scholarly journals Effect of renal function on the risk of thrombocytopenia in patients receiving linezolid therapy: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Changcheng Shi ◽  
Junbo Xia ◽  
Jian Ye ◽  
Yaping Xie ◽  
Weizhong Jin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Meta Analysis ◽  
Linezolid Therapy

scholarly journals Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030596 ◽  
Author(s):  
Kathryn S Taylor ◽  
Julie Mclellan ◽  
Jan Y Verbakel ◽  
Jeffrey K Aronson ◽  
Daniel S Lasserson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Glycaemic Control ◽  
Citation Index ◽  
Antihypertensive Drugs ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Low Grade ◽  
All Cause Mortality

ObjectiveTo evaluate the effects of drug interventions that may modify the progression of chronic kidney disease (CKD) in adults with CKD stages 3 and 4.DesignSystematic review and meta-analysis.MethodsSearching MEDLINE, EMBASE, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, International Clinical Trials Registry Platform, Health Technology Assessment, Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index and Clinical Trials Register, from March 1999 to July 2018, we identified randomised controlled trials (RCTs) of drugs for hypertension, lipid modification, glycaemic control and sodium bicarbonate, compared with placebo, no drug or a drug from another class, in ≥40 adults with CKD stages 3 and/or 4, with at least 2 years of follow-up and reporting renal function (primary outcome), proteinuria, adverse events, maintenance dialysis, transplantation, cardiovascular events, cardiovascular mortality or all-cause mortality. Two reviewers independently screened citations and extracted data. For continuous outcomes, we used the ratio of means (ROM) at the end of the trial in random-effects meta-analyses. We assessed methodological quality with the Cochrane Risk of Bias Tool and confidence in the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.ResultsWe included 35 RCTs and over 51 000 patients. Data were limited, and heterogeneity varied. Final renal function (estimated glomerular filtration rate) was 6% higher in those taking glycaemic control drugs (ROM 1.06, 95% CI 1.02 to 1.10, I2=0%, low GRADE confidence) and 4% higher in those taking lipid-modifying drugs (ROM 1.04, 95% CI 1.00 to 1.08, I2=88%, very low GRADE confidence). For RCTs of antihypertensive drugs, there were no significant differences in renal function. Treatment with lipid-modifying drugs led to a 36% reduction in cardiovascular disease and 26% reduction in all-cause mortality.ConclusionsGlycaemic control and lipid-modifying drugs may slow the progression of CKD, but we found no pooled evidence of benefit nor harm from antihypertensive drugs. However, given the data limitations, further research is needed to confirm these findings.PROSPERO registration numberCRD42015017501.

scholarly journals Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0163907 ◽  
Author(s):  
Kun Li ◽  
Jianan Zou ◽  
Zhibin Ye ◽  
Jianzhong Di ◽  
Xiaodong Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bariatric Surgery ◽  
Renal Function ◽  
Meta Analysis ◽  
Obese Patients

scholarly journals SP309DECLINE OF RENAL FUNCTION PRIOR TO DIALYSIS INITIATION IN CKD PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii211-iii211
Author(s):  
Cynthia Janmaat ◽  
Merel van Diepen ◽  
Cheyenne van Hagen ◽  
Joris Rotmans ◽  
Friedo Dekker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Meta Analysis ◽  
Dialysis Initiation
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