Changes in antiepileptic drug prescriptions over a decade in childbearing women in Lombardy region, Italy

Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children’s Hospital in Korea, 2001–2012

Pediatric Drugs ◽

10.1007/s40272-015-0147-z ◽

2015 ◽

Vol 17 (6) ◽

pp. 487-496 ◽

Cited By ~ 8

Author(s):

Yoon Sook Cho ◽

Young-Mi Ah ◽

Ae Hee Jung ◽

Ki Joong Kim ◽

Ju-Yeun Lee

Keyword(s):

Antiepileptic Drug ◽

Drug Prescriptions ◽

Childhood Epilepsy ◽

Children's Hospital ◽

Children’S Hospital

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DRUG PRESCRIPTION PROFILE AND PERINATAL DETERMINANTS DURING THE FIRST YEAR OF LIFE

Archives of Disease in Childhood ◽

10.1136/archdischild-2015-310148.39 ◽

2015 ◽

Vol 101 (1) ◽

pp. e1.33-e1

Author(s):

Daniele Piovani ◽

Antonio Clavenna ◽

Chiara Pavoni ◽

Maurizio Bonati

Keyword(s):

Anatomical Therapeutic Chemical ◽

Drug Prescription ◽

Drug Prescriptions ◽

First Year ◽

Chi Square ◽

Lombardy Region ◽

Drug Classes ◽

Chi Square Test ◽

Socio Demographic Factors ◽

First Year Of Life

The aim of the study was to investigate the drug prescription profile during the first year of life in a cohort of newborns, and the influence of perinatal and socio-demographic factors on drug prescription.A total of 61,479 neonates born in 2011 were included. The data source was the database of reimbursed prescriptions of the Lombardy region, Italy. Drug prescriptions were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. Drug prevalence was calculated as the percentage of neonates receiving at least one drug prescription in one year. Chi-square test was used to compare prevalence of drug prescription in males and females.In all, 42,204 infants (68.7%) received at least one drug prescription, with a prevalence slightly higher in males than females (71.1% versus 66.1%; χ2=178 p<0.01). The drug classes most commonly prescribed in the first year of life were antibiotics (39.5% of infants), anti-asthmatics (32.6%), and corticosteroids for systemic use (9.8%).The median age of first prescription was 20.6 (Interquartile range: 9.4–33.3) weeks. Males received the first prescription about one week before females (20.1 versus 21.3, respectively). The first prescription concerned mainly anti-asthmatics (40.5%), and antibiotics (37.9%), and amoxicillin (16.3%), beclomethasone (16.0%), and amoxicillin+clavulanic acid (15.0%) were the most prescribed drugs.In conclusion, in the first year of life, 7 out of 10 infants received drug prescriptions. Males were more exposed than females, a finding consistent with the epidemiology of diseases in infancy. The analysis concerning the influence of maternal and perinatal factors is ongoing.

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Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: A large population-based study

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2011.05.004 ◽

2011 ◽

Vol 93 (1) ◽

pp. 123-130 ◽

Cited By ~ 29

Author(s):

Marta Baviera ◽

Lara Monesi ◽

Irene Marzona ◽

Fausto Avanzini ◽

Gabriella Monesi ◽

...

Keyword(s):

Large Population ◽

Population Based ◽

Drug Prescriptions ◽

Diabetic Patients ◽

Population Based Study ◽

Lombardy Region

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Association between sociodemographic status and antiepileptic drug prescriptions in children with epilepsy

Epilepsia ◽

10.1111/j.1528-1167.2012.03717.x ◽

2012 ◽

Vol 53 (12) ◽

pp. 2149-2155 ◽

Cited By ~ 12

Author(s):

Peter Mattsson ◽

Torbjörn Tomson ◽

Karin Edebol Eeg-Olofsson ◽

Lars Brännström ◽

Gunilla Ringbäck Weitoft

Keyword(s):

Antiepileptic Drug ◽

Drug Prescriptions

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Sociodemographic differences in antiepileptic drug prescriptions to adult epilepsy patients

