Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma

2021 ◽  
Author(s):  
Mourad Hamimed ◽  
Florence Gattacceca ◽  
Nicolas André ◽  
Emmanuelle Tresch‐Bruneel ◽  
Alicia Probst ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Low Grade ◽  
Oral Vinorelbine

scholarly journals LGG-54. ORAL VINORELBINE IN PROGRESSIVE UNRESECTABLE LOW-GRADE GLIOMA: EXPERIENCE OF A SINGLE INSTITUTION

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i116-i116
Author(s):  
Andrea Cappellano ◽  
Cynthia M Silveira ◽  
Milena RS Oliveira ◽  
Sergio Cavalheiro ◽  
Patricia Dastoli ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Low Grade ◽  
Single Institution ◽  
Oral Vinorelbine

scholarly journals LINC-26. ORAL VINORELBINE IN PROGRESSIVE UNRESECTABLE LOW-GRADE GLIOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii383-iii383
Author(s):  
Andréa M Cappellano ◽  
Milena R S Oliveira ◽  
Sergio Cavalheiro ◽  
Patricia Dastoli ◽  
Daniela B Almeida ◽  
...  
Keyword(s):  
Objective Response ◽  
Vinca Alkaloid ◽  
Neurofibromatosis Type ◽  
Low Grade Glioma ◽  
Optic Pathway Glioma ◽  
Low Grade ◽  
Visual Evaluation ◽  
Oral Vinorelbine ◽  
Grade Ii

Abstract BACKGROUND The management of progressive unresectable low-grade glioma (PULGG) remains controversial. Some series suggests that chemotherapy may delay or even avoid radiotherapy and/or surgery in a group of patients. Within this context, we performed at IOP/GRAACC/UNIFESP an institutional protocol with IV vinorelbine, a semi-synthetic vinca alkaloid that showed activity against PULGG. The objective of this study was to evaluate the response as long as the tolerability of oral vinorelbine in PULGG. PATIENTS AND METHODS From April 2013 to Aug 2017, 17 patients with recurrent (n=5) and newly-diagnosed (n=12) optic-pathway glioma (OPG) were treated with oral vinorelbine in a dose of 90 mg/m² days 0, 8 and 22 for 18 cycles. Response criteria used a combination of magnetic resonance imaging, physical and visual evaluation. RESULTS Mean age 8.6 years (4.8–17.9y). Three children with neurofibromatosis type 1. Eleven patients had neurosurgical intervention revealing grade I (n=8) and grade II astrocytoma (n=3). Twelve patients were assessable after 8 cycles of vinorelbine with 2 objective response (OR), 8 stable disease (SD) and 2 progressive disease (PD), one died after surgery and 1 alive in different protocol. After 18 cycles, eight patients were assessable to date for response with 1 OR, 7 SD. The most important toxicity was gastrointestinal observed in 12 patients- six of them switched to IV vinorelbine (3OR, 3SD). None of the patients showed neurotoxicity. CONCLUSION These results suggest that oral vinorelbine, as the IV formulation, may show some activity in OPG. However, gastrointestinal toxicity should be considered.

Development of a novel assay suitable for pre-clinical testing of MAPK inhibitors in low-grade glioma

2017 ◽  
Author(s):  
D Usta ◽  
F Selt ◽  
J Hohloch ◽  
S Pusch ◽  
SM Pfister ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Low Grade ◽  
Clinical Testing ◽  
Mapk Inhibitors

scholarly journals Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

2021 ◽  
Vol 22 (3) ◽  
pp. 184-195
Author(s):  
Lily Deland ◽  
Simon Keane ◽  
Thomas Olsson Bontell ◽  
Helene Sjögren ◽  
Henrik Fagman ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Targeted Treatment ◽  
Low Grade

scholarly journals Automatic segmentation of low-grade glioma in MRI image based on UNet++ model

2020 ◽  
Vol 1693 ◽  
pp. 012135
Author(s):  
Dan Xu ◽  
Xidong Zhou ◽  
Xuefen Niu ◽  
Junwei Wang
Keyword(s):  
Automatic Segmentation ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Mri Image

scholarly journals Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult

2021 ◽  
pp. 179-183
Author(s):  
Ann-Kristin Becker ◽  
Marta Leonora Frank ◽  
Michael Friese ◽  
Joachim Röther
Keyword(s):  
Brain Tumor ◽  
Back Pain ◽  
Young Adult ◽  
Lower Back Pain ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Who Grade ◽  
Leptomeningeal Spread ◽  
Lower Back ◽  
Uncommon Case

The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern. Here we present a rare and uncommon case of a primary leptomeningeal glioblastoma in combination with a low-grade glioma in a 21-year-old male, initially presenting with only headache and lower back pain. The presented case illustrates the challenging differential considerations and the severe course of leptomeningeal glioblastomas.

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