scholarly journals Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late‐onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes

2018 ◽  
Vol 85 (1) ◽  
pp. 147-159 ◽  
Author(s):  
Sam Salman ◽  
Julie Hibbert ◽  
Madhu Page‐Sharp ◽  
Laurens Manning ◽  
Karen Simmer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Population Pharmacokinetics ◽  
Clinical Outcomes ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Late Onset ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

scholarly journals Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study

2021 ◽  
Author(s):  
Mathilde Letouzey ◽  
◽  
Laurence Foix-L’Hélias ◽  
Héloïse Torchin ◽  
Ayoub Mitha ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Preterm Infants ◽  
Late Onset ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

scholarly journals Whole blood transcriptional responses of very preterm infants during late-onset sepsis

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0233841 ◽  
Author(s):  
Sherrianne Ng ◽  
Tobias Strunk ◽  
Amy H. Lee ◽  
Erin E. Gill ◽  
Reza Falsafi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Whole Blood ◽  
Late Onset ◽  
Transcriptional Responses ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

scholarly journals Availability of Donor Milk for Very Preterm Infants Decreased the Risk of Necrotizing Enterocolitis without Adversely Impacting Growth or Rates of Breastfeeding

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1895 ◽  
Author(s):  
Débora Cañizo Vázquez ◽  
Sandra Salas García ◽  
Montserrat Izquierdo Renau ◽  
Isabel Iglesias-Platas
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Neonatal Intensive Care ◽  
Late Onset ◽  
Donor Milk ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Breastfeeding Rates ◽  
Group 2 ◽  
Group 1

Human milk contains non-nutritional factors that promote intestinal maturation and protect against infectious and inflammatory conditions. In the Neonatal Intensive Care Unit (NICU) setting, donor milk (DM) is recommended when availability of own mother’s milk (OMM) is not enough. Our aim was to compare the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in very preterm infants (VPI) after the introduction of DM. Growth and breastfeeding rates were examined as secondary outcomes. Single center, observational and retrospective cohort study comparing 227 VPI admitted to our neonatal unit before (Group 1, n = 99) and after (Group 2, n = 128) DM introduction. Enteral nutrition was started earlier after DM availability (2.6 ± 1.1 vs. 2.1 ± 1 days, p = 0.001). Incidence of NEC decreased in group 2 (9.1% vs. 3.4%, p = 0.055), especially in those born between 28 and 32 weeks (5.4 vs. 0.0%, p = 0.044). Surgical NEC was also less frequent. Suffering NEC was 4 times more likely in group 1 (multivariate analysis). Availability of DM did not impact breastfeeding rates or preterm growth. Our findings support the protective role of DM against NEC, particularly in non-extreme VPI, a group less frequently included in clinical guidelines and research studies on the use of DM.

Lactoferrin Expression Is Not Associated with Late-Onset Sepsis in Very Preterm Infants

Neonatology ◽  
2020 ◽  
pp. 1-6
Author(s):  
Tobias Strunk ◽  
Julie Elizabeth Hibbert ◽  
Dorota Doherty ◽  
Elizabeth Nathan ◽  
Karen Simmer ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Late Onset ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial

PEDIATRICS ◽  
2013 ◽  
Vol 132 (6) ◽  
pp. 1055-1062 ◽  
Author(s):  
S. E. Jacobs ◽  
J. M. Tobin ◽  
G. F. Opie ◽  
S. Donath ◽  
S. N. Tabrizi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Late Onset ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomized Controlled ◽  
Late Onset Sepsis

scholarly journals 172 The Proprems Randomised Trial Investigating the Effects of Probiotics on Late Onset Sepsis in Very Preterm Infants

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A50-A50
Author(s):  
S. Jacobs ◽  
J. Tobin ◽  
G. Opie ◽  
S. Donath ◽  
M. Pirotta ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Late Onset ◽  
Randomised Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis

scholarly journals Plasma cytokine profiles in very preterm infants with late-onset sepsis

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0232933
Author(s):  
Julie Hibbert ◽  
Tobias Strunk ◽  
Karen Simmer ◽  
Peter Richmond ◽  
David Burgner ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Late Onset ◽  
Plasma Cytokine ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cytokine Profiles ◽  
Late Onset Sepsis

scholarly journals The ProPrems trial: investigating the effects of probiotics on late onset sepsis in very preterm infants

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Suzanne M Garland ◽  
◽  
Jacinta M Tobin ◽  
Marie Pirotta ◽  
Sepehr N Tabrizi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Late Onset ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Late Onset Sepsis
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