scholarly journals Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain

2020 ◽  
Vol 127 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Sara I. Graves ◽  
Darren J. Baker
Keyword(s):  
Endothelial Cell ◽  
Cell Senescence

Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway

2021 ◽  
Author(s):  
Liang Zhang ◽  
Manli Liu ◽  
Wenhua Liu ◽  
Chaojie Hu ◽  
Hongqi Li ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Signaling Pathway ◽  
Cell Senescence

17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53

2018 ◽  
Vol 114 ◽  
pp. 57-66 ◽  
Author(s):  
Shicong Song ◽  
Saizhu Wu ◽  
Yuyan Wang ◽  
Zhiwei Wang ◽  
Changxiong Ye ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Vascular Endothelial Cell ◽  
Cell Senescence ◽  
Vascular Endothelial ◽  
17Β Estradiol

scholarly journals Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression

Aging ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 20946-20967
Author(s):  
Ok-Hee Lee ◽  
Yun Mi Woo ◽  
Sohyeon Moon ◽  
Jihyun Lee ◽  
Haeun Park ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Senescence ◽  
Forkhead Box ◽  
Forkhead Box M1

scholarly journals Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging

2021 ◽  
Vol 9 ◽  
Author(s):  
Fei Ge ◽  
Qi Pan ◽  
Yue Qin ◽  
Mengping Jia ◽  
Chengchao Ruan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Endothelial Cell ◽  
Single Cell ◽  
Coronary Arteries ◽  
Cell Senescence ◽  
Open Chromatin ◽  
Vegf Receptor ◽  
Aged Mouse ◽  
Vascular Aging ◽  
Master Regulator

Vascular aging is a potent driver of cardiovascular and cerebrovascular diseases. Vascular aging features cellular and functional changes, while its molecular mechanisms and the cell heterogeneity are poorly understood. This study aims to 1) explore the cellular and molecular properties of aged cardiac vasculature in monkey and mouse and 2) demonstrate the role of transcription factor BACH1 in the regulation of endothelial cell (EC) senescence and its mechanisms. Here we analyzed published single-cell RNA sequencing (scRNA-seq) data from monkey coronary arteries and aortic arches and mouse hearts. We revealed that the gene expression of YAP1, insulin receptor, and VEGF receptor 2 was downregulated in both aged ECs of coronary arteries’ of monkey and aged cardiac capillary ECs of mouse, and proliferation-related cardiac capillary ECs were significantly decreased in aged mouse. Increased interaction of ECs and immunocytes was observed in aged vasculature of both monkey and mouse. Gene regulatory network analysis identified BACH1 as a master regulator of aging-related genes in both coronary and aorta ECs of monkey and cardiac ECs of mouse. The expression of BACH1 was upregulated in aged cardiac ECs and aortas of mouse. BACH1 aggravated endothelial cell senescence under oxidative stress. Mechanistically, BACH1 occupied at regions of open chromatin and bound to CDKN1A (encoding for P21) gene enhancers, activating its transcription in senescent human umbilical vein endothelial cells (HUVECs). Thus, these findings demonstrate that BACH1 plays an important role in endothelial cell senescence and vascular aging.

Abstract 514: Netrin 4 Deficiency Leads to Endothelial Cell Senescence

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
HUAYU ZHANG ◽  
Dianne Vreeken ◽  
Ruben G de Bruin ◽  
Danielle G Leuning ◽  
Mehdi Maanaoui ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Senescence

scholarly journals Bradykinin Protects Against Oxidative Stress–Induced Endothelial Cell Senescence

Hypertension ◽  
2009 ◽  
Vol 53 (2) ◽  
pp. 417-422 ◽  
Author(s):  
Hisko Oeseburg ◽  
Dilek Iusuf ◽  
Pim van der Harst ◽  
Wiek H. van Gilst ◽  
Robert H. Henning ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cell ◽  
Cell Senescence

scholarly journals mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway

2018 ◽  
Vol 39 (12) ◽  
pp. 1837-1846 ◽  
Author(s):  
Han-wei Yang ◽  
Hui-ling Hong ◽  
Wen-wei Luo ◽  
Chun-mei Dai ◽  
Xin-yi Chen ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Signaling Pathway ◽  
Cell Senescence ◽  
Gsk 3Β ◽  
Nrf2 Expression

scholarly journals C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy

2021 ◽  
Vol 521 ◽  
pp. 111114
Author(s):  
Jiwoo Lee ◽  
Jee Hee Yoo ◽  
Hwi Seung Kim ◽  
Yun Kyung Cho ◽  
Yoo La Lee ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Palmitic Acid ◽  
Cell Senescence ◽  
Related Protein
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