scholarly journals Population pharmacokinetics and probability of target attainment in patients with sepsis under renal replacement therapy receiving continuous infusion of meropenem: sustained low‐efficiency dialysis (SLED) and continuous veno‐venous haemodialysis (CVVHD)

2021 ◽  
Author(s):  
Isabella Westermann ◽  
Silke Gastine ◽  
Carsten Müller ◽  
Wiebke Rudolph ◽  
Frank Peters ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Infusion ◽  
Replacement Therapy ◽  
Population Pharmacokinetics ◽  
Target Attainment ◽  
Low Efficiency

THE ROLE OF SLOW LOW EFFICIENCY DIALYSIS (SLED) IN RENAL REPLACEMENT THERAPY

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Małgorzata Kościelska ◽  
Paweł Żebrowski ◽  
Jolanta Małyszko
Keyword(s):  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Low Efficiency

Indications for Dialysis in Acute Kidney Injury

2020 ◽  
Author(s):  
Ankit Patel ◽  
Kenneth B Christopher
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
High Efficiency ◽  
Kidney Injury ◽  
Intermittent Hemodialysis ◽  
Continuous Venovenous Hemofiltration ◽  
Continuous Venovenous Hemodialysis ◽  
Low Efficiency ◽  
The Impact

Renal replacement therapy (RRT) can be used to support patient’s kidney function in cases of acute kidney injury (AKI). However, timing, modality, and dosing of RRT continue to remain in question. Recent studies have begun to provide data to help guide clinicians on when to initiate RRT, what form of RRT to use ranging from continuous venovenous hemofiltration (VVH) to intermittent hemodialysis, and the impact of high versus low-intensity dosing. Additionally, the risks associated with temporary vascular access with regard to thrombosis and infection, the impact of high efficiency and flux versus low efficiency and flux membranes, and options for anticoagulation in RRT for AKI are also discussed. This review contains 75 references.  Key words: acute kidney injury, chronic kidney disease, continuous venovenous hemofiltration, continuous venovenous hemodialysis, renal replacement therapy, venovenous hemofiltration, 

Pharmacokinetics of ceftolozane/tazobactam continuous infusion on renal replacement therapy: a pediatric case report

Therapies ◽  
2021 ◽  
Author(s):  
Charlotte Collignon ◽  
Ines Gana ◽  
Sihem Benaboud ◽  
Julie Toubiana ◽  
Martin Castelle ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Replacement Therapy ◽  
Continuous Infusion ◽  
Replacement Therapy ◽  
Pediatric Case

scholarly journals Population pharmacokinetics of daptomycin in adult patients undergoing continuous renal replacement therapy

2016 ◽  
Vol 83 (3) ◽  
pp. 498-509 ◽  
Author(s):  
Xiaoying Xu ◽  
Dmytro Khadzhynov ◽  
Harm Peters ◽  
Ricardo L. Chaves ◽  
Kamal Hamed ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Continuous Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Population Pharmacokinetics ◽  
Adult Patients

scholarly journals Haemodynamically Unstable Acute Kidney Injury Patients Treated with Sustained Low Efficiency Dialysis: Outcome in an ICU of Bangladesh

2017 ◽  
Vol 42 (1) ◽  
pp. 14-20
Author(s):  
Kaniz Fatema ◽  
Mohammad Omar Faruq
Keyword(s):  
Acute Kidney Injury ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
De Novo ◽  
Tertiary Care ◽  
Kidney Injury ◽  
Cost Effective ◽  
Apache Ii Score ◽  
Care Hospital ◽  
Low Efficiency

Acute kidney injury (AKI) is a risk factor for increased mortality in critically ill patients. Sustained low efficiency dialysis (SLED) is a new approach in renal replacement therapy (RRT) and it combines the advantages of continuous renal replacement therapy (CRRT) and intermittent haemodialysis (HD). The study was aimed to evaluate the outcome of the hae-modynamically unstable patients with AKI in Bangladesh who were treated with SLED. So far this is the first reported study on SLED in intensive care unit (ICU) in Bangladesh. This quasi-experimental study was conducted in a 10-bed adult ICU of a tertiary care hospital in Bangladesh from June 2012 to May 2013. A total of 153 sessions of SLED were performed on 43 AKI patients. Mean age of the patients was 60.12 ± 15.57 years with male preponder-ance (67.4% were male). Mean APACHE II score was 26.88 ± 6.25. Fourteen patients (32.55%) had de novo AKI. Twenty nine patients (67.4%) had chronic kidney disease (CKD) with baseline mean serum creatinine 2.56 mg/dl, but did not require any RRT before admis-sion in ICU. After giving SLED, AKI of the study patients were completely resolved in 27.9%. Some forty two percent patients became dialysis dependant and 30.23% patients died. Patients who had AKI on CKD became dialysis dependant more often than the patients with de novo AKI (p <0.01). Mortality rate was significantly higher in patients who were on inotrope support (p= 0.017). Otherwise, there was no relation of 28 day mortality with age, prior renal function and mechanical ventilator requirement (p>0.05). Thus, SLED is an excellent renal replacement therapy for the haemodynamically unstable AKI patients of ICU. It is also cost-effective compared to CRRT.

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