major group of carbapenemases produced by bacterial pathogens. The design of MBL inhibitors has been limited by, among other issues, incomplete knowledge about how these enzymes modulate substrate recognition. While most MBLs are broad-spectrum enzymes, B2 MBLs are exclusive carbapenemases. This narrower substrate profile has been attributed to a sequence insertion present in B2 enzymes that limits accessibility to the active site. In this work, we evaluate the role of sequence insertions naturally occurring in the B2 enzyme Sfh-I and in the broad-spectrum B1 enzyme SPM-1. We engineered a chimeric protein in which the sequence insertion of SPM-1 was replaced by the one present in Sfh-I. The chimeric variant is a selective cephalosporinase, revealing that the substrate profile of MBLs can be further tuned depending on the protein context. These results also show that the stable scaffold of MBLs allows a modular engineering much richer than the one observed in nature.

scholarly journals Computational design of anti-CRISPR proteins with improved inhibition potency and expanded specificity

2019 ◽  
Author(s):  
Jan Mathony ◽  
Zander Harteveld ◽  
Carolin Schmelas ◽  
Julius Upmeier zu Belzen ◽  
Sabine Aschenbrenner ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Broad Spectrum ◽  
Potent Inhibitor ◽  
Computational Design ◽  
Type Ii ◽  
Innovative Strategy ◽  
Naturally Occurring ◽  
Mining Sequence ◽  
Inhibition Potency

AbstractAnti-CRISPR (Acr) proteins are bacteriophage-derived antagonists of CRISPR-Cas systems. To date, Acrs were obtained either by mining sequence databanks or experimentally screening phage collections, both of which yield a limited repertoire of naturally occurring variants. Here, we applied structure-based engineering on AcrIIC1, a broad-spectrum inhibitor of type II-C CRISPR systems, to improve its efficacy and expand its specificity. We first show that fusing exogenous protein domains into AcrIIC1 dramatically enhances inhibition of the natural Neisseria meningitidis Cas9 target. Then, using structure-guided design, we converted AcrIIC1 into AcrX, a potent inhibitor of the type II-A CRISPR-Cas9 from Staphylococcus aureus widely applied for in vivo genome editing. Our work introduces designer Acrs as important biotechnological tools and provides an innovative strategy to safeguard the CRISPR technology.

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