scholarly journals The Influence of Oral Antidiabetic Drugs on Cellular Drug Uptake Mediated by Hepatic OATP Family Members

2012 ◽  
Vol 112 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Sabine Klatt ◽  
Martin F. Fromm ◽  
Jörg König
Keyword(s):  
Family Members ◽  
Antidiabetic Drugs ◽  
Drug Uptake ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic

scholarly journals Managing pasireotide-associated hyperglycemia: a randomized, open-label, Phase IV study

Pituitary ◽  
2021 ◽  
Author(s):  
Susan L. Samson ◽  
Feng Gu ◽  
Ulla Feldt-Rasmussen ◽  
Shaoling Zhang ◽  
Yerong Yu ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Rescue Therapy ◽  
Antidiabetic Drugs ◽  
Cushing's Disease ◽  
Oral Antidiabetic Drugs ◽  
Open Label ◽  
Oral Antidiabetic ◽  
Open Label Phase ◽  
Core Phase ◽  
Phase Iv

Abstract Purpose Pasireotide is an effective treatment for acromegaly and Cushing’s disease, although treatment-emergent hyperglycemia can occur. The objective of this study was to assess incretin-based therapy versus insulin for managing pasireotide-associated hyperglycemia uncontrolled by metformin/other permitted oral antidiabetic drugs. Methods Multicenter, randomized, open-label, Phase IV study comprising a core phase (≤ 16-week pre-randomization period followed by 16-week randomized treatment period) and optional extension (ClinicalTrials.gov ID: NCT02060383). Adults with acromegaly (n = 190) or Cushing’s disease (n = 59) received long-acting (starting 40 mg IM/28 days) or subcutaneous pasireotide (starting 600 µg bid), respectively. Patients with increased fasting plasma glucose (≥ 126 mg/dL on three consecutive days) during the 16-week pre-randomization period despite metformin/other oral antidiabetic drugs were randomized 1:1 to open-label incretin-based therapy (sitagliptin followed by liraglutide) or insulin for another 16 weeks. The primary objective was to evaluate the difference in mean change in HbA1c from randomization to end of core phase between incretin-based therapy and insulin treatment arms. Results Eighty-one (32.5%) patients were randomized to incretin-based therapy (n = 38 received sitagliptin, n = 28 subsequently switched to liraglutide; n = 12 received insulin as rescue therapy) or insulin (n = 43). Adjusted mean change in HbA1c between treatment arms was – 0.28% (95% CI – 0.63, 0.08) in favor of incretin-based therapy. The most common AE other than hyperglycemia was diarrhea (incretin-based therapy, 28.9%; insulin, 30.2%). Forty-six (18.5%) patients were managed on metformin (n = 43)/other OAD (n = 3), 103 (41.4%) patients did not require any oral antidiabetic drugs and 19 patients (7.6%) were receiving insulin at baseline and were not randomized. Conclusion Many patients receiving pasireotide do not develop hyperglycemia requiring oral antidiabetic drugs. Metformin is an effective initial treatment, followed by incretin-based therapy if needed. ClinicalTrials.gov ID: NCT02060383.

Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1

2012 ◽  
Vol 41 (3) ◽  
pp. 592-601 ◽  
Author(s):  
E. van de Steeg ◽  
R. Greupink ◽  
M. Schreurs ◽  
I.H.G. Nooijen ◽  
K.C.M. Verhoeckx ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Antidiabetic Drugs ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic

Oral antidiabetic drugs in pregnancy

1963 ◽  
Vol 1 (2) ◽  
pp. 8.1-8
Keyword(s):  
Congenital Abnormalities ◽  
Diabetic Control ◽  
Antidiabetic Drugs ◽  
Oral Antidiabetic Drugs ◽  
Human Foetus ◽  
Oral Antidiabetic ◽  
High Doses ◽  
Sulphonylurea Derivatives ◽  
Diabetic Mothers ◽  
In Pregnancy

A recent report casts doubt on the safety of oral antidiabetic drugs in pregnancy by suggesting that chlorpropamide (Diabinese - Pfizer), in high doses is associated with a high perinatal mortality (Brit. med. J. 1963, 1, 59). Out of 19 diabetic mothers who received 500 mg of the drug daily, 14 (74%) had perinatal loss. It is not clear whether this is due to inadequate diabetic control or to some direct effect of the chlorpropamide. Confirmation of these results is desirable and more information about the effects of other antidiabetic sulphonylurea derivatives in pregnancy (for example, tolbutamide) is also needed. There is little evidence that oral antidiabetic drugs induce congenital abnormalities in the human foetus, although cases have been reported (Lancet 1960, 2, 1424; 1961, 1, 891). The British manufacturers of oral antidiabetic drugs warn against their use in pregnancy.

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