Neurology ◽

10.1212/wnl.0b013e3181cbcd5c ◽

2010 ◽

Vol 74 (4) ◽

pp. 295-301 ◽

Cited By ~ 25

Author(s):

P. Mattsson ◽

T. Tomson ◽

O Eriksson ◽

L. Brannstrom ◽

G. R. Weitoft

Keyword(s):

Antiepileptic Drug ◽

Drug Prescriptions ◽

Sociodemographic Differences

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Changes in antiepileptic drug prescriptions over a decade in childbearing women in Lombardy Region, Italy

10.22541/au.162533132.28364440/v1 ◽

2021 ◽

Author(s):

Antonio Clavenna ◽

Rita Campi ◽

Daria Putignano ◽

Ida Fortino ◽

Maurizio Bonati

Keyword(s):

Valproic Acid ◽

Pregnant Women ◽

Antiepileptic Drug ◽

Unplanned Pregnancy ◽

Anatomical Therapeutic Chemical ◽

Educational Interventions ◽

International Classification Of Diseases ◽

Women Of Childbearing Age ◽

Childbearing Age ◽

Lombardy Region

Aim To describe the antiepileptic drug (AED) prescription pattern in pregnant women and women of childbearing age in the 2010-2019 period in the Lombardy region, Italy. Methods The Lombardy region administrative healthcare databases (2010-2019) were analysed. AEDs were classified as drugs belonging to the N03A subgroup of the Anatomical Therapeutic Chemical Classification System. Women 15-49 years old were considered as women of childbearing age, while exposure during pregnancy was estimated taking into account the 12 months before delivery (International Classification of Diseases, Ninth Revision, Clinical Modification, ICD-9-CM codes in the diagnosis record from 650 to 659). Results During 2019, 16,605 women of childbearing age (prevalence: 14.8‰) received at least one AED prescription. Pregabalin was the most widely used antiepileptic in women of childbearing age (22.3%), followed by valproic acid (20.0%). The prevalence of AED prescription in pregnant women was 3.8‰, and levetiracetam and lamotrigine (16.6%) were the most commonly prescribed drugs. The prevalence of AED prescription did not change from 2010 to 2019 in women of childbearing age or in pregnant women. Valproic acid was one of the most used AEDs in pregnancy until 2016, after which its prescription declined from 19% to 14% of AED users. Conclusions Despite the decrease in valproic acid prescription over time, this drug is still among the most used AEDs, in particular in women of childbearing age. Educational interventions for healthcare professionals and women are needed in order to reduce the risk of unplanned pregnancy.

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Acetaminophen: Neonatal hepatotoxicity due to late pregnancy exposure

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100127906 ◽

1987 ◽

Vol 45 ◽

pp. 718-719

Author(s):

G.A. Miranda ◽

M.A. Arroyo ◽

C.A. Lucio ◽

M. Mongeotti ◽

S.S. Poolsawat

Keyword(s):

Low Dose ◽

Fetal Liver ◽

Late Pregnancy ◽

Toxic Chemicals ◽

Control Group ◽

High Dose ◽

Over The Counter ◽

Liver And Kidney ◽

Neonatal Liver ◽

Childbearing Women

Exposure to drugs and toxic chemicals, during late pregnancy, is a common occurrence in childbearing women. Some studies have reported that more than 90% of pregnant women use at least 1 prescription; of this, 60% used more than one. Another study indicated that 80% of the consumed drugs were not prescribed, and of this figure, 95% were “over-the-counter” drugs. Acetaminophen, the safest of all over-the-counter drugs, has been reported to induce fetal liver necrosis in man and animals and to have abortifacient and embryocidal action in mice. This study examines the degree to which acetaminophen affects the neonatal liver and kidney, when a fatty diet is simultaneously fed to the mother during late pregnancy.Timed Swiss Webster female mice were gavaged during late pregnancy (days 16-19) with fat suspended acetaminophen at a high dose, HD = 84.50 mg/kg, and a low dose, LD = 42.25 mg/kg; a control group received fat alone.

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