scholarly journals Effects of inorganic nitrate in a rat model of monocrotaline‐induced pulmonary arterial hypertension

2019 ◽  
Vol 126 (2) ◽  
pp. 99-109
Author(s):  
Eva Malikova ◽  
Mattias Carlström ◽  
Zuzana Kmecova ◽  
Margareta Marusakova ◽  
Bianka Zsigmondova ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Rat Model ◽  
Inorganic Nitrate ◽  
Pulmonary Arterial

Safflower injection inhibits pulmonary arterial remodeling in a monocrotaline-induced pulmonary arterial hypertension rat model

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Aifeng Chen ◽  
Shibiao Ding ◽  
Liangliang Kong ◽  
Jianpu Xu ◽  
Fei He ◽  
...  
Keyword(s):  
Growth Factor ◽  
Pulmonary Arterial Hypertension ◽  
Pulmonary Artery ◽  
Arterial Hypertension ◽  
Cardiac Muscle ◽  
Rat Model ◽  
Dependent Manner ◽  
Arterial Remodeling ◽  
Pulmonary Arterial ◽  
Dose Dependent

AbstractPulmonary arterial hypertension (PAH) is a group of diseases with an increase of pulmonary artery pressure (PAP) and pulmonary vascular resistance. Here, the effects of safflower injection, a preparation of Chinese herbs, was investigated in a monocrotaline (MCT)-induced PAH rat model. PAP, carotid artery pressure (CAP), and the right ventricular hypertrophy index (RVHI) increased in the PAH group, while safflower injection was able to inhibit this increase to similar levels as observed in the normal group. The arteriole wall of the lungs and cardiac muscle were thickened and edema was observed in the PAH group, while these pathologies were improved in the herb-treated group in a dose-dependent manner. MCT treatment induced proliferation of pulmonary artery smooth muscle cells (PASMCs), which was inhibited by safflower injection in a dose-dependent manner. Our experimental results demonstrated that safflower injection can regulate pulmonary arterial remodeling through affecting the expression of connective tissue growth factor, transforming growth factor-β, integrin, collagen or fibronectin, which subsequently affected the thicknesses of the arteriole walls of the lungs and cardiac muscle, and thereby benefits the control of PAH. This means safflower injection improved the abnormalities in PAP, CAP and RVHI, and pulmonary arterial remodeling through regulation of remodeling factors.

scholarly journals Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Mateusz K. Hołda ◽  
Elżbieta Szczepanek ◽  
Joanna Bielawska ◽  
Natalia Palka ◽  
Dorota Wojtysiak ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Rat Model ◽  
Morphometric Parameters ◽  
Pulmonary Arterial

scholarly journals Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tingting Zhang ◽  
Nanako Kawaguchi ◽  
Kenji Yoshihara ◽  
Emiko Hayama ◽  
Yoshiyuki Furutani ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Rat Model ◽  
Chronic Hypoxia ◽  
Pulmonary Arterial

Echocardiographic evaluation of pharmacological antagonism of endothelin receptors in a rat model of pulmonary arterial hypertension

2020 ◽  
Vol 132 ◽  
pp. 106706
Author(s):  
Silvia Cantoni ◽  
Massimiliano Cont ◽  
Stefano Cavalli ◽  
Alessandro Fioni ◽  
Alice Pappani ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Rat Model ◽  
Endothelin Receptors ◽  
Echocardiographic Evaluation ◽  
Pulmonary Arterial
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