scholarly journals The Effect of a Combination of Diclofenac and Methadone Applied as Gel in a Human Experimental Pain Model - A Randomized, Placebo-controlled Trial

2018 ◽  
Vol 123 (2) ◽  
pp. 188-194 ◽  
Author(s):  
Isabelle M. Larsen ◽  
Asbjørn M. Drewes ◽  
Anne E. Olesen
Keyword(s):  
Controlled Trial ◽  
Experimental Pain ◽  
Pain Model

scholarly journals Evaluation of an Experimental Pain Model by Noncompartmental Analysis of Results from a Randomized Placebo Controlled Trial

2018 ◽  
Vol 1 (21;1) ◽  
pp. 363-372
Author(s):  
France Varin
Keyword(s):  
Active Treatment ◽  
Controlled Trial ◽  
Experimental Pain ◽  
The Elderly ◽  
Pain Tolerance ◽  
Age Group ◽  
Noncompartmental Analysis ◽  
Time Curve ◽  
Pain Model ◽  
Significant Difference

Background: Understanding analgesic pharmacodynamics (PD) in the elderly is key to optimising pain management. Electrically stimulated pain models (ESPM) permit assessment of pain responses in humans. C and Aδ sensory fibres convey pain and respond to low frequency electrical stimulus (5 and 250 Hz, respectively). Human research suggests pain tolerance threshold (PTT) is similar or decreases with age. Objectives: To determine whether an ESPM is able to detect a difference in PTT in elderly (≥ 75 years) and young (20-40 years) subjects after single dose administration of a placebo and tramadol, a low potency analgesic. Study Design: Two-cohort, randomized, placebo-controlled, cross-over study. Methods: A noncompartmental analysis of data at 17 timepoints on 5 Hz and 250 Hz PTT over 24 h. Results: Young (16) and elderly (13) patients showed similar baseline (E0) PTT between active and placebo both overall and by age group in both frequencies. Net drug effect took into account negative and positive changes from E0. In the elderly, net peak effect on PTT produced by active treatment was significantly greater for both 5 Hz (34%) and 250 Hz (30%). Net area under the 24-h effect-time curve during active treatment was significantly higher for both 5 Hz (163 %) and 250 Hz (175%) stimulations in the elderly. No clinically significant difference was observed in the young. Limitations: High variability in young subjects, despite efforts to remove outliers limited our ability to draw conclusions in that age group. Generalizability of results obtained from an experimental pain model in volunteers to treatment of elderly patients may be limited. Conclusion: ESPM can detect a difference for pain tolerance threshold between placebo and tramadol administration in the elderly. Although both 5 Hz and 250 Hz stimulations can detect a difference, the effect size for 5 Hz is larger and seems more precise and reliable, particularly in the elderly. Key words: Electrical pain model, elderly, geriatric, tramadol, placebo, opioid, area under the effect curve, noncompartmental analysis

The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial

Pain ◽  
2014 ◽  
Vol 155 (12) ◽  
pp. 2510-2516 ◽  
Author(s):  
Yvonne Boyle ◽  
Disala Fernando ◽  
Hazel Kurz ◽  
Sam R. Miller ◽  
Mauro Zucchetto ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Healthy Volunteers ◽  
Controlled Trial ◽  
Experimental Pain ◽  
Pain Model ◽  
Randomized Controlled

Pharmacokinetic-Pharmacodynamic Modeling of Morphine and Oxycodone Concentrations and Analgesic Effect in a Multimodal Experimental Pain Model

2008 ◽  
Vol 48 (5) ◽  
pp. 619-631 ◽  
Author(s):  
Camilla Staahl ◽  
Richard Upton ◽  
David J. R. Foster ◽  
Lona Louring Christrup ◽  
Kim Kristensen ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Experimental Pain ◽  
Pharmacodynamic Modeling ◽  
Pain Model

Utility and Sensitivity of the Sore Throat Pain Model: Results of a Randomized Controlled Trial on the COX-2 Selective Inhibitor Valdecoxib

2007 ◽  
Vol 47 (7) ◽  
pp. 860-870 ◽  
Author(s):  
Bernard P. Schachtel ◽  
Sharon Pan ◽  
Joseph D. Kohles ◽  
Kathleen M. Sanner ◽  
Emily P. Schachtel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Sore Throat ◽  
Controlled Trial ◽  
Selective Inhibitor ◽  
Pain Model ◽  
Throat Pain ◽  
Randomized Controlled ◽  
Cox 2
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