Trough polymyxin B plasma concentration is an independent risk factor for its nephrotoxicity

2021 ◽  
Author(s):  
Lu Han ◽  
Fang‐Min Xu ◽  
Xiao‐Shan Zhang ◽  
Chun‐Hong Zhang ◽  
Ying Dai ◽  
...  
Keyword(s):  
Risk Factor ◽  
Plasma Concentration ◽  
Independent Risk Factor ◽  
Polymyxin B

Elevated D-dimer level is an independent risk factor for cardiovascular death in out-patients with symptoms compatible with heart failure

2004 ◽  
Vol 92 (12) ◽  
pp. 1250-1258 ◽  
Author(s):  
Ulf Dahlström ◽  
Tomas Lindahl ◽  
Urban Alehagen
Keyword(s):  
Heart Failure ◽  
Risk Factor ◽  
Plasma Concentration ◽  
Cardiovascular Mortality ◽  
Independent Risk Factor ◽  
Systolic Function ◽  
Venous Flow ◽  
Increased Risk ◽  
Patients With Heart Failure ◽  
D Dimer

SummaryD-dimer, a marker of fibrin turnover, exhibits many interesting properties as a biological marker of thrombosis. Some of the properties of D-dimer might also be used to provide additional information about patients with heart failure. In this study, we evaluate the prognostic information acquired from D-dimer concerning increased risk of cardiovascular mortality in an elderly population with symptoms associated with heart failure. A cardiologist examined 458 elderly patients, out of 548 invited, attending primary care for symptoms of dyspnoea, fatigue and/or peripheral oedema and assessed NYHA functional class and cardiac function. Abnormal systolic function was defined as EF <40% on Doppler echocardiography. Abnormal diastolic function was defined as reduced E/A ratio and/or an abnormal pattern of pulmonary venous flow. Blood samples were drawn, and BNP and D-dimer were analysed. D-dimer was analysed using an automated micro-latex assay. A statistical analysis was performed to identify the prognostic value of increased plasma concentration of D-dimer. Results showed that during a median follow-up period of 5.5 years, 68 (14%) patients died of cardiovascular disease. No gender difference was noted. A plasma concentration of D-dimer >0.25mg/L increased the risk almost 4-fold. In conclusion, D-dimer is an independent risk factor for cardiovascular mortality that may be used to risk-stratify patients with heart failure.

Preoperative Core Needle Biopsy as an Independent Risk Factor for Wound Infection After Breast Surgery

2003 ◽  
Vol 101 (4) ◽  
pp. 745-750 ◽  
Author(s):  
Armin Witt ◽  
Devrim Yavuz ◽  
Christoph Walchetseder ◽  
Heinz Strohmer ◽  
Ernst Kubista
Keyword(s):  
Risk Factor ◽  
Wound Infection ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Independent Risk Factor ◽  
Breast Surgery ◽  
Core Needle

Impaired renal function is an independent risk factor for complications after surgery for femoral neck fracture

2021 ◽  
pp. 112070002110285
Author(s):  
Pradip Ramamurti ◽  
Safa C Fassihi ◽  
David Sacolick ◽  
Alex Gu ◽  
Chapman Wei ◽  
...  
Keyword(s):  
Renal Function ◽  
Risk Factor ◽  
Femoral Neck ◽  
Femoral Neck Fracture ◽  
Impaired Renal Function ◽  
Independent Risk Factor ◽  
Femoral Neck Fractures ◽  
Stage 4 ◽  
Ckd Stage ◽  
Neck Fracture

Background: The metabolic abnormalities that occur secondary to chronic kidney disease (CKD) increase the risk of femoral neck fractures compared to the general population. The purpose of this study is to determine whether impaired renal function is an independent risk factor for complications after surgery for femoral neck fracture. Methods: The ACS-NSQIP database was reviewed for patients who underwent total hip arthroplasty, hemiarthroplasty and open reduction internal fixation (ORIF) for femoral neck fractures between 2007 and 2018. Patients were split into cohorts based on calculated estimated glomerular filtration rate. Demographic information, comorbidities, and 30-day complications were analysed with univariate and multivariate analyses using chi-square, Fischer’s exact and analysis of variance testing. Results: The total number of patients for the study was 163,717. Patients with CKD stage 4 and 5 had an increased rate of any complication (39.1 and 36.7% respectively) compared with higher eGFRs ( p  < 0.001). Similarly, 30-day mortality was increased at 6.0% and 6.7% for both stage 4 and 5 ( p  < 0.001). By multivariate regression, those with CKD Stage 4 and 5 were at increased risk for any complication compared to patients with a normal preoperative eGFR of 90–120 ( p  < 0.001). Conclusions: This study demonstrated that patients with CKD Stage 4 and 5 are at increased risks of all complications, including death, renal, pulmonary and thromboembolic disease. Therefore, these patients should be cared for from a multidisciplinary approach with close attention to postoperative medications and fall prevention to help mitigate the risk of complications in the immediate postoperative period.

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