scholarly journals A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single‐dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers

2020 ◽  
Author(s):  
Adele Hosseini ◽  
Andrew J. McLachlan ◽  
Jason D. Lickliter
Keyword(s):  
Single Dose ◽  
Phase I ◽  
Healthy Volunteers ◽  
Phase I Trial ◽  
Single And Multiple Doses ◽  
Multiple Doses

scholarly journals Safety, Tolerability, and Pharmacokinetic Properties of Intravenous Delafloxacin After Single and Multiple Doses in Healthy Volunteers

2016 ◽  
Vol 38 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Randall Hoover ◽  
Thomas Hunt ◽  
Michael Benedict ◽  
Susan K. Paulson ◽  
Laura Lawrence ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Single And Multiple Doses ◽  
Multiple Doses ◽  
Pharmacokinetic Properties

Metabolism of Sr58 and Ca45 in man after single and multiple doses

1963 ◽  
Vol 18 (4) ◽  
pp. 824-828
Author(s):  
Joseph Samachson
Keyword(s):  
Single Dose ◽  
Predictive Value ◽  
Plasma Levels ◽  
Calcium Metabolism ◽  
Urinary Calcium ◽  
Single And Multiple Doses ◽  
Multiple Doses ◽  
Small Doses

Three patients received single doses of Sr85 and one Ca45 as well, the plasma levels, and urinary and fecal excretions being followed for 3–4 weeks. Calculations were then made to predict plasma levels and excretions following the administration of 12 small doses to each patient, and values predicted were compared with those found. Changes in calcium metabolism limited the predictive value of single-dose data, but when variations in urinary calcium could be allowed for, predicted and found values agreed well. The factors involved in extrapolation from single to multiple doses are discussed. Within certain limitations, the extrapolation appears valid and may be applicable to the problems involved in the investigation of Sr90 as well, although the fact that the latter is ingested over long periods of time makes comparison with single-dose data more hazardous. Submitted on December 21, 1962

Effects of Multiple Doses of Ambrisentan on the Pharmacokinetics of a Single Dose of Digoxin in Healthy Volunteers

2011 ◽  
Vol 51 (1) ◽  
pp. 102-106 ◽  
Author(s):  
Duncan B. Richards ◽  
Rebecca Spence ◽  
Arun Mandagere ◽  
Linda S. Henderson ◽  
Mindy H. Magee
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Multiple Doses
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