scholarly journals Targeting of cancer cell death mechanisms by curcumin; implications to cancer therapy

2021 ◽  
Author(s):  
Chong Yu ◽  
Bo Yang ◽  
Masoud Najafi
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Cell Death Mechanisms

Magneto Mitochondrial Dysfunction Mediated Cancer Cell Death Using Intracellular Magnetic Nano-Transducers

2021 ◽  
Author(s):  
Wooram Park ◽  
Seok-Jo Kim ◽  
Paul Cheresh ◽  
Jeanho Yun ◽  
Byeongdu Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Cancer Cell ◽  
High Sensitivity ◽  
Intrinsic Pathway ◽  
Cancer Cell Death

Mitochondria are crucial regulators of the intrinsic pathway of cancer cell death. The high sensitivity of cancer cells to mitochondrial dysfunction offers opportunities for emerging targets in cancer therapy. Herein,...

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

2018 ◽  
Vol 147 ◽  
pp. 170-182 ◽  
Author(s):  
Punya Bhat ◽  
Jurgen Kriel ◽  
Babu Shubha Priya ◽  
Basappa ◽  
Nanjunda Swamy Shivananju ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Cancer Cell Death

scholarly journals Cold Physical Plasma in Cancer Therapy: Mechanisms, Signaling, and Immunity

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Fatemeh Faramarzi ◽  
Parisa Zafari ◽  
Mina Alimohammadi ◽  
Mohammadreza Moonesi ◽  
Alireza Rafiei ◽  
...  
Keyword(s):  
Cell Death ◽  
Immune System ◽  
Cancer Therapy ◽  
Plasma Treatment ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Intracellular Signaling ◽  
Current Knowledge ◽  
Cancer Cell Death ◽  
Physical Plasma

Despite recent advances in therapy, cancer still is a devastating and life-threatening disease, motivating novel research lines in oncology. Cold physical plasma, a partially ionized gas, is a new modality in cancer research. Physical plasma produces various physicochemical factors, primarily reactive oxygen and nitrogen species (ROS/RNS), causing cancer cell death when supplied at supraphysiological concentrations. This review outlines the biomedical consequences of plasma treatment in experimental cancer therapy, including cell death modalities. It also summarizes current knowledge on intracellular signaling pathways triggered by plasma treatment to induce cancer cell death. Besides the inactivation of tumor cells, an equally important aspect is the inflammatory context in which cell death occurs to suppress or promote the responses of immune cells. This is mainly governed by the release of damage-associated molecular patterns (DAMPs) to provoke immunogenic cancer cell death (ICD) that, in turn, activates cells of the innate immune system to promote adaptive antitumor immunity. The pivotal role of the immune system in cancer treatment, in general, is highlighted by many clinical trials and success stories on using checkpoint immunotherapy. Hence, the potential of plasma treatment to induce ICD in tumor cells to promote immunity targeting cancer lesions systemically is also discussed.

Targeting of cancer cell death mechanisms by resveratrol: a review

APOPTOSIS ◽  
2021 ◽  
Author(s):  
Xiao Fu ◽  
Mu Li ◽  
Cuilian Tang ◽  
Zezhi Huang ◽  
Masoud Najafi
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Cell Death Mechanisms

scholarly journals Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Xuanbin Wang ◽  
Yibin Feng ◽  
Ning Wang ◽  
Fan Cheung ◽  
Hor Yue Tan ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Scientific Evidence ◽  
Cellular Mechanisms ◽  
Dominant Type ◽  
Chinese Medicines ◽  
Related Information ◽  
Cancer Cell Death ◽  
The Relationship

Chinese medicines have long history in treating cancer. With the growing scientific evidence of biomedical researches and clinical trials in cancer therapy, they are increasingly accepted as a complementary and alternative treatment. One of the mechanisms is to induce cancer cell death.Aim. To comprehensively review the publications concerning cancer cell death induced by Chinese medicines in recent years and provide insights on anticancer drug discovery from Chinese medicines.Materials and Methods. Chinese medicines (including Chinese medicinal herbs, animal parts, and minerals) were used in the study. The key words including “cancer”, “cell death”, “apoptosis”, “autophagy,” “necrosis,” and “Chinese medicine” were used in retrieval of related information from PubMed and other databases.Results. The cell death induced by Chinese medicines is described as apoptotic, autophagic, or necrotic cell death and other types with an emphasis on their mechanisms of anticancer action. The relationship among different types of cell death induced by Chinese medicines is critically reviewed and discussed.Conclusions. This review summarizes that CMs treatment could induce multiple pathways leading to cancer cell death, in which apoptosis is the dominant type. To apply these preclinical researches to clinic application will be a key issue in the future.

Cancer cell death

2016 ◽  
pp. 42-48
Author(s):  
Amanda S. Coutts ◽  
Sandra Maniam ◽  
Nicholas B. La Thangue
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Control Cell ◽  
Clinical Importance ◽  
Signalling Pathways ◽  
Cancer Treatments ◽  
Cell Death Pathways ◽  
Cancer Cell Death ◽  
Cell Death Mechanisms ◽  
Apoptotic Pathways

Inducing cancer cell death is the basis of the majority of cancer treatments and understanding the mechanisms that control cell death is of prime clinical importance. As a defining feature of cancer is the ability to circumvent cell death pathways, understanding the mechanisms involved is also important in the development of novel therapeutic agents. This chapter outlines three main mechanisms involved in cancer cell death—apoptosis, necroptosis, and autophagy—to give an overview of some of the specific pathways involved. There are a plethora of genetic and epigenetic changes in tumour cells that can circumvent apoptotic pathways; as such understanding and developing therapies that can target other death-signalling pathways could have great clinical significance. Given the complexity involved in the variety of cell death mechanisms, the challenge in oncology is how to harness these different modes of cell death in order to effectively eliminate cancer cells.

scholarly journals Selective induction of cancer cell death by VDAC 1‐based peptides and their potential use in cancer therapy

2018 ◽  
Vol 12 (7) ◽  
pp. 1077-1103 ◽  
Author(s):  
Anna Shteinfer‐Kuzmine ◽  
Zohar Amsalem ◽  
Tasleem Arif ◽  
Alexandra Zooravlov ◽  
Varda Shoshan‐Barmatz
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Cancer Cell Death ◽  
Potential Use
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