scholarly journals Meta-analysis of the Influence of UGT Genetic Polymorphisms on Lamotrigine Concentration

2018 ◽  
Vol 124 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Su Cheol Kim ◽  
Myeong Gyu Kim
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Lamotrigine Concentration

Genetic Polymorphisms and the Risk of Diabetic Foot: A Systematic Review and Meta-Analyses

2020 ◽  
pp. 153473462097759
Author(s):  
Jun Zhao ◽  
Le-Xuan Zhang ◽  
Yu-Ting Wang ◽  
Yang Li ◽  
Hong-Lin Chen, MD
Keyword(s):  
Genetic Polymorphisms ◽  
Diabetic Foot ◽  
Protective Factor ◽  
Meta Analysis ◽  
Nucleotide Polymorphisms ◽  
Asian Populations ◽  
Tnf Α ◽  
Newcastle Ottawa Scale ◽  
Meta Analyses ◽  
Relationship Of

Background Diabetic foot (DF) is a dangerous complication of diabetes. The aim of the study was to synthesize all the published single nucleotide polymorphisms (SNPs) of DF to objectively evaluate the relationship of SNPs and DF risks. Methods The HuGE database and CNKI were searched for eligible publications on genetic polymorphisms and the risk of DF systematically. The quality of literatures was evaluated by the Newcastle-Ottawa scale. Pooled odds ratios with a 95% confidence interval for SNPs were evaluated through 3 genetic models. Results Citing 29 different polymorphisms from 24 articles and the study met our selection criteria. There were 24 polymorphisms summarized systematically, and 5 merged polymorphisms for a meta-analysis: 9 positively associated with DF: HIF-1α rs11549465, TNF-α rs1800629, TLR-9 rs5743836, FIB rs6056, HSP70-2437C/T, VDR rs2228570, LOX rs1800449, ITLN1 rs2274907, and OPG rs2073617, but OPG rs3134069 was not a risk factor in DF; 6 negatively associated with DF: VEGF rs833061 and rs2010963, MCP-1 rs1024611, SDF-1 rs1801157, SIRT1 rs12778366, and OPG rs2073617. In addition, 13 polymorphisms were not associated with DF: MMP-9 rs3918242, eNOS rs1799983, VEGF rs3025039, -7C/T, rs1570360, rs13207351, and rs699947, IL-6 rs1800795, HIF-1α rs11549467, TNF-α rs361525, TLR-2 rs3804100, SIRT1 rs3758391, and TIMP-1 rs2070584. Conclusions The study provided some evidence for SNPs to the development of diabetic foot. The meta-analysis showed that rs1024611 of MCP-1 may be regarded as a protective factor, especially in Asian populations. Other loci indicated inconsistent results.

Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics

2011 ◽  
Vol 68 (5) ◽  
pp. 645-655 ◽  
Author(s):  
Meghan Brennan ◽  
J. Andrew Williams ◽  
Ying Chen ◽  
Michael Tortorici ◽  
Yazdi Pithavala ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Drug Metabolizing Enzymes ◽  
Metabolizing Enzymes

Calpain-10 genetic polymorphisms and polycystic ovary syndrome risk: A meta-analysis and meta-regression

Gene ◽  
2013 ◽  
Vol 531 (2) ◽  
pp. 426-434 ◽  
Author(s):  
Wenjing Shen ◽  
Tianren Li ◽  
Yanjie Hu ◽  
Hongbo Liu ◽  
Min Song
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Polymorphisms ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Ovary Syndrome ◽  
Calpain 10 ◽  
Meta Regression

scholarly journals Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies

2018 ◽  
Vol Volume 11 ◽  
pp. 1237-1248 ◽  
Author(s):  
Yu-jiao Wu ◽  
Xin Yang ◽  
Ting-di Chen ◽  
Zhi-xin Zhang ◽  
Yi-zhong You ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Asian Populations ◽  
Exon 1 ◽  
Tuberculosis Risk

Associations of TIM-1 Genetic Polymorphisms with Asthma: A Meta-analysis

Lung ◽  
2017 ◽  
Vol 195 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Xiaochuan Xie ◽  
Xiaohan Shi ◽  
Peng Chen ◽  
Li Rao
Keyword(s):  
Genetic Polymorphisms ◽  
Meta Analysis

Genetic polymorphisms of XRCC3 Thr241Met (C18067T, rs861539) and bladder cancer risk: a meta-analysis of 18 research studies

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1473-1480 ◽  
Author(s):  
Qingtong Ma ◽  
Yumei Zhao ◽  
Shoufeng Wang ◽  
Xiaoyan Zhang ◽  
Jinling Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Bladder Cancer Risk ◽  
Xrcc3 Thr241met ◽  
Research Studies

Relationships Between CYP1A1 Genetic Polymorphisms and Bladder Cancer Risk: A Meta-Analysis

2014 ◽  
Vol 33 (3) ◽  
pp. 171-181 ◽  
Author(s):  
Yi Wang ◽  
Chui-Ze Kong ◽  
Zhe Zhang ◽  
Chun-Ming Yang ◽  
Jun Li
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Bladder Cancer Risk
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